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O65735

- ALF_CICAR

UniProt

O65735 - ALF_CICAR

Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme

Gene

ALDC

Organism
Cicer arietinum (Chickpea) (Garbanzo)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521Substrate
    Binding sitei142 – 1421Substrate
    Active sitei184 – 1841Proton acceptorBy similarity
    Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-P
    Sitei359 – 3591Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase, cytoplasmic isozyme (EC:4.1.2.13)
    Gene namesi
    Name:ALDC
    OrganismiCicer arietinum (Chickpea) (Garbanzo)
    Taxonomic identifieri3827 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeCicereaeCicer

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Fructose-bisphosphate aldolase, cytoplasmic isozymePRO_0000216920Add
    BLAST

    Proteomic databases

    PRIDEiO65735.
    ProMEXiO65735.

    Structurei

    3D structure databases

    ProteinModelPortaliO65735.
    SMRiO65735. Positions 11-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01623.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O65735-1 [UniParc]FASTAAdd to Basket

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    MSNFKSKYHD ELIANAAYIG TPGKGILAAD ESTGTIGKRL ASINVENVET    50
    NRRALRELLF TAPNVLQYLS GVILFEETLY QSTAAGKPFV DVLNEAGVLP 100
    GIKVDKGTVE LAGTDGETTT QGLDGLGARC AKYYEAGARF AKWRAVLKIG 150
    PNEPSLSILS IENAYGLARY AVICQENGLV PIVELEILVD GSHDIHKCAA 200
    ITERVLAATY KALSDHHVLL EGTLLKPNMV TPGSDSPKVA PEVVAEHTVR 250
    ALQRTVPAAV PAVVFLSGGQ SEEEATVNLN AINQVKGKKP WTLSFSFGRA 300
    LQQSTLKAWS GKEENVKNAQ DALLTRAKAN SEATLGTYKG NSQLGEGASE 350
    SLHVKDYKY 359
    Length:359
    Mass (Da):38,452
    Last modified:August 1, 1998 - v1
    Checksum:iDD68864B745A5195
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005041 mRNA. Translation: CAA06308.1.
    RefSeqiNP_001265896.1. NM_001278967.1.

    Genome annotation databases

    GeneIDi101501462.
    KEGGicam:101501462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005041 mRNA. Translation: CAA06308.1 .
    RefSeqi NP_001265896.1. NM_001278967.1.

    3D structure databases

    ProteinModelPortali O65735.
    SMRi O65735. Positions 11-359.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O65735.
    ProMEXi O65735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101501462.
    KEGGi cam:101501462.

    Phylogenomic databases

    KOi K01623.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino-acid sequence of a cytosolic aldolase from Cicer arietinum L. epicotyls."
      Dopico B., Munoz F.J., Labrador E.
      Plant Gene Register PGR98-110
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Castellana.
      Tissue: Etiolated epicotyl.

    Entry informationi

    Entry nameiALF_CICAR
    AccessioniPrimary (citable) accession number: O65735
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3