Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclic nucleotide-gated ion channel 1

Gene

CNGC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K+, Na+ and Pb2+.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei557 – 5571cNMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi486 – 610125cNMPAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Protein family/group databases

TCDBi1.A.1.5.5. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated ion channel 1
Short name:
AtCNGC1
Alternative name(s):
Cyclic nucleotide- and calmodulin-regulated ion channel 1
Gene namesi
Name:CNGC1
Ordered Locus Names:At5g53130
ORF Names:MFH8.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G53130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9797CytoplasmicSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini119 – 13214ExtracellularSequence analysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini154 – 18734CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini209 – 22012ExtracellularSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini242 – 25918CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini281 – 37999ExtracellularSequence analysisAdd
BLAST
Transmembranei380 – 40021Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini401 – 716316CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Plants exhibit an improved tolerance to Pb2+.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Cyclic nucleotide-gated ion channel 1PRO_0000219329Add
BLAST

Proteomic databases

PaxDbiO65717.
PRIDEiO65717.

PTM databases

iPTMnetiO65717.

Expressioni

Tissue specificityi

Expressed in the whole plant but only weakly in roots.

Gene expression databases

GenevisibleiO65717. AT.

Interactioni

Subunit structurei

Homotetramer or heterotetramer (Potential). Binds calmodulin-2/3/5 with a higher affinity than calmodulin-1/4.Curated

Protein-protein interaction databases

BioGridi20638. 4 interactions.
STRINGi3702.AT5G53130.1.

Structurei

3D structure databases

ProteinModelPortaliO65717.
SMRiO65717. Positions 420-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini622 – 65130IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni602 – 61716Calmodulin-bindingAdd
BLAST

Domaini

The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 IQ domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO65717.
KOiK05391.
OMAiGQNMKTS.
OrthoDBiEOG09360404.
PhylomeDBiO65717.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFRQEKFVR FQDWKSDKTS SDVEYSGKNE IQTGIFQRTI SSISDKFYRS
60 70 80 90 100
FESSSARIKL FKRSYKSYSF KEAVSKGIGS THKILDPQGP FLQRWNKIFV
110 120 130 140 150
LACIIAVSLD PLFFYVPIID DAKKCLGIDK KMEITASVLR SFTDVFYVLH
160 170 180 190 200
IIFQFRTGFI APSSRVFGRG VLVEDKREIA KRYLSSHFII DILAVLPLPQ
210 220 230 240 250
MVILIIIPHM RGSSSLNTKN MLKFIVFFQY IPRFIRIYPL YKEVTRTSGI
260 270 280 290 300
LTETAWAGAA FNLFLYMLAS HVFGAFWYLF SIERETVCWK QACERNNPPC
310 320 330 340 350
ISKLLYCDPE TAGGNAFLNE SCPIQTPNTT LFDFGIFLDA LQSGVVESQD
360 370 380 390 400
FPQKFFYCFW WGLQNLSSLG QNLKTSTYIW EICFAVFISI AGLVLFSFLI
410 420 430 440 450
GNMQTYLQST TTRLEEMRVK RRDAEQWMSH RLLPENLRKR IRRYEQYKWQ
460 470 480 490 500
ETRGVDEENL LSNLPKDLRR DIKRHLCLAL LMRVPMFEKM DEQLLDALCD
510 520 530 540 550
RLQPVLYTEE SYIVREGDPV DEMLFIMRGK LLTITTNGGR TGFLNSEYLG
560 570 580 590 600
AGDFCGEELL TWALDPHSSS NLPISTRTVR ALMEVEAFAL KADDLKFVAS
610 620 630 640 650
QFRRLHSKQL RHTFRYYSQQ WKTWAACFIQ AAWRRYIKKK LEESLKEEEN
660 670 680 690 700
RLQDALAKEA CGSSPSLGAT IYASRFAANI LRTIRRSGSV RKPRMPERMP
710
PMLLQKPAEP DFNSDD
Length:716
Mass (Da):83,097
Last modified:August 1, 1998 - v1
Checksum:i5883CA949B6E7BF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16327 mRNA. Translation: CAA76178.1.
AB025622 Genomic DNA. Translation: BAB08416.1.
CP002688 Genomic DNA. Translation: AED96311.1.
AF370139 mRNA. Translation: AAK43954.1.
BT000991 mRNA. Translation: AAN41391.1.
PIRiT51354.
RefSeqiNP_200125.1. NM_124692.3.
UniGeneiAt.21042.
At.49166.

Genome annotation databases

EnsemblPlantsiAT5G53130.1; AT5G53130.1; AT5G53130.
GeneIDi835393.
GrameneiAT5G53130.1; AT5G53130.1; AT5G53130.
KEGGiath:AT5G53130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16327 mRNA. Translation: CAA76178.1.
AB025622 Genomic DNA. Translation: BAB08416.1.
CP002688 Genomic DNA. Translation: AED96311.1.
AF370139 mRNA. Translation: AAK43954.1.
BT000991 mRNA. Translation: AAN41391.1.
PIRiT51354.
RefSeqiNP_200125.1. NM_124692.3.
UniGeneiAt.21042.
At.49166.

3D structure databases

ProteinModelPortaliO65717.
SMRiO65717. Positions 420-604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20638. 4 interactions.
STRINGi3702.AT5G53130.1.

Protein family/group databases

TCDBi1.A.1.5.5. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiO65717.

Proteomic databases

PaxDbiO65717.
PRIDEiO65717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G53130.1; AT5G53130.1; AT5G53130.
GeneIDi835393.
GrameneiAT5G53130.1; AT5G53130.1; AT5G53130.
KEGGiath:AT5G53130.

Organism-specific databases

TAIRiAT5G53130.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO65717.
KOiK05391.
OMAiGQNMKTS.
OrthoDBiEOG09360404.
PhylomeDBiO65717.

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiO65717.

Gene expression databases

GenevisibleiO65717. AT.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGC1_ARATH
AccessioniPrimary (citable) accession number: O65717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.