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Protein

60 kDa chaperonin

Gene

groL

Organism
Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Taxonomic identifieri549 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaePantoeaPantoea agglomerans group

Subcellular locationi

O66200:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633681 – ›53960 kDa chaperoninAdd BLAST›539

Proteomic databases

PRIDEiO66200.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO66200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Fragment.

O66200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN DARVKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAII
110 120 130 140 150
TEGLKAVAAG MNPMDLKRGI DKAVASAVEE LKALSVPCSD SKAIAQVGTI
160 170 180 190 200
SANSDETVGK LIAEAMDKVG KEGVITVEDG TGLEDELDVV EGMQFDRGYL
210 220 230 240 250
SPYFINKPET GAVELESPFI LLADKKISNI REMLPVLEAV AKAGKPLVII
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIATLTGGTV
310 320 330 340 350
ISEEIGMELE KATLEDLGQA KRVVINKDTT TIIDGVGEEA AIQGRVGQIR
360 370 380 390 400
KQIEEATSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVDDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALV RVAAKLAGLT AQNEDQNVGI KVALRAMEAP
460 470 480 490 500
LRQIVSNAGE EPSVVANNVK AGEGNYGYNA ATEEYGNMID FGILDPTKVT
510 520 530
RSALQYAASV AGLMITTECM VTDMPKGDAP DLXAAGMGG
Length:539
Mass (Da):56,375
Last modified:August 1, 1998 - v1
Checksum:i6583295F73299C3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei5391

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti98A → S in strain: JCM 7000. 1
Natural varianti122K → Q in strain: JCM 7000. 1
Natural varianti125 – 126AS → IA in strain: JCM 7000. 2
Natural varianti130E → K in strain: JCM 7000. 1
Natural varianti160K → Q in strain: JCM 7000. 1
Natural varianti164E → Q in strain: JCM 7000. 1
Natural varianti167D → E in strain: JCM 7000. 1
Natural varianti179D → E in strain: JCM 7000. 1
Natural varianti184E → Q in strain: JCM 7000. 1
Natural varianti213V → I in strain: JCM 7000. 1
Natural varianti248V → L in strain: JCM 7000. 1
Natural varianti294T → I in strain: JCM 7000. 1
Natural varianti313T → A in strain: JCM 7000. 1
Natural varianti341A → T in strain: JCM 7000. 1
Natural varianti347G → T in strain: JCM 7000. 1
Natural varianti351K → Q in strain: JCM 7000. 1
Natural varianti362R → K in strain: JCM 7000. 1
Natural varianti379I → L in strain: JCM 7000. 1
Natural varianti397D → E in strain: JCM 7000. 1
Natural varianti425 – 431KLAGLTA → QLVDLRG in strain: JCM 7000. 7
Natural varianti449A → S in strain: JCM 7000. 1
Natural varianti473E → D in strain: JCM 7000. 1
Natural varianti481A → Q in strain: JCM 7000. 1
Natural varianti524M → L in strain: JCM 7000. 1
Natural varianti534 – 535AA → GGAG in strain: JCM 7000. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008142 Genomic DNA. Translation: BAA25217.1.
AB008150 Genomic DNA. Translation: BAA25233.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_ENTAG
AccessioniPrimary (citable) accession number: O66200
Secondary accession number(s): O66216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families