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Protein

Delta-9 acyl-lipid desaturase 1

Gene

ADS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in delta-9 desaturation of fatty acids.3 Publications

Miscellaneous

Substrate specificity shifts from delta-9 to delta-7 desaturation when the protein is retargeted to the chloroplast.

Cofactori

Fe cationBy similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • unsaturated fatty acid biosynthetic process Source: GO_Central
  • very long-chain fatty acid biosynthetic process Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron

Enzyme and pathway databases

BioCyciARA:AT1G06080-MONOMER
ReactomeiR-ATH-75105 Fatty acyl-CoA biosynthesis
UniPathwayiUPA00658

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-9 acyl-lipid desaturase 1 (EC:1.14.19.-)
Gene namesi
Name:ADS1
Ordered Locus Names:At1g06080
ORF Names:T21E18.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G06080
TAIRilocus:2198786 AT1G06080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854251 – 305Delta-9 acyl-lipid desaturase 1Add BLAST305

Proteomic databases

PaxDbiO65797

Expressioni

Tissue specificityi

Strongly expressed in inflorescence meristems, leaves, and flowers, and weakly in roots and seedpods.1 Publication

Inductioni

Down-regulated by cold.1 Publication

Gene expression databases

ExpressionAtlasiO65797 baseline and differential
GenevisibleiO65797 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G06080.1

Structurei

3D structure databases

ProteinModelPortaliO65797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 88Histidine box-16
Motifi120 – 124Histidine box-25
Motifi252 – 256Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1600 Eukaryota
COG1398 LUCA
HOGENOMiHOG000270353
InParanoidiO65797
OMAiCQHGPID
OrthoDBiEOG09360DCM
PhylomeDBiO65797

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE

Sequencei

Sequence statusi: Complete.

O65797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSASEKEE NNKKMAADKA EMGRKKRAMW ERKWKRLDIV KAFASLFVHF
60 70 80 90 100
LCLLAPFNFT WPALRVALIV YTVGGLGITV SYHRNLAHRS FKVPKWLEYF
110 120 130 140 150
FAYCGLLAIQ GDPIDWVSTH RYHHQFTDSD RDPHSPNEGF WFSHLLWLFD
160 170 180 190 200
TGYLVEKCGR RTNVEDLKRQ WYYKFLQRTV LYHILTFGFL LYYFGGLSFL
210 220 230 240 250
TWGMGIGVAM EHHVTCLINS LCHVWGSRTW KTNDTSRNVW WLSVFSFGES
260 270 280 290 300
WHNNHHAFES SARQGLEWWQ IDISWYIVRF LEIIGLATDV KLPSESQRRR

MAMVR
Length:305
Mass (Da):36,107
Last modified:August 1, 1998 - v1
Checksum:i0BDABE2162AFC2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154L → R in BAC43716 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88536 mRNA Translation: BAA25180.1
AC024174 Genomic DNA Translation: AAF80131.1
CP002684 Genomic DNA Translation: AEE27937.1
AK119146 mRNA Translation: BAC43716.1
AF332433 mRNA Translation: AAG48796.1
PIRiT52111
RefSeqiNP_172098.1, NM_100489.4
UniGeneiAt.342

Genome annotation databases

EnsemblPlantsiAT1G06080.1; AT1G06080.1; AT1G06080
GeneIDi837117
GrameneiAT1G06080.1; AT1G06080.1; AT1G06080
KEGGiath:AT1G06080

Similar proteinsi

Entry informationi

Entry nameiADS1_ARATH
AccessioniPrimary (citable) accession number: O65797
Secondary accession number(s): Q8GW15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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