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Protein

2-dehydro-3-deoxyphosphooctonate aldolase

Gene

kdsA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate.

Pathwayi: 3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
  3. no protein annotated in this organism
This subpathway is part of the pathway 3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate, the pathway 3-deoxy-D-manno-octulosonate biosynthesis and in Carbohydrate biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-71-MONOMER.
BRENDAi2.5.1.55. 396.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase (EC:2.5.1.55)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name:
KDO 8-P synthase
Short name:
KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene namesi
Name:kdsA
Ordered Locus Names:aq_085
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2672672-dehydro-3-deoxyphosphooctonate aldolasePRO_0000187099Add
BLAST

Interactioni

Subunit structurei

Oligomer.

Protein-protein interaction databases

STRINGi224324.aq_085.

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Helixi16 – 3217Combined sources
Beta strandi36 – 416Combined sources
Helixi60 – 7415Combined sources
Beta strandi77 – 815Combined sources
Helixi85 – 873Combined sources
Helixi88 – 925Combined sources
Beta strandi96 – 1005Combined sources
Helixi102 – 1043Combined sources
Helixi108 – 1158Combined sources
Turni116 – 1183Combined sources
Beta strandi119 – 1246Combined sources
Helixi131 – 1344Combined sources
Helixi135 – 1439Combined sources
Beta strandi147 – 1537Combined sources
Beta strandi159 – 1613Combined sources
Helixi169 – 1735Combined sources
Turni174 – 1763Combined sources
Beta strandi177 – 1826Combined sources
Helixi185 – 1873Combined sources
Turni190 – 1934Combined sources
Beta strandi194 – 1963Combined sources
Helixi201 – 2033Combined sources
Helixi204 – 21411Combined sources
Beta strandi217 – 2259Combined sources
Helixi227 – 2293Combined sources
Beta strandi231 – 2333Combined sources
Turni234 – 2363Combined sources
Beta strandi237 – 2393Combined sources
Helixi240 – 2423Combined sources
Helixi243 – 25816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FWNX-ray1.94A/B1-267[»]
1FWSX-ray1.90A/B1-267[»]
1FWTX-ray1.90A/B1-267[»]
1FWWX-ray1.85A/B1-267[»]
1FX6X-ray2.06A/B1-267[»]
1FXPX-ray1.80A/B1-267[»]
1FXQX-ray1.80A/B1-267[»]
1FY6X-ray1.89A/B1-267[»]
1JCXX-ray1.80A/B1-267[»]
1JCYX-ray1.90A/B1-267[»]
1LRNX-ray2.10A/B1-267[»]
1LROX-ray1.80A/B1-267[»]
1LRQX-ray1.80A/B1-267[»]
1PCKX-ray1.80A/B1-267[»]
1PCWX-ray1.85A/B1-267[»]
1PE1X-ray1.74A/B1-267[»]
1T8XX-ray1.80A/B1-267[»]
1T96X-ray1.85A/B1-267[»]
1T99X-ray1.85A/B1-267[»]
1ZHAX-ray1.74A/B1-267[»]
1ZJIX-ray2.25A/B1-267[»]
2A21X-ray1.80A/B1-267[»]
2A2IX-ray1.95A/B1-267[»]
2EF9X-ray2.00A/B1-267[»]
2NWRX-ray1.50A/B1-267[»]
2NWSX-ray1.80A/B1-267[»]
2NX1X-ray1.80A/B1-267[»]
2NX3X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L1-267[»]
2NXGX-ray1.95A/B2-264[»]
2NXHX-ray2.11A/B/C/D/E/F/G/H/I/J/K/L2-264[»]
2NXIX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L2-264[»]
3E0IX-ray1.70A/B1-267[»]
3E12X-ray1.70A/B1-267[»]
ProteinModelPortaliO66496.
SMRiO66496. Positions 2-264.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66496.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.Curated

