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O65872 (CHSY_PINST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismPinus strobus (Eastern white pine)
Taxonomic identifier3348 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaePinusStrobus

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Chalcone synthase
PRO_0000216041

Sites

Active site1691 By similarity

Sequences

Sequence LengthMass (Da)Tools
O65872 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 45E0A370189A4626

FASTA39543,207
        10         20         30         40         50         60 
MPGGMMADLE AFRKAQRADG PATILAIGTA TPPNAVDQST YPDYYFKITN SEHMTELKEK 

        70         80         90        100        110        120 
FRRMCDKSGI KKRYMYLTEE ILNENPSVCA YMAPSLDARQ DMVVVEVPRL GKEAAAKAIK 

       130        140        150        160        170        180 
EWGQPKSKIT HVIFCTTSGV DMPGADYQMT KLLGLRPSVK RVMMYQQGCF AGGTVLRVAK 

       190        200        210        220        230        240 
DLAENNRGAR VLVVCSEITA VTFRGPSDTH LDSMVGQALF GDGARALIVG ADPVPEVEKP 

       250        260        270        280        290        300 
CFEMLWTAQT ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLVE AFQQFGISDW 

       310        320        330        340        350        360 
NQLFWIAHPG GPAILDQVEA KLNLDPKKLR ATRQVLSEYG NMSSACVHFI LDEMRKSSQQ 

       370        380        390 
NGCSTTGEGL DVGVLFGFGP GLTVETVVLK SVPLQ 

« Hide

References

[1]"Plant polyketide synthases: a chalcone synthase-type enzyme that performs with methylmalonyl-CoA a specific condensation reaction in the biosynthesis of C-methylated chalcones."
Schroeder J.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ004800 mRNA. Translation: CAA06077.1.

3D structure databases

ProteinModelPortalO65872.
SMRO65872. Positions 13-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_PINST
AccessionPrimary (citable) accession number: O65872
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: August 1, 1998
Last modified: March 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways