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Reviewed, UniProtKB/Swiss-Prot O66465 (MRAY_AQUAE)

Last modified February 9, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name: mraY
Ordered Locus Names: aq_053
OrganismAquifex aeolicus [Complete proteome] [HAMAP]
Taxonomic identifier63363 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108772

Regions

Transmembrane26 – 4621 Potential
Transmembrane73 – 9321 Potential
Transmembrane100 – 12021 Potential
Transmembrane143 – 16321 Potential
Transmembrane166 – 18621 Potential
Transmembrane197 – 21721 Potential
Transmembrane234 – 25421 Potential
Transmembrane261 – 28121 Potential
Transmembrane287 – 30721 Potential
Transmembrane336 – 35621 Potential

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Sequences

Sequence LengthMass (Da)Tools
O66465-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: B2D6292EA6EA16D4

FASTA35940,341
        10         20         30         40         50         60 
MLYQLALLLK DYWFAFNVLK YITFRSFTAV LIAFFLTLVL SPSFINRLRK IQRLFGGYVR 

        70         80         90        100        110        120 
EYTPESHEVK KYTPTMGGIV ILIVVTLSTL LLMRWDIKYT WVVLLSFLSF GTIGFWDDYV 

       130        140        150        160        170        180 
KLKNKKGISI KTKFLLQVLS ASLISVLIYY WADIDTILYF PFFKELYVDL GVLYLPFAVF 

       190        200        210        220        230        240 
VIVGSANAVN LTDGLDGLAI GPAMTTATAL GVVAYAVGHS KIAQYLNIPY VPYAGELTVF 

       250        260        270        280        290        300 
CFALVGAGLG FLWFNSFPAQ MFMGDVGSLS IGASLATVAL LTKSEFIFAV AAGVFVFETI 

       310        320        330        340        350 
SVILQIIYFR WTGGKRLFKR APFHHHLELN GLPEPKIVVR MWIISILLAI IAISMLKLR

« Hide

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References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06418.1.
PIRF70304.
RefSeqNP_213025.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1192662.
GenomeReviewsGene locus aq_053 in contig AE000657_GR.
KEGGaae:aq_053.
NMPDRfig|224324.1.peg.40.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMAHHHFEQK.
PhylomeDBO66465.

Enzyme and pathway databases

BioCycAAEO224324:AQ_053-MONOMER.
BRENDA2.7.8.13. 189781.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR018481. Glycosyl_Trfase_4_cons-reg.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMRAY_AQUAE
AccessionPrimary (citable) accession number: O66465
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 9, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents