Reviewed, UniProtKB/Swiss-Prot O65992 (MTLD_CLOAB)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	CA_C0157

Organism

Clostridium acetobutylicum [Complete proteome] [HAMAP]

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170702
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	O65992-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 0F73B98AFD9B8F6C	FASTA	384	43,922
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGYLL YKSNYETTFV DIFDKVVDDI NKYKRYTVIT LSTSKNKEKV 70 80 90 100 110 120 ENVRAVNLKD SVALEKEVLE ADLITTSLGL NNLKSTGELL RGFLKKRSEI NDKPLDIIAC 130 140 150 160 170 180 ENALFASDVL KKAILDGADE ELKKYLEKSV GFPNCTVDRI VPNVDIEKEL PIDVAVEDFY 190 200 210 220 230 240 EWDIEKNKVK INNKIIGAEY VEKLDPYLER KLFLLNGAHA TIAYLGYLKG YKYIHEAIKD 250 260 270 280 290 300 KEINKIIVGF HSEAVQALSE KHKIDIQILK EYSNKLLKRF ENEYLKDDVS RVGRDPMRKL 310 320 330 340 350 360 SSNDRLITPL KLCCDLKIDF TNILFGVASG YLFNYKEDEK AQGIQNIITK EGIKKAISNV 370 380 SQIKEGDYLN NMIAYKYEEL KKQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator." Behrens S., Mitchell W.J., Bahl H. Microbiology 147:75-86(2001) [PubMed: 11160802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[2]	"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U53868 Genomic DNA. Translation: AAC12851.1. AE001437 Genomic DNA. Translation: AAK78141.1.
PIR	B96919.
RefSeq	NP_346801.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1116340.
GenomeReviews	Gene locus CA_C0157 in contig AE001437_GR.
KEGG	cac:CAC0157.
NMPDR	fig|272562.1.peg.330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O65992.
Enzyme and pathway databases
BioCyc	CACE272562:CAC0157-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_CLOAB

Accession

Primary (citable) accession number: O65992

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)