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O66113

- ODPB_ZYMMO

UniProt

O66113 - ODPB_ZYMMO

Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Binds 1 lipoyl cofactor covalently.
    Binds 1 thiamine pyrophosphate per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei195 – 1951Thiamine pyrophosphateBy similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from pyruvate Source: InterPro
    2. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1993-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
    Gene namesi
    Name:pdhB
    Synonyms:pdhAbeta
    Ordered Locus Names:ZMO1605
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Pyruvate dehydrogenase E1 component subunit betaPRO_0000162237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431N6-lipoyllysineSequence Analysis

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi264203.ZMO1605.

    Structurei

    3D structure databases

    ProteinModelPortaliO66113.
    SMRiO66113. Positions 138-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7777Lipoyl-bindingAdd
    BLAST

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.Curated

    Keywords - Domaini

    Lipoyl

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281450.
    KOiK00162.
    OMAiYASWYAH.
    OrthoDBiEOG6JQH4C.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR000089. Biotin_lipoyl.
    IPR027110. PDHB.
    IPR011053. Single_hybrid_motif.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view]
    PANTHERiPTHR11624:SF56. PTHR11624:SF56. 1 hit.
    PfamiPF00364. Biotin_lipoyl. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O66113-1 [UniParc]FASTAAdd to Basket

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    MAIELKMPAL SPTMEEGTLT RWLVKEGDSI KAGEILAEIE TDKAIMEFEA    50
    VDEGVITKIL IPEGSENVKV GTAIAYLGTD ANDVTLDGAS AETKAEESAP 100
    VASPAKTEAA AVEEAATPSL GKVINSAPEI PEGTEFFQQT LREALRDAMA 150
    EEMRRDDRVF VMGEEVAEYQ GAYKVTQGLL QEFGARRVVD TPISEYGFSG 200
    IGVGAAMEGL RPVIEFMTMN FSMQAIDHII NSAAKTHYMS GGQVRCPIVF 250
    RGPNGAAPRV GAQHTQNFGP WYAAVPGLVV LAPYDAIDAK GLLKAAIRSD 300
    DPVVFLECEL LYGKTFDVPK MDDFVLPIGK ARIIREGKDV TIVSYSIGVS 350
    FALTAAEALA KEGIDAEVID LRTLRPLDKE TILQSLAKTN RIVTVEDGWP 400
    VCSISSEIAA IAMEEGFDNL DAPVLRVTNA DTPTPYAENL EKKGLVNPEA 450
    IIEAVRKVCY RK 462
    Length:462
    Mass (Da):49,833
    Last modified:February 15, 2005 - v2
    Checksum:i00F53CE4A5731F1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871D → E in CAA73385. (PubMed:9515924)Curated
    Sequence conflicti112 – 1121V → L in CAA73385. (PubMed:9515924)Curated
    Sequence conflicti232 – 24413SAAKT…SGGQV → LRPKRIICPAAKC1 PublicationCuratedAdd
    BLAST
    Sequence conflicti259 – 2591R → P in AAC70362. 1 PublicationCurated
    Sequence conflicti262 – 2621A → E in AAC70362. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12884 Genomic DNA. Translation: CAA73385.1.
    AF086791 Genomic DNA. Translation: AAC70362.1.
    AE008692 Genomic DNA. Translation: AAV90229.1.
    PIRiT33723.
    RefSeqiYP_163340.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV90229; AAV90229; ZMO1605.
    GeneIDi3187757.
    KEGGizmo:ZMO1605.
    PATRICi32568468. VBIZymMob102260_1510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12884 Genomic DNA. Translation: CAA73385.1 .
    AF086791 Genomic DNA. Translation: AAC70362.1 .
    AE008692 Genomic DNA. Translation: AAV90229.1 .
    PIRi T33723.
    RefSeqi YP_163340.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali O66113.
    SMRi O66113. Positions 138-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV90229 ; AAV90229 ; ZMO1605 .
    GeneIDi 3187757.
    KEGGi zmo:ZMO1605.
    PATRICi 32568468. VBIZymMob102260_1510.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281450.
    KOi K00162.
    OMAi YASWYAH.
    OrthoDBi EOG6JQH4C.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-1993-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR000089. Biotin_lipoyl.
    IPR027110. PDHB.
    IPR011053. Single_hybrid_motif.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view ]
    PANTHERi PTHR11624:SF56. PTHR11624:SF56. 1 hit.
    Pfami PF00364. Biotin_lipoyl. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification of the pyruvate dehydrogenase multienzyme complex of Zymomonas mobilis and identification and sequence analysis of the corresponding genes."
      Neveling U., Klasen R., Bringer-Meyer S., Sahm H.
      J. Bacteriol. 180:1540-1548(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 29191 / DSM 3580 / NBRC 13756 / NCIMB 11199 / NRRL B-4490 / ZM6.
    2. Lee J., Jin S., Kang H.S.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiODPB_ZYMMO
    AccessioniPrimary (citable) accession number: O66113
    Secondary accession number(s): O69012, Q5NM31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3