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Protein
Submitted name:

AP4A hydrolase

Gene

apfA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei6 – 61ATPCombined sources
Binding sitei31 – 311ATPCombined sources
Binding sitei67 – 671ATPCombined sources
Binding sitei78 – 781ATPCombined sources
Binding sitei115 – 1151ATPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Ligandi

ATP-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-123-MONOMER.
BRENDAi3.6.1.17. 396.

Names & Taxonomyi

Protein namesi
Submitted name:
AP4A hydrolaseImported
Gene namesi
Name:apfAImported
Ordered Locus Names:aq_158Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_158.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7UX-ray1.80A/B/C/D1-134[»]
3I7VX-ray1.95A/B1-134[»]
ProteinModelPortaliO66548.
SMRiO66548. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66548.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 127126Nudix hydrolaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.UniRule annotation
Contains nudix hydrolase domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108WNV. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000261976.
InParanoidiO66548.
KOiK03574.
OMAiYEGWVLP.
OrthoDBiEOG6SR962.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEFSAGGV LFKDGEVLLI KTPSNVWSFP KGNIEPGEKP EETAVREVWE
60 70 80 90 100
ETGVKGEILD YIGEIHYWYT LKGERIFKTV KYYLMKYKEG EPRPSWEVKD
110 120 130
AKFFPIKEAK KLLKYKGDKE IFEKALKLKE KFKL
Length:134
Mass (Da):15,756
Last modified:August 1, 1998 - v1
Checksum:iDA363A35A82628DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06510.1.
PIRiA70315.
RefSeqiNP_213108.1. NC_000918.1.
WP_010880046.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06510; AAC06510; aq_158.
GeneIDi1192691.
KEGGiaae:aq_158.
PATRICi20957992. VBIAquAeo85532_0136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06510.1.
PIRiA70315.
RefSeqiNP_213108.1. NC_000918.1.
WP_010880046.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7UX-ray1.80A/B/C/D1-134[»]
3I7VX-ray1.95A/B1-134[»]
ProteinModelPortaliO66548.
SMRiO66548. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06510; AAC06510; aq_158.
GeneIDi1192691.
KEGGiaae:aq_158.
PATRICi20957992. VBIAquAeo85532_0136.

Phylogenomic databases

eggNOGiENOG4108WNV. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000261976.
InParanoidiO66548.
KOiK03574.
OMAiYEGWVLP.
OrthoDBiEOG6SR962.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-123-MONOMER.
BRENDAi3.6.1.17. 396.

Miscellaneous databases

EvolutionaryTraceiO66548.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH ATP.

Entry informationi

Entry nameiO66548_AQUAE
AccessioniPrimary (citable) accession number: O66548
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.