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O65975

- BLC5_SALTM

UniProt

O65975 - BLC5_SALTM

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Protein

Beta-lactamase CTX-M-5

Gene

bla

Organism
Salmonella typhimurium
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has cefotaxime-hydrolyzing activity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase CTX-M-5 (EC:3.5.2.6)
Alternative name(s):
Cefotaximase 5
Gene namesi
Name:bla
Encoded oniPlasmid pAS300 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 291263Beta-lactamase CTX-M-5PRO_0000016992Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO65975.
SMRiO65975. Positions 31-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2393Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65975-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMTQSIRRSM LTVMATLPLL FSSATLHAQA NSVQQQLEAL EKSSGGRLGV
60 70 80 90 100
ALINTADNSQ ILYLADERFA MCSTSKVMAA AAVLKQSESD KHLLNQRVEI
110 120 130 140 150
KASDLVNYNP IAEKHVNGTM TLAELGAGAL QYSDNTAMNK LIAHLGGPDK
160 170 180 190 200
VTAFARSLGD ETFRLDRTEP TLNSAIPGDP RDTTTPLAMA QTLKNLTLGK
210 220 230 240 250
ALAETQRAQL VTWLKGNTTG SASIRAGLPK CWVVGDKTGS GDYGTTNDIA
260 270 280 290
VIWPENHAPL VLVTYFTQPE QKAESRRDVL AAAAKIVTHG F
Length:291
Mass (Da):31,252
Last modified:August 1, 1998 - v1
Checksum:iDCC1C3F73789894E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005044 Genomic DNA. Translation: CAA06311.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005044 Genomic DNA. Translation: CAA06311.1 .

3D structure databases

ProteinModelPortali O65975.
SMRi O65975. Positions 31-291.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two novel plasmid-mediated cefotaxime-hydrolyzing beta-lactamases (CTX-M-5 and CTX-M-6) from Salmonella typhimurium."
    Gazouli M., Tzelepi E., Markogiannakis A., Legakis N.J., Tzouvelekis L.S.
    FEMS Microbiol. Lett. 165:289-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AS30.

Entry informationi

Entry nameiBLC5_SALTM
AccessioniPrimary (citable) accession number: O65975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3