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O65810 (PROF2_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin-2
Alternative name(s):
GmPRO2
Allergen=Gly m 3.0102
Gene names
Name:PRO2
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Allergenic properties

Causes an allergic reaction in human. Ref.1

Sequence similarities

Belongs to the profilin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DiseaseAllergen
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 131130Profilin-2
PRO_0000199673

Sequences

Sequence LengthMass (Da)Tools
O65810 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: AE9B9517AE9166BE

FASTA13114,100
        10         20         30         40         50         60 
MSWQAYVDDH LLCGIEGNHL THAAIIGQDG SVWLQSTDFP QFKPEEITAI MNDFNEPGSL 

        70         80         90        100        110        120 
APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKTGAA LIIGIYDEPM TPGQCNMVVE 

       130 
RLGDYLIDQG Y 

« Hide

References

[1]"IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes."
Rihs H.-P., Chen Z., Rueff F., Petersen A., Rozynek P., Heimann H., Baur X.
J. Allergy Clin. Immunol. 104:1293-1301(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ223981 mRNA. Translation: CAA11755.1.
PIRT07773.
RefSeqNP_001236192.1. NM_001249263.1.
UniGeneGma.54807.

3D structure databases

ProteinModelPortalO65810.
SMRO65810. Positions 2-130.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome372. Gly m 3.
374. Gly m 3.0102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID547670.
KEGGgmx:547670.

Phylogenomic databases

KOK05759.

Gene expression databases

GenevestigatorO65810.

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROF2_SOYBN
AccessionPrimary (citable) accession number: O65810
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries