O65810 (PROF2_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-2

Alternative name(s):
GmPRO2
Allergen=Gly m 3.0102

Gene names

Name:

PRO2

Organism

Glycine max (Soybean) (Glycine hispida) [Reference proteome]

Taxonomic identifier

3847 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-2		PRO_0000199673

Sequences

	Sequence		Length	Mass (Da)
	O65810 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: AE9B9517AE9166BE	FASTA	131	14,100
	10 20 30 40 50 60 MSWQAYVDDH LLCGIEGNHL THAAIIGQDG SVWLQSTDFP QFKPEEITAI MNDFNEPGSL 70 80 90 100 110 120 APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKTGAA LIIGIYDEPM TPGQCNMVVE 130 RLGDYLIDQG Y

References

[1]

"IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes." Rihs H.-P., Chen Z., Rueff F., Petersen A., Rozynek P., Heimann H., Baur X. J. Allergy Clin. Immunol. 104:1293-1301(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223981 mRNA. Translation: CAA11755.1.
PIR	T07773.
RefSeq	NP_001236192.1. NM_001249263.1.
UniGene	Gma.54807.
3D structure databases
ProteinModelPortal	O65810.
SMR	O65810. Positions 2-130.
ModBase	Search...
Protein family/group databases
Allergome	372. Gly m 3. 374. Gly m 3.0102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	547670.
KEGG	gmx:547670.
Phylogenomic databases
KO	K05759.
Gene expression databases
Genevestigator	O65810.
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF2_SOYBN

Accession

Primary (citable) accession number: O65810

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program