Reviewed,
UniProtKB/Swiss-Prot O66465 (MRAY_AQUAE)
Last modified
November 3, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospho-N-acetylmuramoyl-pentapeptide-transferase EC=2.7.8.13 Alternative name(s): UDP-MurNAc-pentapeptide phosphotransferase | ||||
| Gene names |
| ||||
| Organism | Aquifex aeolicus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 63363 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. |
| Catalytic activity | UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038 |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 4 family. MraY subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038 | PRO_0000108772 | |||||
Regions | |||||||||
| Transmembrane | 26 – 46 | 21 | Potential | ||||||
| Transmembrane | 73 – 93 | 21 | Potential | ||||||
| Transmembrane | 100 – 120 | 21 | Potential | ||||||
| Transmembrane | 143 – 163 | 21 | Potential | ||||||
| Transmembrane | 166 – 186 | 21 | Potential | ||||||
| Transmembrane | 197 – 217 | 21 | Potential | ||||||
| Transmembrane | 234 – 254 | 21 | Potential | ||||||
| Transmembrane | 261 – 281 | 21 | Potential | ||||||
| Transmembrane | 287 – 307 | 21 | Potential | ||||||
| Transmembrane | 336 – 356 | 21 | Potential | ||||||
Sequences
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References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
Cross-references
Sequence databases | |
|---|---|
| AE000657 Genomic DNA. Translation: AAC06418.1. | |
| PIR | F70304. |
| RefSeq | NP_213025.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1192662. |
| GenomeReviews | Gene locus aq_053 in contig AE000657_GR. |
| KEGG | aae:aq_053. |
| NMPDR | fig|224324.1.peg.40. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O66465. |
| OMA | HHHFEQK. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_053-MON. |
| BRENDA | 2.7.8.13. 189781. |
Family and domain databases | |
| HAMAP | MF_00038. [Tree] |
| InterPro | IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view] |
| PANTHER | PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit. |
| Pfam | PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00445. mraY. 1 hit. |
| PROSITE | PS01347. MRAY_1. 1 hit. PS01348. MRAY_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MRAY_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O66465 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


