Skip Header

Contribute Send feedback
Read comments (?) or add your own

O66493 (AROC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:aq_081
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex ›

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP-Rule MF_00300

Cofactor

Reduced flavin By similarity.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP-Rule MF_00300

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the chorismate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Chorismate synthase HAMAP-Rule MF_00300
PRO_0000140537

Secondary structure

1 ........................................................ 398
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O66493 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: A0C59327BFA3B39A

FASTA39844,254
        10         20         30         40         50         60 
MSLRYLRFLT AGESHGKGLT AILEGIPANL PLSEEEINHE LRRRQRGYGR GGRMKIEKDT 

        70         80         90        100        110        120 
AEILSGVRFG KTLGSPIALF IRNRDWENWK EKMAIEGEPS PSVVPFTRPR PGHADLSGGI 

       130        140        150        160        170        180 
KYNQRDLRNI LERASARETA ARVAVGAVCK KFLSEFGIKI GSFVVSIGQK EVEELKDKSY 

       190        200        210        220        230        240 
FANPEKLLSY HEKAEDSELR IPFPEKDEEF KTYIDEVKEK GESLGGVFEV FALNVPPGLG 

       250        260        270        280        290        300 
SHIQWDRRID GRIAQAMMSI QAIKGVEIGL GFEAARRFGS QVHDEIGWSE GKGYFRHSNN 

       310        320        330        340        350        360 
LGGTEGGITN GMPIVVRVAM KPIPTLKNPL RSVDIETKEE MKAGKERTDI VAVPAASVVG 

       370        380        390 
EAMLAIVLAD ALLEKLGGDF MEEVKKRFED YVNHVKSF

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06434.1.
PIRB70308.
RefSeqNP_213053.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1LX-ray2.05A/B/C/D1-398[»]
ProteinModelPortalO66493.
SMRO66493. Positions 2-398.
ModBaseSearch...

Protein-protein interaction databases

STRING224324.aq_081.

Proteomic databases

PRIDEO66493.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06434; AAC06434; aq_081.
GeneID1192506.
KEGGaae:aq_081.
PATRIC20957861. VBIAquAeo85532_0071.

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHOG000060334.
KOK01736.
OMASQVHDEI.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-68-MONOMER.
UniPathwayUPA00053; UER00090.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
PANTHERPTHR21085. PTHR21085. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. aroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO66493.

Entry information

Entry nameAROC_AQUAE
AccessionPrimary (citable) accession number: O66493
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents