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Protein

Cold shock protein 1

Gene

CSP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone that binds to RNA, single- (ssDNA) and double-stranded (dsDNA) DNA, and unwinds nucleic acid duplex. Exhibits a DNA melting activity. May be involved in cold resistance. Prevents seed germination under dehydration or salt stress conditions.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri100 – 11718CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 14918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18118CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 21518CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 24718CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27018CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 29718CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • double-stranded DNA binding Source: TAIR
  • RNA binding Source: TAIR
  • single-stranded DNA binding Source: TAIR
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cold acclimation Source: UniProtKB
  • DNA duplex unwinding Source: TAIR
  • regulation of transcription, DNA-templated Source: InterPro
  • response to cold Source: UniProtKB
  • response to salt stress Source: UniProtKB
  • response to water deprivation Source: UniProtKB
  • RNA secondary structure unwinding Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-72163. mRNA Splicing - Major Pathway.
R-ATH-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock protein 1
Short name:
AtCSP1
Alternative name(s):
Cold shock domain-containing protein 1
Gene namesi
Name:CSP1
Synonyms:CSDP1
Ordered Locus Names:At4g36020
ORF Names:T19K4.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G36020.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 299298Cold shock protein 1PRO_0000418158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO65639.
PRIDEiO65639.

PTM databases

iPTMnetiO65639.

Expressioni

Tissue specificityi

Mostly expressed in shoot apices and siliques, and, to a lower extent, in roots, cotyledons, stems, shoots, leaves, floral buds and flowers.1 Publication

Developmental stagei

High expression in the earliest stage of silique development, with a decrease during the middle stages of silique development and subsequently an increase during the later stages.1 Publication

Inductioni

Accumulates during cold acclimation, but down-regulated by dehydration and salt stresses.2 Publications

Gene expression databases

GenevisibleiO65639. AT.

Interactioni

Protein-protein interaction databases

BioGridi15040. 1 interaction.
STRINGi3702.AT4G36020.1.

Structurei

3D structure databases

ProteinModelPortaliO65639.
SMRiO65639. Positions 10-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7665CSDAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 277200Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the cold shock protein (CSP) family.Curated
Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CSD (cold-shock) domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri100 – 11718CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 14918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18118CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 21518CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 24718CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27018CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 29718CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN3J. Eukaryota.
KOG3070. Eukaryota.
COG1278. LUCA.
COG5082. LUCA.
HOGENOMiHOG000186262.
InParanoidiO65639.
KOiK09250.
OMAiRECPNMR.
OrthoDBiEOG09360SVB.
PhylomeDBiO65639.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 5 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 7 hits.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
PS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEDQSAAR STGKVNWFNA SKGYGFITPD DGSVELFVHQ SSIVSEGYRS
60 70 80 90 100
LTVGDAVEFA ITQGSDGKTK AVNVTAPGGG SLKKENNSRG NGARRGGGGS
110 120 130 140 150
GCYNCGELGH ISKDCGIGGG GGGGERRSRG GEGCYNCGDT GHFARDCTSA
160 170 180 190 200
GNGDQRGATK GGNDGCYTCG DVGHVARDCT QKSVGNGDQR GAVKGGNDGC
210 220 230 240 250
YTCGDVGHFA RDCTQKVAAG NVRSGGGGSG TCYSCGGVGH IARDCATKRQ
260 270 280 290
PSRGCYQCGG SGHLARDCDQ RGSGGGGNDN ACYKCGKEGH FARECSSVA
Length:299
Mass (Da):30,088
Last modified:August 1, 1998 - v1
Checksum:iB40DFCC8493F66F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022373 Genomic DNA. Translation: CAA18496.1.
AL161588 Genomic DNA. Translation: CAB81511.1.
CP002687 Genomic DNA. Translation: AEE86603.1.
AK226815 mRNA. Translation: BAE98911.1.
PIRiT05494.
RefSeqiNP_195326.1. NM_119769.3.
UniGeneiAt.23073.

Genome annotation databases

EnsemblPlantsiAT4G36020.1; AT4G36020.1; AT4G36020.
GeneIDi829758.
GrameneiAT4G36020.1; AT4G36020.1; AT4G36020.
KEGGiath:AT4G36020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022373 Genomic DNA. Translation: CAA18496.1.
AL161588 Genomic DNA. Translation: CAB81511.1.
CP002687 Genomic DNA. Translation: AEE86603.1.
AK226815 mRNA. Translation: BAE98911.1.
PIRiT05494.
RefSeqiNP_195326.1. NM_119769.3.
UniGeneiAt.23073.

3D structure databases

ProteinModelPortaliO65639.
SMRiO65639. Positions 10-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15040. 1 interaction.
STRINGi3702.AT4G36020.1.

PTM databases

iPTMnetiO65639.

Proteomic databases

PaxDbiO65639.
PRIDEiO65639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36020.1; AT4G36020.1; AT4G36020.
GeneIDi829758.
GrameneiAT4G36020.1; AT4G36020.1; AT4G36020.
KEGGiath:AT4G36020.

Organism-specific databases

TAIRiAT4G36020.

Phylogenomic databases

eggNOGiENOG410IN3J. Eukaryota.
KOG3070. Eukaryota.
COG1278. LUCA.
COG5082. LUCA.
HOGENOMiHOG000186262.
InParanoidiO65639.
KOiK09250.
OMAiRECPNMR.
OrthoDBiEOG09360SVB.
PhylomeDBiO65639.

Enzyme and pathway databases

ReactomeiR-ATH-72163. mRNA Splicing - Major Pathway.
R-ATH-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiO65639.

Gene expression databases

GenevisibleiO65639. AT.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 5 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 7 hits.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
PS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSP1_ARATH
AccessioniPrimary (citable) accession number: O65639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.