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Protein

Histone H2B.1

Gene

H2B-1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Caution

To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK33ac = acetylated Lys-33; H2BK34ac = acetylated Lys-34; H2BK143ub1 = monoubiquitinated Lys-138.Curated

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B.1
Alternative name(s):
LeH2B-1
Gene namesi
Name:H2B-1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002404492 – 142Histone H2B.1Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei33N6-acetyllysineBy similarity1
Modified residuei34N6-acetyllysineBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Can be acetylated to form H2BK6ac, H2BK33ac and H2BK34ac.By similarity
Monoubiquitinated to form H2BK143ub1; may give a specific tag for epigenetic transcriptional activation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO65821
PRIDEiO65821

Expressioni

Tissue specificityi

Ubiquitous. Highest level in shoots, fruits and young flower buds, including petals, anthers and ovules.1 Publication

Inductioni

By gibberellins GA1, GA3, GA4 and GA9.1 Publication

Gene expression databases

ExpressionAtlasiO65821 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4081.Solyc06g074790.1.1

Structurei

3D structure databases

ProteinModelPortaliO65821
SMRiO65821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
InParanoidiO65821
KOiK11252
OMAiYTSANLE
OrthoDBiEOG09360WOA

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAGKKPA EKKPVEEKKA EEVPAEKKPK AGKKLPKDAG ADKKKKKSKK
60 70 80 90 100
SVETYKIYIF KVLKQVHPDI GISSKSMGIM NSFINDIFEK LAQESSRLAR
110 120 130 140
INKKPTITSR EIQTAVRLVL PGELAKHAVS EGTKAVTKFT SN
Length:142
Mass (Da):15,671
Last modified:January 23, 2007 - v4
Checksum:i9890EFF6A90A909F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224934 mRNA Translation: CAA12233.1
PIRiT06393
RefSeqiNP_001233989.1, NM_001247060.1
UniGeneiLes.4442

Genome annotation databases

EnsemblPlantsiSolyc06g074790.1.1; Solyc06g074790.1.1; Solyc06g074790.1
GeneIDi778282
GrameneiSolyc06g074790.1.1; Solyc06g074790.1.1; Solyc06g074790.1
KEGGisly:778282

Similar proteinsi

Entry informationi

Entry nameiH2B1_SOLLC
AccessioniPrimary (citable) accession number: O65821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 86 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health