O66069 (O66069_BACLI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lichenysin synthetase A EMBL AAD04757.1

Gene names

Name:

licA EMBL AAD04757.1

Organism

Bacillus licheniformis EMBL AAD04757.1

Taxonomic identifier

1402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	3582 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Gene Ontology (GO)
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O66069 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 164E66D1103C1BE1	FASTA	3,582	402,576
	10 20 30 40 50 60 MGNTFYPLTH AQRRIWYTEK FYPGTSVSNL SGFGKLKSAS GIDSGLLTEA IRQFVRTNET 70 80 90 100 110 120 MRFRLMFEGE DEPKQYIAED EPFQIECFDA SESGGADGVL KWGQAEARRP LPLYGSPLFK 130 140 150 160 170 180 FAVVRISEEE SWFFAKVHHI ISDGISMTIL GNRITDIYLK LAKGETGLEP VQSSFTEHIQ 190 200 210 220 230 240 SELEYENSKR FQKDKAYWNA QYEVIPEPVS LKSSDTYQIQ LDAARFSKEI SPALYKKIQT 250 260 270 280 290 300 YCKEHNISVL SLFLSILHIY MHRITGQKDV VLGTFMGNRT NAKEKQMLGM FVLTIPMKAS 310 320 330 340 350 360 IDVHQDFSAF VQERMKDQLK IIRHQKYPYN LLINDLRERQ PHVSKLFSVS LEYQVMQWQR 370 380 390 400 410 420 KETLSFLTEP IFSGSEVNDI SIHVKERWDT GTLAIDFDYR EELFTCEELA VLYERLMTLL 430 440 450 460 470 480 EDALLFPQKT IAELEIVPAF EKERLLKRAS SQTIAYDKNM TLHGLFEQKA ADHPEKTAVV 490 500 510 520 530 540 YEGQKLSYRE LNEQSNRLAR ALRRRGIGPD APAAVVMERS ERVITAMLGV LKAGGAYVPI 550 560 570 580 590 600 DPGFPEERIR FMLEDSKVKV VITDSGLTFE TAETVRFSEA LSESLENGHP SSEAGAGHLA 610 620 630 640 650 660 YIIYTSGTTG RPKGVMIEHR QVHHLVRGLQ QAVGAYDQDD LKLALLAPFH FDASVQQIFT 670 680 690 700 710 720 SLLLGQTLYI VPKKTVSDGR ALSDYYRRHQ IDVTDGTPAH LQLLSAADDL SGVKLRHMLV 730 740 750 760 770 780 GGEALSRVAT ERLLQLFAET AESVPDVTNV YGPTETCVDA SSFTMTNHAD LQGDTAYVPI 790 800 810 820 830 840 GRPIGNNRFY ILDENGALLP DGVEGELYIA GDGVGRGYLN LPDMTADKFL EDPFVPGGFM 850 860 870 880 890 900 YRTGDAVRWL PDGTVDFIGR KDDQVKIRGY RIELGEIESV LQGAPAVGKA VVLARPETGG 910 920 930 940 950 960 SLEVCAYVVP KQSGEIHLQG LREHLSKHLP DYMIPSHFVE LDEIPLTGSG KVDRKALLRH 970 980 990 1000 1010 1020 EVSVSGTAEY AAPRNEYEEK MVGIWQEVLG TEQVGIHDQF FELGGHSLKA MAMLAKIYKA 1030 1040 1050 1060 1070 1080 FGVEVPLQVL FEKPTVAALS GFVSEAEKDG FTVIEPAPES DDYPLSLAQQ RIYIVSQLED 1090 1100 1110 1120 1130 1140 AGVGYNMPAA AMLEGTLDVQ RLEAAFQKLI DRHEALRTSF TVVDGEPRQN IHQRVQFKIE 1150 1160 1170 1180 1190 1200 KVKADGKPIE QMAKSFVRRF DLAKAPLMRA GLVRLADRRH VLLFDMHHLV SDGVSISIIL 1210 1220 1230 1240 1250 1260 NELAALYKGE ELPEPNLHYK DYAFWQRTHA PKGFQKEEAY WQSVFARELP VLQLITDEPR 1270 1280 1290 1300 1310 1320 PSVQSFEGDR VSAVLPQDMK EKLAVLAEQN GATLYMVMLA AYNMLLAKYS GQEDVIVGTP 1330 