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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:aq_079
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicAdd BLAST13
Transmembranei14 – 40Helical; Name=1Add BLAST27
Topological domaini41 – 64PeriplasmicAdd BLAST24
Transmembranei65 – 98Discontinuously helical; Name=Helix 2Add BLAST34
Intramembranei65 – 72Helical; Name=Helix 2A8
Intramembranei73 – 775
Intramembranei78 – 98Helical; Name=Helix 2BAdd BLAST21
Topological domaini99 – 111CytoplasmicAdd BLAST13
Transmembranei112 – 132Helical; Name=3Add BLAST21
Topological domaini133 – 154PeriplasmicAdd BLAST22
Transmembranei155 – 178Helical; Name=4Add BLAST24
Topological domaini179 – 181Cytoplasmic3
Transmembranei182 – 200Helical; Name=5Add BLAST19
Topological domaini201 – 214PeriplasmicAdd BLAST14
Transmembranei215 – 235Helical; Name=6Add BLAST21
Topological domaini236 – 267CytoplasmicAdd BLAST32
Transmembranei268 – 286Helical; Name=7Add BLAST19
Topological domaini287 – 307PeriplasmicAdd BLAST21
Transmembranei308 – 329Helical; Name=8Add BLAST22
Topological domaini330 – 360CytoplasmicAdd BLAST31
Transmembranei361 – 385Helical; Name=9Add BLAST25
Topological domaini386 – 393Periplasmic8
Transmembranei394 – 414Helical; Name=10Add BLAST21
Topological domaini415 – 429CytoplasmicAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317071 – 429Protein translocase subunit SecYAdd BLAST429

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-59810N.
STRINGi224324.aq_079.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DL8X-ray7.50G/H1-429[»]
ProteinModelPortaliO66491.
SMRiO66491.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66491.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
InParanoidiO66491.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYLKALFE LKELRQKFIF TLLMFVIYRL GSHIPIPGIN PEALRDFLKA
60 70 80 90 100
FEGSVFALYD IFSGGNLGRL TVFALGVMPY ISASIMMQLL TVAIPSLQRL
110 120 130 140 150
AKEEGDYGRY KINEYTKYLT LFVATVQSLG IAFWIRGQVS PKGIPVVENP
160 170 180 190 200
GISFILITVL TLVAGTMFLV WIADRITEKG IGNGASLIIF AGIVANFPNA
210 220 230 240 250
VIQFYEKVKT GDIGPLTLLL IIALIIAIIV GIVYVQEAER RIPIQYPGRQ
260 270 280 290 300
VGRQLYAGRK TYLPIKINPA GVIPIIFAQA LLLIPSTLLN FVQNPFIKVI
310 320 330 340 350
ADMFQPGAIF YNFLYVTFIV FFTYFYTAVL INPVELAENL HKAGAFIPGV
360 370 380 390 400
RPGQDTVKYL ERIINRLIFF GALFLSVIAL IPILISVWFN IPFYFGGTTA
410 420
LIVVGVALDT FRQIETYLIQ KKYKSYVRR
Length:429
Mass (Da):48,100
Last modified:August 1, 1998 - v1
Checksum:i87D4FC133D037C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06435.1.
PIRiH70307.
RefSeqiNP_213051.1. NC_000918.1.
WP_010879989.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06435; AAC06435; aq_079.
GeneIDi1192504.
KEGGiaae:aq_079.
PATRICi20957857. VBIAquAeo85532_0069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06435.1.
PIRiH70307.
RefSeqiNP_213051.1. NC_000918.1.
WP_010879989.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DL8X-ray7.50G/H1-429[»]
ProteinModelPortaliO66491.
SMRiO66491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59810N.
STRINGi224324.aq_079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06435; AAC06435; aq_079.
GeneIDi1192504.
KEGGiaae:aq_079.
PATRICi20957857. VBIAquAeo85532_0069.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
InParanoidiO66491.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Miscellaneous databases

EvolutionaryTraceiO66491.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_AQUAE
AccessioniPrimary (citable) accession number: O66491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.