ID   ISPA_MICLU              Reviewed;         291 AA.
AC   O66126;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Geranyltranstransferase;
DE            EC=2.5.1.10;
DE   AltName: Full=Farnesyl-diphosphate synthase;
DE            Short=FPP synthase;
GN   Name=fps;
OS   Micrococcus luteus (Micrococcus lysodeikticus).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Micrococcus.
OX   NCBI_TaxID=1270;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B-P 26;
RX   MEDLINE=98175686; PubMed=9515931;
RA   Shimizu N., Koyama T., Ogura K.;
RT   "Molecular cloning, expression, and characterization of the genes
RT   encoding the two essential protein components of Micrococcus luteus B-
RT   P 26 hexaprenyl diphosphate synthase.";
RL   J. Bacteriol. 180:1578-1581(1998).
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + trans,trans-farnesyl diphosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthetase family.
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DR   EMBL; AB003187; BAA25265.1; -; Genomic_DNA.
DR   BRENDA; 2.5.1.10; 873.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR017446; Polyprenyl_synth-rel.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   PANTHER; PTHR12001; Polyprenyl_synt; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHET_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHET_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isoprene biosynthesis; Transferase.
FT   CHAIN         1    291       Geranyltranstransferase.
FT                                /FTId=PRO_0000123991.
SQ   SEQUENCE   291 AA;  32362 MW;  797125AB71E5674A CRC64;
     MLQEKLTMNR DFLNLINESL LNKYHPAQSR LHEAINYSLS AGGKRIRPLL VLTTLDSLGG
     NAHDGLPFGI ALEMIHTYSL IHDDLPAMDN DDYRRGKLTN HKRFDEATAI LAGDALLTDA
     FQCILNTQLN AEIKLSLINL LSTASGSNGM VYGQMLDMQG EHKTLTLNEL ERIHIHKTGE
     LIRAAIVSAG IIMNFNDAQI EQLNIIGKNV GLMFQIKDDI LDVEGSFENI GKTVGSDLNN
     DKSTYVSLLG LEASKQLLND KLTETYDALK TLQPINDNLK TLITYIVERN K
//