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O66440 (AROD_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:aq_021
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214

Subunit structure

Homodimer By similarity. HAMAP MF_00214

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2192193-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000138792

Sites

Active site1161Proton acceptor By similarity
Active site1421Schiff-base intermediate with substrate By similarity

Secondary structure

1 ....................................... 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O66440 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 144C4D5240C86F46

FASTA21924,971
        10         20         30         40         50         60 
MLIAVPLDDT NFSENLKKAK EKGADIVELR VDQFSDTSLN YVKEKLEEVH SQGLKTILTI 

        70         80         90        100        110        120 
RSPEEGGREV KNREELFEEL SPLSDYTDIE LSSRGLLVKL YNITKEAGKK LIISYHNFEL 

       130        140        150        160        170        180 
TPPNWIIREV LREGYRYGGI PKIAVKANSY EDVARLLCIS RQVEGEKILI SMGDYGKISR 

       190        200        210 
LAGYVFGSVI TYCSLEKAFA PGQIPLEEMV ELRKKFYRL

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06389.1.
PIRE70301.
RefSeqNP_212999.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGZX-ray1.75A/C1-219[»]
2YSWX-ray2.25A/B/C1-219[»]
ProteinModelPortalO66440.
SMRO66440. Positions 1-219.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1192637.
GenomeReviewsGene locus aq_021 in contig AE000657_GR.
KEGGaae:aq_021.
NMPDRfig|224324.1.peg.14.
PATRIC20957747. VBIAquAeo85532_0014.

Phylogenomic databases

HOGENOMHBG732926.
OMAVARRTVI.
PhylomeDBO66440.
ProtClustDBCLSK2748236.

Enzyme and pathway databases

BioCycAAEO224324:AQ_021-MONOMER.

Family and domain databases

HAMAPMF_00214. AroD.
[Tree]
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK03785.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. AroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_AQUAE
AccessionPrimary (citable) accession number: O66440
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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