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Protein

Mannitol-1-phosphate 5-dehydrogenase

Gene

mtlD

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 14NADBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol-1-phosphate 5-dehydrogenase (EC:1.1.1.17)
Gene namesi
Name:mtlD
Ordered Locus Names:CA_C0157
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707021 – 384Mannitol-1-phosphate 5-dehydrogenaseAdd BLAST384

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C0157.

Structurei

3D structure databases

ProteinModelPortaliO65992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4107QZW. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000271391.
KOiK00009.
OMAiQHHEDPL.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
HAMAPiMF_00196. Mannitol_dehydrog. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALHFGAGN IGRGFIGYLL YKSNYETTFV DIFDKVVDDI NKYKRYTVIT
60 70 80 90 100
LSTSKNKEKV ENVRAVNLKD SVALEKEVLE ADLITTSLGL NNLKSTGELL
110 120 130 140 150
RGFLKKRSEI NDKPLDIIAC ENALFASDVL KKAILDGADE ELKKYLEKSV
160 170 180 190 200
GFPNCTVDRI VPNVDIEKEL PIDVAVEDFY EWDIEKNKVK INNKIIGAEY
210 220 230 240 250
VEKLDPYLER KLFLLNGAHA TIAYLGYLKG YKYIHEAIKD KEINKIIVGF
260 270 280 290 300
HSEAVQALSE KHKIDIQILK EYSNKLLKRF ENEYLKDDVS RVGRDPMRKL
310 320 330 340 350
SSNDRLITPL KLCCDLKIDF TNILFGVASG YLFNYKEDEK AQGIQNIITK
360 370 380
EGIKKAISNV SQIKEGDYLN NMIAYKYEEL KKQN
Length:384
Mass (Da):43,922
Last modified:August 1, 1998 - v1
Checksum:i0F73B98AFD9B8F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53868 Genomic DNA. Translation: AAC12851.1.
AE001437 Genomic DNA. Translation: AAK78141.1.
PIRiB96919.
RefSeqiNP_346801.1. NC_003030.1.
WP_010963483.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78141; AAK78141; CA_C0157.
GeneIDi1116340.
KEGGicac:CA_C0157.
PATRICi32034607. VBICloAce74127_0341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53868 Genomic DNA. Translation: AAC12851.1.
AE001437 Genomic DNA. Translation: AAK78141.1.
PIRiB96919.
RefSeqiNP_346801.1. NC_003030.1.
WP_010963483.1. NC_003030.1.

3D structure databases

ProteinModelPortaliO65992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C0157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK78141; AAK78141; CA_C0157.
GeneIDi1116340.
KEGGicac:CA_C0157.
PATRICi32034607. VBICloAce74127_0341.

Phylogenomic databases

eggNOGiENOG4107QZW. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000271391.
KOiK00009.
OMAiQHHEDPL.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
HAMAPiMF_00196. Mannitol_dehydrog. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTLD_CLOAB
AccessioniPrimary (citable) accession number: O65992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.