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O66519

- PGK_AQUAE

UniProt

O66519 - PGK_AQUAE

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei203 – 2031ATPBy similarity
Binding sitei294 – 2941ATP; via carbonyl oxygenBy similarity
Binding sitei325 – 3251ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi351 – 3544ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-94-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:aq_118
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Phosphoglycerate kinasePRO_0000145898Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_118.

Structurei

3D structure databases

ProteinModelPortaliO66519.
SMRiO66519. Positions 3-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 243Substrate bindingBy similarity
Regioni61 – 644Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
InParanoidiO66519.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66519-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRKKTLRDV DVKGKRVLVR VDYNVPLDEQ GNIVDDTRIR ASLPTVEYLL
60 70 80 90 100
DANAKVILMS HLGRPKNRDP KYSLAPVAKR LSRYINKEVK LAPDCVGEEV
110 120 130 140 150
KRIVNSMKEG DVVLLENLRF HKEETECDEN FARELASLGE VYVADAFGTC
160 170 180 190 200
HRKHASVYLV PKFLKPAVMG FLLEKEITYF EKAMVAPQRP VVAILGGAKV
210 220 230 240 250
SSKLEVIKNL IRRVDKLFIG GAMAFTFLKA MGYKVGNSLV EDDLQDVARD
260 270 280 290 300
LIDVAKKLEI KLYLPVDFVI GQEVSENTPT KVVPWQEIPD GWMGLDIGPV
310 320 330 340 350
SVELVKEIIS DAQTIVWNGP MGVFEIDKFK HGTIEVAKLL AQSSALTIAG
360 370 380 390
GGDTDHAIHK AGVYHAFDFV STGGGAFLEL LAGKELPCLV NLDDKEA
Length:397
Mass (Da):43,956
Last modified:August 1, 1998 - v1
Checksum:iBF66BA208A8EBC57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06475.1.
PIRiD70311.
RefSeqiNP_213079.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06475; AAC06475; aq_118.
GeneIDi1192530.
KEGGiaae:aq_118.
PATRICi20957924. VBIAquAeo85532_0102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06475.1 .
PIRi D70311.
RefSeqi NP_213079.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66519.
SMRi O66519. Positions 3-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06475 ; AAC06475 ; aq_118 .
GeneIDi 1192530.
KEGGi aae:aq_118.
PATRICi 20957924. VBIAquAeo85532_0102.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
InParanoidi O66519.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci AAEO224324:GJBH-94-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiPGK_AQUAE
AccessioniPrimary (citable) accession number: O66519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3