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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme

Gene

ALDC

Organism
Cicer arietinum (Chickpea) (Garbanzo)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Substrate
Binding sitei142 – 1421Substrate
Active sitei184 – 1841Proton acceptorBy similarity
Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-P
Sitei359 – 3591Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme (EC:4.1.2.13)
Gene namesi
Name:ALDC
OrganismiCicer arietinum (Chickpea) (Garbanzo)
Taxonomic identifieri3827 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeCicereaeCicer

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-bisphosphate aldolase, cytoplasmic isozymePRO_0000216920Add
BLAST

Proteomic databases

PRIDEiO65735.

Structurei

3D structure databases

ProteinModelPortaliO65735.
SMRiO65735. Positions 11-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01623.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFKSKYHD ELIANAAYIG TPGKGILAAD ESTGTIGKRL ASINVENVET
60 70 80 90 100
NRRALRELLF TAPNVLQYLS GVILFEETLY QSTAAGKPFV DVLNEAGVLP
110 120 130 140 150
GIKVDKGTVE LAGTDGETTT QGLDGLGARC AKYYEAGARF AKWRAVLKIG
160 170 180 190 200
PNEPSLSILS IENAYGLARY AVICQENGLV PIVELEILVD GSHDIHKCAA
210 220 230 240 250
ITERVLAATY KALSDHHVLL EGTLLKPNMV TPGSDSPKVA PEVVAEHTVR
260 270 280 290 300
ALQRTVPAAV PAVVFLSGGQ SEEEATVNLN AINQVKGKKP WTLSFSFGRA
310 320 330 340 350
LQQSTLKAWS GKEENVKNAQ DALLTRAKAN SEATLGTYKG NSQLGEGASE

SLHVKDYKY
Length:359
Mass (Da):38,452
Last modified:August 1, 1998 - v1
Checksum:iDD68864B745A5195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005041 mRNA. Translation: CAA06308.1.
RefSeqiNP_001265896.1. NM_001278967.1.

Genome annotation databases

GeneIDi101501462.
KEGGicam:101501462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005041 mRNA. Translation: CAA06308.1.
RefSeqiNP_001265896.1. NM_001278967.1.

3D structure databases

ProteinModelPortaliO65735.
SMRiO65735. Positions 11-359.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO65735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101501462.
KEGGicam:101501462.

Phylogenomic databases

KOiK01623.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA and deduced amino-acid sequence of a cytosolic aldolase from Cicer arietinum L. epicotyls."
    Dopico B., Munoz F.J., Labrador E.
    Plant Gene Register PGR98-110
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Castellana.
    Tissue: Etiolated epicotyl.

Entry informationi

Entry nameiALF_CICAR
AccessioniPrimary (citable) accession number: O65735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.