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O65976

- BLC6_SALTM

UniProt

O65976 - BLC6_SALTM

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Protein
Beta-lactamase CTX-M-6
Gene
bla
Organism
Salmonella typhimurium
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has cefotaxime-hydrolyzing activity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase CTX-M-6 (EC:3.5.2.6)
Alternative name(s):
Cefotaximase 6
Gene namesi
Name:bla
Encoded oniPlasmid pAS310 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 By similarity
Add
BLAST
Chaini29 – 291263Beta-lactamase CTX-M-6
PRO_0000016993Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO65976.
SMRiO65976. Positions 31-291.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2393Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65976-1 [UniParc]FASTAAdd to Basket

« Hide

MMTQSIRRSM LTVMATLPLL FSSATLHAQA NSVQQQLEAL EKSSGGRLGV    50
ALINTADNSQ ILYVADERFA MCSTSKVMAA AAVLKQSESD KHLLNQRVEI 100
RASDLVNYNP IAEKHVNGTM TLAQLGAGAL QYSDNTAMNK LIAHLGGPDK 150
VTAFARSLGD ETFRLDRTEP TLNSAIPGDP RDTTTPLAMA QTLKNLTLGK 200
ALAETQRAQL VTWLKGNTTG SASIRAGLPK SWGVGDKTGS GDYGTTNDIA 250
VIWPENHAPL VLVTYFTQPE QKAESRRDVL AAAAKIVTHG F 291
Length:291
Mass (Da):31,207
Last modified:August 1, 1998 - v1
Checksum:iDC95E4FE77531053
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005045 Genomic DNA. Translation: CAA06312.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005045 Genomic DNA. Translation: CAA06312.1 .

3D structure databases

ProteinModelPortali O65976.
SMRi O65976. Positions 31-291.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two novel plasmid-mediated cefotaxime-hydrolyzing beta-lactamases (CTX-M-5 and CTX-M-6) from Salmonella typhimurium."
    Gazouli M., Tzelepi E., Markogiannakis A., Legakis N.J., Tzouvelekis L.S.
    FEMS Microbiol. Lett. 165:289-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AS31.

Entry informationi

Entry nameiBLC6_SALTM
AccessioniPrimary (citable) accession number: O65976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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