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O65735

- ALF_CICAR

UniProt

O65735 - ALF_CICAR

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Protein
Fructose-bisphosphate aldolase, cytoplasmic isozyme
Gene
ALDC
Organism
Cicer arietinum (Chickpea) (Garbanzo)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Substrate
Binding sitei142 – 1421Substrate
Active sitei184 – 1841Proton acceptor By similarity
Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-P
Sitei359 – 3591Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme (EC:4.1.2.13)
Gene namesi
Name:ALDC
OrganismiCicer arietinum (Chickpea) (Garbanzo)
Taxonomic identifieri3827 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeCicereaeCicer

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-bisphosphate aldolase, cytoplasmic isozyme
PRO_0000216920Add
BLAST

Proteomic databases

PRIDEiO65735.
ProMEXiO65735.

Structurei

3D structure databases

ProteinModelPortaliO65735.
SMRiO65735. Positions 11-359.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01623.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65735-1 [UniParc]FASTAAdd to Basket

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MSNFKSKYHD ELIANAAYIG TPGKGILAAD ESTGTIGKRL ASINVENVET    50
NRRALRELLF TAPNVLQYLS GVILFEETLY QSTAAGKPFV DVLNEAGVLP 100
GIKVDKGTVE LAGTDGETTT QGLDGLGARC AKYYEAGARF AKWRAVLKIG 150
PNEPSLSILS IENAYGLARY AVICQENGLV PIVELEILVD GSHDIHKCAA 200
ITERVLAATY KALSDHHVLL EGTLLKPNMV TPGSDSPKVA PEVVAEHTVR 250
ALQRTVPAAV PAVVFLSGGQ SEEEATVNLN AINQVKGKKP WTLSFSFGRA 300
LQQSTLKAWS GKEENVKNAQ DALLTRAKAN SEATLGTYKG NSQLGEGASE 350
SLHVKDYKY 359
Length:359
Mass (Da):38,452
Last modified:August 1, 1998 - v1
Checksum:iDD68864B745A5195
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005041 mRNA. Translation: CAA06308.1.
RefSeqiNP_001265896.1. NM_001278967.1.

Genome annotation databases

GeneIDi101501462.
KEGGicam:101501462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005041 mRNA. Translation: CAA06308.1 .
RefSeqi NP_001265896.1. NM_001278967.1.

3D structure databases

ProteinModelPortali O65735.
SMRi O65735. Positions 11-359.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O65735.
ProMEXi O65735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101501462.
KEGGi cam:101501462.

Phylogenomic databases

KOi K01623.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino-acid sequence of a cytosolic aldolase from Cicer arietinum L. epicotyls."
    Dopico B., Munoz F.J., Labrador E.
    Plant Gene Register PGR98-110
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Castellana.
    Tissue: Etiolated epicotyl.

Entry informationi

Entry nameiALF_CICAR
AccessioniPrimary (citable) accession number: O65735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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