Phylogenomic databases

eggNOGiENOG4105CXR. Bacteria.
COG2877. LUCA.
HOGENOMiHOG000023021.
InParanoidiO66496.
KOiK01627.
OMAiFRGIPTM.
OrthoDBiPOG091H00ND.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

O66496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFLVIAGP CAIESEELLL KVGEEIKRLS EKFKEVEFVF KSSFDKANRS
60 70 80 90 100
SIHSFRGHGL EYGVKALRKV KEEFGLKITT DIHESWQAEP VAEVADIIQI
110 120 130 140 150
PAFLCRQTDL LLAAAKTGRA VNVKKGQFLA PWDTKNVVEK LKFGGAKEIY
160 170 180 190 200
LTERGTTFGY NNLVVDFRSL PIMKQWAKVI YDATHSVQLP GGLGDKSGGM
210 220 230 240 250
REFIFPLIRA AVAVGCDGVF METHPEPEKA LSDASTQLPL SQLEGIIEAI
260
LEIREVASKY YETIPVK
Length:267
Mass (Da):29,734
Last modified:August 1, 1998 - v1
Checksum:i0A3CFEA3337F1964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06457.1.
PIRiE70308.
RefSeqiNP_213056.1. NC_000918.1.
WP_010879994.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06457; AAC06457; aq_085.
GeneIDi1192509.
KEGGiaae:aq_085.
PATRICi20957869. VBIAquAeo85532_0075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06457.1.
PIRiE70308.
RefSeqiNP_213056.1. NC_000918.1.
WP_010879994.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FWNX-ray1.94A/B1-267[»]
1FWSX-ray1.90A/B1-267[»]
1FWTX-ray1.90A/B1-267[»]
1FWWX-ray1.85A/B1-267[»]
1FX6X-ray2.06A/B1-267[»]
1FXPX-ray1.80A/B1-267[»]
1FXQX-ray1.80A/B1-267[»]
1FY6X-ray1.89A/B1-267[»]
1JCXX-ray1.80A/B1-267[»]
1JCYX-ray1.90A/B1-267[»]
1LRNX-ray2.10A/B1-267[»]
1LROX-ray1.80A/B1-267[»]
1LRQX-ray1.80A/B1-267[»]
1PCKX-ray1.80A/B1-267[»]
1PCWX-ray1.85A/B1-267[»]
1PE1X-ray1.74A/B1-267[»]
1T8XX-ray1.80A/B1-267[»]
1T96X-ray1.85A/B1-267[»]
1T99X-ray1.85A/B1-267[»]
1ZHAX-ray1.74A/B1-267[»]
1ZJIX-ray2.25A/B1-267[»]
2A21X-ray1.80A/B1-267[»]
2A2IX-ray1.95A/B1-267[»]
2EF9X-ray2.00A/B1-267[»]
2NWRX-ray1.50A/B1-267[»]
2NWSX-ray1.80A/B1-267[»]
2NX1X-ray1.80A/B1-267[»]
2NX3X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L1-267[»]
2NXGX-ray1.95A/B2-264[»]
2NXHX-ray2.11A/B/C/D/E/F/G/H/I/J/K/L2-264[»]
2NXIX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L2-264[»]
3E0IX-ray1.70A/B1-267[»]
3E12X-ray1.70A/B1-267[»]
ProteinModelPortaliO66496.
SMRiO66496. Positions 2-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06457; AAC06457; aq_085.
GeneIDi1192509.
KEGGiaae:aq_085.
PATRICi20957869. VBIAquAeo85532_0075.

Phylogenomic databases

eggNOGiENOG4105CXR. Bacteria.
COG2877. LUCA.
HOGENOMiHOG000023021.
InParanoidiO66496.
KOiK01627.
OMAiFRGIPTM.
OrthoDBiPOG091H00ND.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00474.
BioCyciAAEO224324:GJBH-71-MONOMER.
BRENDAi2.5.1.55. 396.

Miscellaneous databases

EvolutionaryTraceiO66496.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDSA_AQUAE
AccessioniPrimary (citable) accession number: O66496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.