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Protein
Submitted name:

Transcriptional regulator (NtrC family)

Gene

ntrC4

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331ADP; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei352 – 3521ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi163 – 1675ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, DNA-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-126-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (NtrC family)Imported
Gene namesi
Name:ntrC4Imported
Ordered Locus Names:aq_164Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi328 ↔ 362Combined sources

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_164.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZITNMR-A1-121[»]
2JRLNMR-A/B1-121[»]
3DZDX-ray2.40A/B2-369[»]
3E7LX-ray2.25A/B/C/D380-442[»]
4FTHX-ray3.00A/B374-442[»]
ProteinModelPortaliO66551.
SMRiO66551. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 117115Response regulatoryInterPro annotationAdd
BLAST
Domaini132 – 360229Sigma-54 factor interactionInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains sigma-54 factor interaction domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
InParanoidiO66551.
KOiK02481.
OMAiFEAQCLH.
OrthoDBiPOG091H03UM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRVLVVDDE ESITSSLSAI LEEEGYHPDT AKTLREAEKK IKELFFPVIV
60 70 80 90 100
LDVWMPDGDG VNFIDFIKEN SPDSVVIVIT GHGSVDTAVK AIKKGAYEFL
110 120 130 140 150
EKPFSVERFL LTIKHAFEEY SKKAPPQEEI EFVGEHPKIL EIKRLIPKIA
160 170 180 190 200
KSKAPVLITG ESGTGKEIVA RLIHRYSGRK GAFVDLNCAS IPQELAESEL
210 220 230 240 250
FGHEKGAFTG ALTRKKGKLE LADQGTLFLD EVGELDQRVQ AKLLRVLETG
260 270 280 290 300
SFTRLGGNQK IEVDIRVISA TNKNLEEEIK KGNFREDLYY RLSVFQIYLP
310 320 330 340 350
PLRERGKDVI LLAEYFLKKF AKEYKKNCFE LSEETKEYLM KQEWKGNVRE
360 370 380 390 400
LKNLIERAVI LCEGEVIKPE DLGLKEKSWR DLSYLLKIKE LKEAKKEFEK
410 420 430 440
IFIEEKLREY DYDLKRTAEE IGIDLSNLYR KIKSLNIRVK SS
Length:442
Mass (Da):50,742
Last modified:August 1, 1998 - v1
Checksum:iF04A1A4091979B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06509.1.
PIRiD70315.
RefSeqiNP_213111.1. NC_000918.1.
WP_010880049.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06509; AAC06509; aq_164.
GeneIDi1192694.
KEGGiaae:aq_164.
PATRICi20958000. VBIAquAeo85532_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06509.1.
PIRiD70315.
RefSeqiNP_213111.1. NC_000918.1.
WP_010880049.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZITNMR-A1-121[»]
2JRLNMR-A/B1-121[»]
3DZDX-ray2.40A/B2-369[»]
3E7LX-ray2.25A/B/C/D380-442[»]
4FTHX-ray3.00A/B374-442[»]
ProteinModelPortaliO66551.
SMRiO66551. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06509; AAC06509; aq_164.
GeneIDi1192694.
KEGGiaae:aq_164.
PATRICi20958000. VBIAquAeo85532_0140.

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
InParanoidiO66551.
KOiK02481.
OMAiFEAQCLH.
OrthoDBiPOG091H03UM.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-126-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO66551.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO66551_AQUAE
AccessioniPrimary (citable) accession number: O66551
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.