O65812 (PROF1_HEVBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Profilin-1 Alternative name(s): Pollen allergen Hev b 8.0101 Allergen=Hev b 8.0101
Organism	Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifier	3981 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Euphorbiaceae › Crotonoideae › Micrandreae › Hevea

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human. Involved in latex allergic reactions. Ref.1
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-1		PRO_0000199633

Sequences

	Sequence		Length	Mass (Da)
	O65812 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 5CB0D7DA0CFCDEFA	FASTA	131	14,194
	10 20 30 40 50 60 MSWQTYVDER LMCEIEGNHL TAAAIIGQDG SVWAQSSNFP QFKSEEITAI MSDFDEPGTL 70 80 90 100 110 120 APTGLHLGGT KYMVIQGEAG AVIRGKKGPG GVTVRKTNQA LIIGIYDEPM TPGQCNMIVE 130 RLGDYLLEQG M

References

[1]

"Assessment of profilin as an allergen for latex-sensitized patients." Nieto A., Mazon A., Boquete M., Carballada F., Asturias J.A., Martinez J., Martinez A., Palacios R. Allergy 57:776-784(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Strain: cv. RRIC 133. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y15042 mRNA. Translation: CAA75312.1.
PIR	T10769.
3D structure databases
ProteinModelPortal	O65812.
SMR	O65812. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	397. Hev b 8. 398. Hev b 8.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF1_HEVBR

Accession

Primary (citable) accession number: O65812

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program