Reviewed,
UniProtKB/Swiss-Prot O66076 (PGSA_TREPA)
Last modified
November 3, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase EC=2.7.8.5 Alternative name(s): Phosphatidylglycerophosphate synthase Short name=PGP synthase | ||||||
| Gene names |
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| Organism | Treponema pallidum [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 160 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity. |
| Catalytic activity | CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. |
| Pathway | |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 216 | 216 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | PRO_0000056792 | |||||
Regions | |||||||||
| Transmembrane | 40 – 60 | 21 | Potential | ||||||
| Transmembrane | 88 – 108 | 21 | Potential | ||||||
| Transmembrane | 141 – 161 | 21 | Potential | ||||||
| Transmembrane | 176 – 196 | 21 | Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Shevchenko D.V., Akins D.R., Robinson E.J., Shevchenko O.V., Radolf J.D. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| U95744 Genomic DNA. Translation: AAC08322.1. AE000520 Genomic DNA. Translation: AAC65245.1. | |
| PIR | E71346. |
| RefSeq | NP_218697.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O66076. 3 interactions. |
Genome annotation databases | |
| GeneID | 2611722. |
| GenomeReviews | Gene locus TP_0256 in contig AE000520_GR. |
| KEGG | tpa:TP0256. |
| NMPDR | fig|243276.1.peg.256. |
| TIGR | TP_0256. |
Phylogenomic databases | |
| OMA | AAATIFI. |
Enzyme and pathway databases | |
| BioCyc | TPAL243276:TP_0256-MON. |
| BRENDA | 2.7.8.5. 142600. |
Family and domain databases | |
| InterPro | IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view] |
| Pfam | PF01066. CDP-OH_P_transf. 1 hit. [Graphical view] |
| PIRSF | PIRSF000847. Phos_ph_gly_syn. 1 hit. |
| TIGRFAMs | TIGR00560. pgsA. 1 hit. |
| PROSITE | PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGSA_TREPA | ||||||||
| Accession | Primary (citable) accession number: O66076 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


