O66540 (DEOC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	aq_148

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Deoxyribose-phosphate aldolase HAMAP MF_00114

PRO_0000057220

Sites

Active site

150

1

Schiff-base intermediate with acetaldehyde By similarity

Active site

179

1

By similarity

Secondary structure

1

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219

Helix Strand Turn

Details...

Helix

4 – 7

4

Beta strand

8 – 12

5

Helix

19 – 31

13

Beta strand

35 – 39

5

Helix

41 – 43

3

Helix

44 – 50

7

Beta strand

52 – 61

10

Turn

62 – 64

3

Helix

69 – 81

13

Beta strand

85 – 90

6

Helix

93 – 97

5

Helix

101 – 113

13

Beta strand

118 – 123

6

Helix

126 – 128

3

Helix

131 – 144

14

Beta strand

147 – 150

4

Beta strand

156 – 158

3

Helix

162 – 172

11

Beta strand

175 – 183

9

Helix

187 – 195

9

Beta strand

199 – 204

6

Sequences

	Sequence		Length	Mass (Da)
	O66540 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 7CFC455A136AB827	FASTA	219	24,182
	10 20 30 40 50 60 MIDVRKYIDN AALKPHLSEK EIEEFVLKSE ELGIYAVCVN PYHVKLASSI AKKVKVCCVI 70 80 90 100 110 120 GFPLGLNKTS VKVKEAVEAV RDGAQELDIV WNLSAFKSEK YDFVVEELKE IFRETPSAVH 130 140 150 160 170 180 KVIVETPYLN EEEIKKAVEI CIEAGADFIK TSTGFAPRGT TLEEVRLIKS SAKGRIKVKA 190 200 210 SGGIRDLETA ISMIEAGADR IGTSSGISIA EEFLKRHLI

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000657 Genomic DNA. Translation: AAC06495.1.

PIR

A70314.

RefSeq

NP_213100.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MZH	X-ray	2.00	A/B	1-219	[»]

ProteinModelPortal

O66540.

SMR

O66540. Positions 1-219.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1192683.

GenomeReviews

Gene locus aq_148 in contig AE000657_GR.

KEGG

aae:aq_148.

NMPDR

fig|224324.1.peg.115.

PATRIC

20957968. VBIAquAeo85532_0124.

Phylogenomic databases

HOGENOM

HBG636421.

OMA

IDHTNLK.

PhylomeDB

O66540.

ProtClustDB

PRK00507.

Enzyme and pathway databases

BioCyc

AAEO224324:AQ_148-MONOMER.

Family and domain databases

HAMAP

MF_00114. DeoC_type1.
[Tree]

InterPro

IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/AroFGH_arch.
IPR022979. Deoxyribose_phosphate_aldo_1.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.

KO

K01619.

PANTHER

PTHR10889. DeoC. 1 hit.

Pfam

PF01791. DeoC. 1 hit.
[Graphical view]

PIRSF

PIRSF001357. DeoC. 1 hit.

TIGRFAMs

TIGR00126. DeoC. 1 hit.

ProtoNet

Search...

Entry information

Entry name

DEOC_AQUAE

Accession

Primary (citable) accession number: O66540

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program