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Protein

Delta-9 acyl-lipid desaturase 1

Gene

ADS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in delta-9 desaturation of fatty acids.3 Publications

Cofactori

Fe cationBy similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciARA:AT1G06080-MONOMER.
ReactomeiR-ATH-75105. Fatty Acyl-CoA Biosynthesis.
UniPathwayiUPA00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-9 acyl-lipid desaturase 1 (EC:1.14.19.-)
Gene namesi
Name:ADS1
Ordered Locus Names:At1g06080
ORF Names:T21E18.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G06080.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854251 – 305Delta-9 acyl-lipid desaturase 1Add BLAST305

Proteomic databases

PaxDbiO65797.

Expressioni

Tissue specificityi

Strongly expressed in inflorescence meristems, leaves, and flowers, and weakly in roots and seedpods.1 Publication

Inductioni

Down-regulated by cold.1 Publication

Gene expression databases

GenevisibleiO65797. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G06080.1.

Structurei

3D structure databases

ProteinModelPortaliO65797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 88Histidine box-16
Motifi120 – 124Histidine box-25
Motifi252 – 256Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1600. Eukaryota.
COG1398. LUCA.
HOGENOMiHOG000270353.
InParanoidiO65797.
OMAiHHAFSDA.
OrthoDBiEOG09360DCM.
PhylomeDBiO65797.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.

Sequencei

Sequence statusi: Complete.

O65797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSASEKEE NNKKMAADKA EMGRKKRAMW ERKWKRLDIV KAFASLFVHF
60 70 80 90 100
LCLLAPFNFT WPALRVALIV YTVGGLGITV SYHRNLAHRS FKVPKWLEYF
110 120 130 140 150
FAYCGLLAIQ GDPIDWVSTH RYHHQFTDSD RDPHSPNEGF WFSHLLWLFD
160 170 180 190 200
TGYLVEKCGR RTNVEDLKRQ WYYKFLQRTV LYHILTFGFL LYYFGGLSFL
210 220 230 240 250
TWGMGIGVAM EHHVTCLINS LCHVWGSRTW KTNDTSRNVW WLSVFSFGES
260 270 280 290 300
WHNNHHAFES SARQGLEWWQ IDISWYIVRF LEIIGLATDV KLPSESQRRR

MAMVR
Length:305
Mass (Da):36,107
Last modified:August 1, 1998 - v1
Checksum:i0BDABE2162AFC2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154L → R in BAC43716 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88536 mRNA. Translation: BAA25180.1.
AC024174 Genomic DNA. Translation: AAF80131.1.
CP002684 Genomic DNA. Translation: AEE27937.1.
AK119146 mRNA. Translation: BAC43716.1.
AF332433 mRNA. Translation: AAG48796.1.
PIRiT52111.
RefSeqiNP_172098.1. NM_100489.4.
UniGeneiAt.342.

Genome annotation databases

EnsemblPlantsiAT1G06080.1; AT1G06080.1; AT1G06080.
GeneIDi837117.
GrameneiAT1G06080.1; AT1G06080.1; AT1G06080.
KEGGiath:AT1G06080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88536 mRNA. Translation: BAA25180.1.
AC024174 Genomic DNA. Translation: AAF80131.1.
CP002684 Genomic DNA. Translation: AEE27937.1.
AK119146 mRNA. Translation: BAC43716.1.
AF332433 mRNA. Translation: AAG48796.1.
PIRiT52111.
RefSeqiNP_172098.1. NM_100489.4.
UniGeneiAt.342.

3D structure databases

ProteinModelPortaliO65797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G06080.1.

Proteomic databases

PaxDbiO65797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G06080.1; AT1G06080.1; AT1G06080.
GeneIDi837117.
GrameneiAT1G06080.1; AT1G06080.1; AT1G06080.
KEGGiath:AT1G06080.

Organism-specific databases

TAIRiAT1G06080.

Phylogenomic databases

eggNOGiKOG1600. Eukaryota.
COG1398. LUCA.
HOGENOMiHOG000270353.
InParanoidiO65797.
OMAiHHAFSDA.
OrthoDBiEOG09360DCM.
PhylomeDBiO65797.

Enzyme and pathway databases

UniPathwayiUPA00658.
BioCyciARA:AT1G06080-MONOMER.
ReactomeiR-ATH-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiO65797.

Gene expression databases

GenevisibleiO65797. AT.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
ProtoNetiSearch...

Entry informationi

Entry nameiADS1_ARATH
AccessioniPrimary (citable) accession number: O65797
Secondary accession number(s): Q8GW15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Substrate specificity shifts from delta-9 to delta-7 desaturation when the protein is retargeted to the chloroplast.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.