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Protein

Glutamine synthetase

Gene

glnA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-89-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:aq_111
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetasePRO_0000153228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi224324.aq_111.

Structurei

3D structure databases

ProteinModelPortaliO66514.
SMRiO66514. Positions 5-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
InParanoidiO66514.
KOiK01915.
OMAiLMVDFKF.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.

Sequencei

Sequence statusi: Complete.

O66514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKYTPEEVL DLIQKEGVQY VDLRFSDPFG QWQHLTIPAY EISKETFEVG
60 70 80 90 100
RGFDGSSIRG WQSINESDML AKPDPNTAFI DPFIEPKTLV MICDIYDPVT
110 120 130 140 150
GERYGRDTRY IAQKAEQYLK QTGIGDTAYF GPEAEFFIFD SVEFGTAANY
160 170 180 190 200
AFWRVDSEEG WWNREVPSSG YKIPHKRGYF PAPPVDKMMQ LRNEMVSIMS
210 220 230 240 250
DLGIIVELHH HEVATAGQGE IDIRYDSLLN QADKLFLYKY IVRMVAAKHG
260 270 280 290 300
KYATFMAKVL PNDNGSGMHT HFSIWKNGEN LFAGSEYAGL SKTALYAIGG
310 320 330 340 350
ILKHGPAIAA FTNPTVNSYH RLVPGYEAPV RLAYSARNRS AAIRIPMYSQ
360 370 380 390 400
NPKAKRIEVR FPDATSNPYL AFAAILMAAI DGIENEIDPG EPFDKDIYSL
410 420 430 440 450
PPEELEGIPQ LPGSLEEALK ALEEDYEFLL KGNVFTEEFI QLWIESKRAE
460
IDELRFIPHP KEFELYWDI
Length:469
Mass (Da):53,294
Last modified:August 1, 1998 - v1
Checksum:i688504C9FD95B056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06472.1.
PIRiG70310.
RefSeqiNP_213074.1. NC_000918.1.
WP_010880012.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06472; AAC06472; aq_111.
GeneIDi1192525.
KEGGiaae:aq_111.
PATRICi20957910. VBIAquAeo85532_0095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06472.1.
PIRiG70310.
RefSeqiNP_213074.1. NC_000918.1.
WP_010880012.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66514.
SMRiO66514. Positions 5-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06472; AAC06472; aq_111.
GeneIDi1192525.
KEGGiaae:aq_111.
PATRICi20957910. VBIAquAeo85532_0095.

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
InParanoidiO66514.
KOiK01915.
OMAiLMVDFKF.
OrthoDBiEOG6B360N.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-89-MONOMER.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiGLNA_AQUAE
AccessioniPrimary (citable) accession number: O66514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.