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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi333 – 352H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Alternative name(s):
Sigma-43
Sigma-A
Gene namesi
Name:sigAUniRule annotation
Synonyms:rpoD
Ordered Locus Names:BH1376
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938731 – 372RNA polymerase sigma factor SigAAdd BLAST372

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH1376

Structurei

3D structure databases

ProteinModelPortaliO66381
SMRiO66381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 209Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni218 – 294Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni307 – 360Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 166Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoD/SigA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
KOiK03086
OMAiYQRWLAE
OrthoDBiPOG091H0012

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR007127 RNA_pol_sigma_70_r1_1
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF03979 Sigma70_r1_1, 1 hit
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

O66381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPLRPLA EGELSIDQVK EQLVELGKKR GVLTYAEITE KLAPYDQDSD
60 70 80 90 100
QMDEFFEYLG EQGVEILNDN EEVPSLQQVE KEEEEFDLND LSVPPGVKIN
110 120 130 140 150
DPVRMYLKEI GRVPLLTAEE EIELATRIEQ GDEEAKRRLA EANLRLVVSI
160 170 180 190 200
AKRYVGRGML FLDLIQEGNM GLIKAVEKFD YNKGFKFSTY ATWWIRQAIT
210 220 230 240 250
RAIADQARTI RIPVHMVETI NKLIRVQRQL LQDLGREPSP EEVAEEMDLT
260 270 280 290 300
PEKVREILKI AQEPVSLETP IGEEDDSHLG DFIEDQDALA PSDAAAYELL
310 320 330 340 350
KEQLEDVLDT LTDREENVLR LRFGLDDGRT RTLEEVGKVF GVTRERIRQI
360 370
EAKALRKLRH PSRSKRLKDF LE
Length:372
Mass (Da):42,741
Last modified:December 1, 2000 - v2
Checksum:iFFB1555BC155FE12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234L → V in BAA25730 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012852 Genomic DNA Translation: BAA25730.1
BA000004 Genomic DNA Translation: BAB05095.1
PIRiH83821
RefSeqiWP_010897541.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB05095; BAB05095; BAB05095
KEGGibha:BH1376

Similar proteinsi

Entry informationi

Entry nameiSIGA_BACHD
AccessioniPrimary (citable) accession number: O66381
Secondary accession number(s): Q9KD43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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