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O65810

- PROF2_SOYBN

UniProt

O65810 - PROF2_SOYBN

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Protein

Profilin-2

Gene

PRO2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-2
Alternative name(s):
GmPRO2
Allergen: Gly m 3.0102
Gene namesi
Name:PRO2
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei372. Gly m 3.
374. Gly m 3.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 131130Profilin-2PRO_0000199673Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriO65810.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structurei

3D structure databases

ProteinModelPortaliO65810.
SMRiO65810. Positions 2-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

InParanoidiO65810.
KOiK05759.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65810-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LLCGIEGNHL THAAIIGQDG SVWLQSTDFP QFKPEEITAI
60 70 80 90 100
MNDFNEPGSL APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKTGAA
110 120 130
LIIGIYDEPM TPGQCNMVVE RLGDYLIDQG Y
Length:131
Mass (Da):14,100
Last modified:August 1, 1998 - v1
Checksum:iAE9B9517AE9166BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223981 mRNA. Translation: CAA11755.1.
PIRiT07773.
RefSeqiNP_001236192.1. NM_001249263.1.
UniGeneiGma.54807.

Genome annotation databases

GeneIDi547670.
KEGGigmx:547670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223981 mRNA. Translation: CAA11755.1 .
PIRi T07773.
RefSeqi NP_001236192.1. NM_001249263.1.
UniGenei Gma.54807.

3D structure databases

ProteinModelPortali O65810.
SMRi O65810. Positions 2-130.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 372. Gly m 3.
374. Gly m 3.0102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 547670.
KEGGi gmx:547670.

Phylogenomic databases

InParanoidi O65810.
KOi K05759.

Gene expression databases

Genevestigatori O65810.

Family and domain databases

InterProi IPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes."
    Rihs H.-P., Chen Z., Rueff F., Petersen A., Rozynek P., Heimann H., Baur X.
    J. Allergy Clin. Immunol. 104:1293-1301(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Entry informationi

Entry nameiPROF2_SOYBN
AccessioniPrimary (citable) accession number: O65810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3