Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O66514

- GLNA_AQUAE

UniProt

O66514 - GLNA_AQUAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamine synthetase

Gene

glnA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-89-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:aq_111
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetasePRO_0000153228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi224324.aq_111.

Structurei

3D structure databases

ProteinModelPortaliO66514.
SMRiO66514. Positions 5-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
InParanoidiO66514.
KOiK01915.
OMAiSCRIPYV.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.

Sequencei

Sequence statusi: Complete.

O66514-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKYTPEEVL DLIQKEGVQY VDLRFSDPFG QWQHLTIPAY EISKETFEVG
60 70 80 90 100
RGFDGSSIRG WQSINESDML AKPDPNTAFI DPFIEPKTLV MICDIYDPVT
110 120 130 140 150
GERYGRDTRY IAQKAEQYLK QTGIGDTAYF GPEAEFFIFD SVEFGTAANY
160 170 180 190 200
AFWRVDSEEG WWNREVPSSG YKIPHKRGYF PAPPVDKMMQ LRNEMVSIMS
210 220 230 240 250
DLGIIVELHH HEVATAGQGE IDIRYDSLLN QADKLFLYKY IVRMVAAKHG
260 270 280 290 300
KYATFMAKVL PNDNGSGMHT HFSIWKNGEN LFAGSEYAGL SKTALYAIGG
310 320 330 340 350
ILKHGPAIAA FTNPTVNSYH RLVPGYEAPV RLAYSARNRS AAIRIPMYSQ
360 370 380 390 400
NPKAKRIEVR FPDATSNPYL AFAAILMAAI DGIENEIDPG EPFDKDIYSL
410 420 430 440 450
PPEELEGIPQ LPGSLEEALK ALEEDYEFLL KGNVFTEEFI QLWIESKRAE
460
IDELRFIPHP KEFELYWDI
Length:469
Mass (Da):53,294
Last modified:August 1, 1998 - v1
Checksum:i688504C9FD95B056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06472.1.
PIRiG70310.
RefSeqiNP_213074.1. NC_000918.1.
WP_010880012.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06472; AAC06472; aq_111.
GeneIDi1192525.
KEGGiaae:aq_111.
PATRICi20957910. VBIAquAeo85532_0095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06472.1 .
PIRi G70310.
RefSeqi NP_213074.1. NC_000918.1.
WP_010880012.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66514.
SMRi O66514. Positions 5-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06472 ; AAC06472 ; aq_111 .
GeneIDi 1192525.
KEGGi aae:aq_111.
PATRICi 20957910. VBIAquAeo85532_0095.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
InParanoidi O66514.
KOi K01915.
OMAi SCRIPYV.
OrthoDBi EOG6B360N.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-89-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR004809. Gln_synth_I.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiGLNA_AQUAE
AccessioniPrimary (citable) accession number: O66514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3