O66076 (PGSA_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA
Synonyms:	pgs
Ordered Locus Names:	TP_0256

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056792
Regions
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O66076 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: DC1B9A66D8A85FE3	FASTA	216	24,639
	10 20 30 40 50 60 MRLSDFYTAL RLALVLPFFA LYHMSRWVVM YFPAANVGRV VSIASVLLFL FIACTDFLDG 70 80 90 100 110 120 YYARKSGKYS SFGKVFDPFA DVIANVTVML CLVADNFMPV FLFLCILYRE FGMMFLRMLA 130 140 150 160 170 180 CGEGHVVGAQ RMGKLKTASY MGAVLFSLLL KALYAFELAG ADWYERMRAV GRLVYVVPVV 190 200 210 LALASFFSYL KTFFPILKRV CGRTRYPVCK TCREWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Shevchenko D.V., Akins D.R., Robinson E.J., Shevchenko O.V., Radolf J.D. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95744 Genomic DNA. Translation: AAC08322.1. AE000520 Genomic DNA. Translation: AAC65245.1.
PIR	E71346.
RefSeq	NP_218697.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O66076.
ModBase	Search...
Protein-protein interaction databases
IntAct	O66076. 3 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2611722.
GenomeReviews	Gene locus TP_0256 in contig AE000520_GR.
KEGG	tpa:TP0256.
NMPDR	fig|243276.1.peg.256.
PATRIC	20530501. VBITrePal57110_0276.
TIGR	TP_0256.
Phylogenomic databases
HOGENOM	HBG686655.
OMA	FSVWSAV.
ProtClustDB	CLSK218612.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0256-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
KO	K00995.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. PgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_TREPA

Accession

Primary (citable) accession number: O66076

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program