O66520 (TAL_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable transaldolase
EC=2.2.1.2

Gene names

Name:	tal
Synonyms:	talC
Ordered Locus Names:	aq_119

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity. HAMAP MF_00494
Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. HAMAP MF_00494
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. HAMAP MF_00494
Subcellular location	Cytoplasm By similarity HAMAP MF_00494.
Sequence similarities	Belongs to the transaldolase family. Type 3B subfamily.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Probable transaldolase HAMAP MF_00494		PRO_0000173652
Sites
	Active site	83	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O66520 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 457D5305C68EDD6B	FASTA	217	23,978
	10 20 30 40 50 60 MKFFLDTANV EEIKKAMEWG ILDGVTTNPT LISKTGRPFK EVVKEILELV DGPVSLETVS 70 80 90 100 110 120 LDAEGMIREG RMLAELGENV VVKIPMTPEG LKAVIALESE GIPTNVTLVF SPTQALLAAK 130 140 150 160 170 180 AGASYVSPFV GRLDDISGEG MKLIEEIKTI FSNYEFDTEI IVASVRHPMH VLESALIGAD 190 200 210 ICTMPFKVME QLFKHPLTDI GLERFLKDWE KVPEKPF

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06476.1.
PIR	E70311.
RefSeq	NP_213080.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O66520.
SMR	O66520. Positions 1-214.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1192531.
GenomeReviews	Gene locus aq_119 in contig AE000657_GR.
KEGG	aae:aq_119.
NMPDR	fig|224324.1.peg.95.
PATRIC	20957926. VBIAquAeo85532_0103.
Phylogenomic databases
HOGENOM	HBG533000.
OMA	KVNVTLC.
PhylomeDB	O66520.
ProtClustDB	PRK01362.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_119-MONOMER.
Family and domain databases
HAMAP	MF_00494. Transaldolase_3b. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001585. Transaldolase. IPR004731. Transaldolase_3A/3B. IPR022999. Transaldolase_3B. IPR018225. Transaldolase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00616.
PANTHER	PTHR10683. Transaldolase. 1 hit.
Pfam	PF00923. Transaldolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00875. Fsa_talC_mipB. 1 hit.
PROSITE	PS01054. TRANSALDOLASE_1. 1 hit. PS00958. TRANSALDOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TAL_AQUAE

Accession

Primary (citable) accession number: O66520

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program