O66076 (PGSA_TREPA) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase EC=2.7.8.5 Alternative name(s): Phosphatidylglycerophosphate synthase Short name=PGP synthase | ||||||
| Gene names |
| ||||||
| Organism | Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 243276 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema › ![]() |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity. |
| Catalytic activity | CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. |
| Pathway | |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | phosphatidylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 216 | 216 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | PRO_0000056792 | |||||
Regions | |||||||||
| Transmembrane | 40 – 60 | 21 | Helical; Potential | ||||||
| Transmembrane | 88 – 108 | 21 | Helical; Potential | ||||||
| Transmembrane | 141 – 161 | 21 | Helical; Potential | ||||||
| Transmembrane | 176 – 196 | 21 | Helical; Potential | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Shevchenko D.V., Akins D.R., Robinson E.J., Shevchenko O.V., Radolf J.D. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U95744 Genomic DNA. Translation: AAC08322.1. AE000520 Genomic DNA. Translation: AAC65245.1. |
| PIR | E71346. |
| RefSeq | NP_218697.1. NC_000919.1. |
3D structure databases | |
| ProteinModelPortal | O66076. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O66076. 3 interactions. |
| STRING | 243276.TP0256. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAC65245; AAC65245; TP_0256. |
| GeneID | 2611722. |
| KEGG | tpa:TP0256. |
| PATRIC | 20530501. VBITrePal57110_0276. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0558. |
| KO | K00995. |
| OMA | NIIMAIA. |
| ProtClustDB | CLSK218612. |
Enzyme and pathway databases | |
| UniPathway | UPA00084; UER00503. |
Family and domain databases | |
| InterPro | IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view] |
| Pfam | PF01066. CDP-OH_P_transf. 1 hit. [Graphical view] |
| PIRSF | PIRSF000847. Phos_ph_gly_syn. 1 hit. |
| TIGRFAMs | TIGR00560. pgsA. 1 hit. |
| PROSITE | PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGSA_TREPA | ||||||||
| Accession | Primary (citable) accession number: O66076 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
