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O66112

- ODPA_ZYMMO

UniProt

O66112 - ODPA_ZYMMO

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1992-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:pdhAalpha
Ordered Locus Names:ZMO1606
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162213Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi264203.ZMO1606.

Structurei

3D structure databases

ProteinModelPortaliO66112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiEYAMGTS.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

O66112-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKATQDSNR PHKADVGSAI PNHDLPPIPG RYHADREELL EFYRRMLMIR
60 70 80 90 100
RFEERCGQLY GLGLIAGFCH LYIGQEAVAV GLQAALQPGR DSVITGYREH
110 120 130 140 150
GHMLAYGIDP KIVMAELTGR ASGISHGKGG SMHMFSTEHK FFGGNGIVGA
160 170 180 190 200
QVPLGAGLAF AHKYRNDGGC SAAYFGDGSA NQGQVYEAYN MAALWKLPVI
210 220 230 240 250
FVIENNGYAM GTSIQRANAH TALSERGAGF GIPALVVDGM DVLEVRGAAT
260 270 280 290 300
VAVDWVQAGK GPIILEMKTY RYRGHSMSDP ARYRSREEVN DMKENHDPLD
310 320 330 340 350
NLKKDLFAAG VPEAELVKLD EDIRQQVKEA ADFAEKAPLP ADEELYTNIL

VGKY
Length:354
Mass (Da):38,654
Last modified:August 1, 1998 - v1
Checksum:i515F5B2EDA0C1424
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691C → N in AAC70361. 1 PublicationCurated
Sequence conflicti309 – 3091Missing in AAC70361. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12884 Genomic DNA. Translation: CAA73384.1.
AF086791 Genomic DNA. Translation: AAC70361.1.
AE008692 Genomic DNA. Translation: AAV90230.1.
PIRiT33722.
RefSeqiYP_163341.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90230; AAV90230; ZMO1606.
GeneIDi3187783.
KEGGizmo:ZMO1606.
PATRICi32568470. VBIZymMob102260_1511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12884 Genomic DNA. Translation: CAA73384.1 .
AF086791 Genomic DNA. Translation: AAC70361.1 .
AE008692 Genomic DNA. Translation: AAV90230.1 .
PIRi T33722.
RefSeqi YP_163341.1. NC_006526.2.

3D structure databases

ProteinModelPortali O66112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV90230 ; AAV90230 ; ZMO1606 .
GeneIDi 3187783.
KEGGi zmo:ZMO1606.
PATRICi 32568470. VBIZymMob102260_1511.

Phylogenomic databases

eggNOGi COG1071.
HOGENOMi HOG000281336.
KOi K00161.
OMAi EYAMGTS.
OrthoDBi EOG6JMMWC.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1992-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification of the pyruvate dehydrogenase multienzyme complex of Zymomonas mobilis and identification and sequence analysis of the corresponding genes."
    Neveling U., Klasen R., Bringer-Meyer S., Sahm H.
    J. Bacteriol. 180:1540-1548(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29191 / DSM 3580 / NBRC 13756 / NCIMB 11199 / NRRL B-4490 / ZM6.
  2. Lee J., Jin S., Kang H.S.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiODPA_ZYMMO
AccessioniPrimary (citable) accession number: O66112
Secondary accession number(s): O69011, Q5NM30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3