1340 1350 1360 1370 1380 AAGRRHSDLE GIIGMFVNTL AIRSKVESGR TFRDFLHDVK KTVIDAFEHQ EYPFERLAEK 1390 1400 1410 1420 1430 1440 VGASRDLSRH PVFDTMFILQ NAWEDIPMLG DLHLSIYETN FNIAKFDLTL QAKEEQGELI 1450 1460 1470 1480 1490 1500 LDLDYSTKLF KKDTAERMLK AYLHLLEGMT ADPLRRIGEY SLLTEEETNR QLVAFNPAAS 1510 1520 1530 1540 1550 1560 DYPREKTIVQ LFEEQAAERG GHPALQFEDK VWSYGELNRK ANQLARRLRE RGVQPGTTAA 1570 1580 1590 1600 1610 1620 ILTARSAEMV IGILAVLKAG AAYVPIDPDH PEKRVQHFFE DSGAAVLLTQ KAMKPLAEAA 1630 1640 1650 1660 1670 1680 EFGGDILFLE DEHLYLGDAS DLRLPISPEA MANLTYTSGT TGTPKGNMVS HRNILRTVKN 1690 1700 1710 1720 1730 1740 TNYLDVMTSD IVLSISNYVF DAFMFDVFGS LLNGAKLVIA PKDTILDMSR LAHVLEKEKV 1750 1760 1770 1780 1790 1800 TVLMITTALF NLLTDMRPDS LKGLRRVLFG GERASVDHVR RALNTVGKGR LLHMYGPSES 1810 1820 1830 1840 1850 1860 TVFTTYYPVN EVPDDAQAIP IGKPVSNTEV LILDSFGNVQ PAGVAGELCV GGDGLVRGYF 1870 1880 1890 1900 1910 1920 NRPELTAEKF TEHPFKTGEK IYRTGDMARW LADGCLEFIG RIDHQVKIRG QRIELGEIEH 1930 1940 1950 1960 1970 1980 HLVTHEMVQE AAVLAVDTGK RDQMICAYFT ADQELSSEEL RRYAAEGLPG YMIPSVFMQL 1990 2000 2010 2020 2030 2040 QELPLTGNGK VDRRALPEPD VTQAAQKEYT APRSRTGAQL ADLWQEVLNV PKIGVHDNFF 2050 2060 2070 2080 2090 2100 ELGGHSLIGM TLIARIQQEM NVDLQLKDLF QAPTIETLAQ AAEKTEKKSA VYIEAVPDRD 2110 2120 2130 2140 2150 2160 TYPVSSAQKR LYVLQQIEGA EKSYHMPAVL QLEGKLDLKR LESAAQMLIK RHEAFRTTFE 2170 2180 2190 2200 2210 2220 IKDGEPVQRI WEAAELTIDV IDADEQEAEK LIKEFIRPFD LTKAPLFRMS IIRFTGEKHL 2230 2240 2250 2260 2270 2280 LLVDMHHIIS DGASVSVLID EMTKLYAGEA LEPLRIQYKD FSVWQQHLLT ERHKVQEEYW 2290 2300 2310 2320 2330 2340 LKELAGELPV LTLPADYPRP SIQTFEGSRL SFALKPELVQ QLRKLAKETD STLYMVLAAS 2350 2360 2370 2380 2390 2400 YSALLSKLSG QSEVIVGSPA AGRPHTDLNR IIGMFVNTLA IRTRPEGDKP FSAFLEEVKE 2410 2420 2430 2440 2450 2460 TTLGAFEHQD YPFEELIEKL NIQRDMSRNP LFDAVFSMRN ADLKDLSMEG ITLKPYDFAH 2470 2480 2490 2500 2510 2520 QTAKFDLTLT AAEEDGLLVF EMEYNTALFK HESIERWRGY WVNLLEAVAE NPDARLSELS 2530 2540 2550 2560 2570 2580 LLDEAEKRRI VQNWNETRLA VPQDKTVHEL FEAQVLRTPD RGAAVYNGVK WTYKELNARA 2590 2600 2610 2620 2630 2640 NRLARLLIEK GARPEQRIGI MVKPSLEMAA GVLAILKAGA AYVPIDPSYP AERIGYVLKD 2650 2660 2670 2680 2690 2700 SGAELLLTQT NLAAPEEFSG ETLLLDSMLS EEITKDDEVN PQAGTQSDNL AYLIYTSGTT 2710 2720 2730 2740 2750 2760 GQPKGVMVEH RSLVNLCYWH NDAFKVTEQD KSAKYAGFGF DASVWEMFPY WIAGAELHII 2770 2780 2790 2800 2810 2820 DEAIRMDITR LNQYFEENKI TITFLPTQLC EQFMELDNQS LRVLLTGGDK LKRIAKRSYT 2830 2840 2850 2860 2870 2880 LVNNYGPTEN TVVATSTAID PDKGMLSIGK PIANTRAYVL GQNNEVQPVG VAGELCIAAR 2890 2900 2910 2920 2930 