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O66514

- GLNA_AQUAE

UniProt

O66514 - GLNA_AQUAE

Protein

Glutamine synthetase

Gene

glnA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-89-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:aq_111
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Glutamine synthetasePRO_0000153228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei398 – 3981O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Protein-protein interaction databases

    STRINGi224324.aq_111.

    Structurei

    3D structure databases

    ProteinModelPortaliO66514.
    SMRiO66514. Positions 5-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005157.
    KOiK01915.
    OMAiSCRIPYV.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR004809. Gln_synth_I.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O66514-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKYTPEEVL DLIQKEGVQY VDLRFSDPFG QWQHLTIPAY EISKETFEVG    50
    RGFDGSSIRG WQSINESDML AKPDPNTAFI DPFIEPKTLV MICDIYDPVT 100
    GERYGRDTRY IAQKAEQYLK QTGIGDTAYF GPEAEFFIFD SVEFGTAANY 150
    AFWRVDSEEG WWNREVPSSG YKIPHKRGYF PAPPVDKMMQ LRNEMVSIMS 200
    DLGIIVELHH HEVATAGQGE IDIRYDSLLN QADKLFLYKY IVRMVAAKHG 250
    KYATFMAKVL PNDNGSGMHT HFSIWKNGEN LFAGSEYAGL SKTALYAIGG 300
    ILKHGPAIAA FTNPTVNSYH RLVPGYEAPV RLAYSARNRS AAIRIPMYSQ 350
    NPKAKRIEVR FPDATSNPYL AFAAILMAAI DGIENEIDPG EPFDKDIYSL 400
    PPEELEGIPQ LPGSLEEALK ALEEDYEFLL KGNVFTEEFI QLWIESKRAE 450
    IDELRFIPHP KEFELYWDI 469
    Length:469
    Mass (Da):53,294
    Last modified:August 1, 1998 - v1
    Checksum:i688504C9FD95B056
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06472.1.
    PIRiG70310.
    RefSeqiNP_213074.1. NC_000918.1.
    WP_010880012.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06472; AAC06472; aq_111.
    GeneIDi1192525.
    KEGGiaae:aq_111.
    PATRICi20957910. VBIAquAeo85532_0095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06472.1 .
    PIRi G70310.
    RefSeqi NP_213074.1. NC_000918.1.
    WP_010880012.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66514.
    SMRi O66514. Positions 5-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06472 ; AAC06472 ; aq_111 .
    GeneIDi 1192525.
    KEGGi aae:aq_111.
    PATRICi 20957910. VBIAquAeo85532_0095.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005157.
    KOi K01915.
    OMAi SCRIPYV.
    OrthoDBi EOG6B360N.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-89-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR004809. Gln_synth_I.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiGLNA_AQUAE
    AccessioniPrimary (citable) accession number: O66514
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3