Reviewed, UniProtKB/Swiss-Prot O66126 (ISPA_MICLU)

Names and origin

Protein names

Recommended name:
    Geranyltranstransferase
    EC=2.5.1.10
Alternative name(s):
    Farnesyl-diphosphate synthase
      Short name=FPP synthase

Gene names

Name:

fps

Organism

Micrococcus luteus (Micrococcus lysodeikticus)

Taxonomic identifier

1270 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Micrococcus

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Geranyltranstransferase		PRO_0000123991

Sequences

	Sequence		Length	Mass (Da)
	O66126-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 797125AB71E5674A	FASTA	291	32,362
	10 20 30 40 50 60 MLQEKLTMNR DFLNLINESL LNKYHPAQSR LHEAINYSLS AGGKRIRPLL VLTTLDSLGG 70 80 90 100 110 120 NAHDGLPFGI ALEMIHTYSL IHDDLPAMDN DDYRRGKLTN HKRFDEATAI LAGDALLTDA 130 140 150 160 170 180 FQCILNTQLN AEIKLSLINL LSTASGSNGM VYGQMLDMQG EHKTLTLNEL ERIHIHKTGE 190 200 210 220 230 240 LIRAAIVSAG IIMNFNDAQI EQLNIIGKNV GLMFQIKDDI LDVEGSFENI GKTVGSDLNN 250 260 270 280 290 DKSTYVSLLG LEASKQLLND KLTETYDALK TLQPINDNLK TLITYIVERN K

References

[1]

"Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase." Shimizu N., Koyama T., Ogura K. J. Bacteriol. 180:1578-1581(1998) [PubMed: 9515931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B-P 26.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB003187 Genomic DNA. Translation: BAA25265.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.10. 873.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ISPA_MICLU

Accession

Primary (citable) accession number: O66126

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)