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O65810

- PROF2_SOYBN

UniProt

O65810 - PROF2_SOYBN

Protein

Profilin-2

Gene

PRO2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-2
    Alternative name(s):
    GmPRO2
    Allergen: Gly m 3.0102
    Gene namesi
    Name:PRO2
    OrganismiGlycine max (Soybean) (Glycine hispida)
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Unplaced

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei372. Gly m 3.
    374. Gly m 3.0102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 131130Profilin-2PRO_0000199673Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriO65810.

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Structurei

    3D structure databases

    ProteinModelPortaliO65810.
    SMRiO65810. Positions 2-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Phylogenomic databases

    KOiK05759.

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O65810-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LLCGIEGNHL THAAIIGQDG SVWLQSTDFP QFKPEEITAI    50
    MNDFNEPGSL APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKTGAA 100
    LIIGIYDEPM TPGQCNMVVE RLGDYLIDQG Y 131
    Length:131
    Mass (Da):14,100
    Last modified:August 1, 1998 - v1
    Checksum:iAE9B9517AE9166BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223981 mRNA. Translation: CAA11755.1.
    PIRiT07773.
    RefSeqiNP_001236192.1. NM_001249263.1.
    UniGeneiGma.54807.

    Genome annotation databases

    GeneIDi547670.
    KEGGigmx:547670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223981 mRNA. Translation: CAA11755.1 .
    PIRi T07773.
    RefSeqi NP_001236192.1. NM_001249263.1.
    UniGenei Gma.54807.

    3D structure databases

    ProteinModelPortali O65810.
    SMRi O65810. Positions 2-130.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 372. Gly m 3.
    374. Gly m 3.0102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 547670.
    KEGGi gmx:547670.

    Phylogenomic databases

    KOi K05759.

    Gene expression databases

    Genevestigatori O65810.

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes."
      Rihs H.-P., Chen Z., Rueff F., Petersen A., Rozynek P., Heimann H., Baur X.
      J. Allergy Clin. Immunol. 104:1293-1301(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

    Entry informationi

    Entry nameiPROF2_SOYBN
    AccessioniPrimary (citable) accession number: O65810
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3