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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciZMOB264203:G1FZK-1454-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:pdhAalpha
Ordered Locus Names:ZMO1606
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622131 – 354Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST354

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliO66112
SMRiO66112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000281336
KOiK00161
OMAiYRSHGFT

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

O66112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATQDSNR PHKADVGSAI PNHDLPPIPG RYHADREELL EFYRRMLMIR
60 70 80 90 100
RFEERCGQLY GLGLIAGFCH LYIGQEAVAV GLQAALQPGR DSVITGYREH
110 120 130 140 150
GHMLAYGIDP KIVMAELTGR ASGISHGKGG SMHMFSTEHK FFGGNGIVGA
160 170 180 190 200
QVPLGAGLAF AHKYRNDGGC SAAYFGDGSA NQGQVYEAYN MAALWKLPVI
210 220 230 240 250
FVIENNGYAM GTSIQRANAH TALSERGAGF GIPALVVDGM DVLEVRGAAT
260 270 280 290 300
VAVDWVQAGK GPIILEMKTY RYRGHSMSDP ARYRSREEVN DMKENHDPLD
310 320 330 340 350
NLKKDLFAAG VPEAELVKLD EDIRQQVKEA ADFAEKAPLP ADEELYTNIL

VGKY
Length:354
Mass (Da):38,654
Last modified:August 1, 1998 - v1
Checksum:i515F5B2EDA0C1424
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69C → N in AAC70361 (Ref. 2) Curated1
Sequence conflicti309Missing in AAC70361 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12884 Genomic DNA Translation: CAA73384.1
AF086791 Genomic DNA Translation: AAC70361.1
AE008692 Genomic DNA Translation: AAV90230.1
PIRiT33722
RefSeqiWP_011241360.1, NC_006526.2

Genome annotation databases

EnsemblBacteriaiAAV90230; AAV90230; ZMO1606
KEGGizmo:ZMO1606

Similar proteinsi

Entry informationi

Entry nameiODPA_ZYMMO
AccessioniPrimary (citable) accession number: O66112
Secondary accession number(s): O69011, Q5NM30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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