2940 GLARGYLNKP EETAKRFTED PFVPGERMYR TGDAVKWLED GRLEYIGRID QQVKIRGFRI 2950 2960 2970 2980 2990 3000 ELSEIEVQLA RLSEVQEAVV TDIEDACGNK ALCGYVVANE QLDTESLARK LAQTLPDYMV 3010 3020 3030 3040 3050 3060 PSFWVQLKEL PVTANGKVDR RALPQPDVEA QTAEYKAPLT ETEQLLADIW QEVLGIDRIG 3070 3080 3090 3100 3110 3120 ITDNFFALGG DSIKGIQMAS RLQQHGWKLE MKDLFQHPTI GELSAYVQAA DDQPIDQNPV 3130 3140 3150 3160 3170 3180 EGEVTLTPIQ RWFFERRFTN EHHWNQSVML HALTGFDPET AGKALSKLIE HHDALRMVYQ 3190 3200 3210 3220 3230 3240 RNGDGIVQYN RGLEETAVRP EVIRFNESGA ELEAAVLKAS NRIQSSIDLT EGPLLKAAIF 3250 3260 3270 3280 3290 3300 KTDQGDHLLI VIHHLVVDGI SWRILLEDFA AGYAQAEKGE PIILQDKTHS FAEYAARLEE 3310 3320 3330 3340 3350 3360 YAGSKAFAKE IGYWQEIEQA ETAALPKDDE AEDKRMRHTK TAEFSLSKEE TEQLMTKVHE 3370 3380 3390 3400 3410 3420 AYNTEMNDIL LTALGLALKE WTGQEDFIIC LEGHGREDII DGLNISRTVG WFTSQFPALI 3430 3440 3450 3460 3470 3480 QMRHSGDIGY QIKQIKEELR HIPNKGIGYG IYRYLTEEGK KAQPIKHDIS FNYLGQFTEM 3490 3500 3510 3520 3530 3540 ADSGLFTRST LPSGDPLSPE TEKPNALDIV GYIEDGILTM SIAYHSLEYK ESTVAAVAAS 3550 3560 3570 3580 FKTYLLQLID HCLERDGGEL TPSDLGDDEL TLEELDKLME IF

References

[1]	"Molecular and biochemical characterization of the protein template controlling biosynthesis of the lipopeptide lichenysin." Konz D., Doekel S., Marahiel M.A. J. Bacteriol. 181:133-140(1999) [PubMed: 9864322] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 10716 EMBL AAD04757.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95370 Genomic DNA. Translation: AAD04757.1.
3D structure databases
HSSP	HSSP built from PDB template 1DNY based on UniProtKB O30409.
ProteinModelPortal	O66069.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR023213. CAT-like_dom. IPR001242. Condensatn. IPR010060. NRPS_synth. IPR006163. Phsphopanteth-bd. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 3 hits. G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
Pfam	PF00501. AMP-binding. 3 hits. PF00668. Condensation. 4 hits. PF00550. PP-binding. 3 hits. [Graphical view]
SMART	SM00823. PKS_PP. 3 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 3 hits.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 3 hits. TIGR01720. NRPS-para261. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 3 hits. PS00455. AMP_BINDING. 3 hits. PS00012. PHOSPHOPANTETHEINE. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O66069_BACLI

Accession

Primary (citable) accession number: O66069

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	September 21, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)