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Protein

Fructose-bisphosphate aldolase

Gene

M3E9.40

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI1 (At4g24620)), Glucose-6-phosphate isomerase 1, chloroplastic (PGI1), Glucose-6-phosphate isomerase (PGIC), Glucose-6-phosphate isomerase, cytosolic (PGIC)
  3. ATP-dependent 6-phosphofructokinase 1 (PFK1), ATP-dependent 6-phosphofructokinase 5, chloroplastic (PFK5), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha 1 (PFP-ALPHA1), ATP-dependent 6-phosphofructokinase 6 (PFK6), ATP-dependent 6-phosphofructokinase 3 (PFK3), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha 2 (PFP-ALPHA2), ATP-dependent 6-phosphofructokinase 4, chloroplastic (PFK4), ATP-dependent 6-phosphofructokinase 2 (PFK2), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 1 (PFP-BETA1), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 2 (PFP-BETA2), ATP-dependent 6-phosphofructokinase 7 (PFK7)
  4. Fructose-bisphosphate aldolase (M3E9.40), Fructose-bisphosphate aldolase (F17C15_110), Fructose-bisphosphate aldolase (At2g36460), Fructose-bisphosphate aldolase (FBA1), Fructose-bisphosphate aldolase (FBA1), Fructose-bisphosphate aldolase (FBA2), Probable fructose-bisphosphate aldolase 1, chloroplastic (FBA1), Fructose-bisphosphate aldolase (F8J2_100), Fructose-bisphosphate aldolase (F17C15.11), Fructose-bisphosphate aldolase, cytoplasmic isozyme (At4g26520), Probable fructose-bisphosphate aldolase 3, chloroplastic (FBA3), Fructose-bisphosphate aldolase (At2g36460), Probable fructose-bisphosphate aldolase 2, chloroplastic (FBA2), Fructose-bisphosphate aldolase (At5g03690), Fructose-bisphosphate aldolase (At2g21330), Fructose-bisphosphate aldolase (At5g03690)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

  • fructose-bisphosphate aldolase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciARA:AT4G26530-MONOMER.
ARA:GQT-1888-MONOMER.
ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-70171. Glycolysis.
R-ATH-70263. Gluconeogenesis.
R-ATH-70350. Fructose catabolism.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolaseUniRule annotationSAAS annotation (EC:4.1.2.13UniRule annotationSAAS annotation)
Gene namesi
Name:M3E9.40Imported
Ordered Locus Names:At4g26530Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G26530.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
Complete GO annotation...

PTM / Processingi

Proteomic databases

ProMEXiO65581.

Interactioni

Protein-protein interaction databases

IntActiO65581. 2 interactions.
STRINGi3702.AT4G26530.1.

Structurei

3D structure databases

SMRiO65581. Positions 9-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
HOGENOMiHOG000220876.
KOiK01623.
OMAiPNMVIDG.
PhylomeDBiO65581.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFVGKYAD ELIKTAKYIA TPGKGILAAD ESTGTIGKRF ASINVENIES
60 70 80 90 100
NRQALRELLF TSPGTFPCLS GVILFEETLY QKTTDGKPFV ELLMENGVIP
110 120 130 140 150
GIKVDKGVVD LAGTNGETTT QGLDSLGARC QEYYKAGARF AKWRAVLKIG
160 170 180 190 200
ATEPSELSIQ ENAKGLARYA IICQENGLVP IVEPEVLTDG SHDIKKCAAV
210 220 230 240 250
TETVLAAVYK ALNDHHVLLE GTLLKPNMVT PGSDSPKVAP EVIAEYTVTA
260 270 280 290 300
LRRTVPPAVP GIVFLSGGQS EEEATLNLNA MNKLDVLKPW TLTFSFGRAL
310 320 330 340 350
QQSTLKAWAG KTENVAKAQA TFLTRCKGNS DATLGKYTGG ASGDSAASES

LYEEGYKY
Length:358
Mass (Da):38,294
Last modified:August 1, 1998 - v1
Checksum:i351B4420956E64C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY087376 mRNA. Translation: AAM64926.1.
BT002006 mRNA. Translation: AAN72017.1.
BT008844 mRNA. Translation: AAP68283.1.
CP002687 Genomic DNA. Translation: AEE85214.1.
CP002687 Genomic DNA. Translation: AEE85215.1.
AL022223 Genomic DNA. Translation: CAA18217.1.
AL161565 Genomic DNA. Translation: CAB79508.1.
PIRiT05051.
RefSeqiNP_001031721.1. NM_001036644.2.
NP_194383.1. NM_118786.3.
UniGeneiAt.57980.

Genome annotation databases

EnsemblPlantsiAT4G26530.1; AT4G26530.1; AT4G26530.
AT4G26530.2; AT4G26530.2; AT4G26530.
GeneIDi828759.
GrameneiAT4G26530.1; AT4G26530.1; AT4G26530.
AT4G26530.2; AT4G26530.2; AT4G26530.
KEGGiath:AT4G26530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY087376 mRNA. Translation: AAM64926.1.
BT002006 mRNA. Translation: AAN72017.1.
BT008844 mRNA. Translation: AAP68283.1.
CP002687 Genomic DNA. Translation: AEE85214.1.
CP002687 Genomic DNA. Translation: AEE85215.1.
AL022223 Genomic DNA. Translation: CAA18217.1.
AL161565 Genomic DNA. Translation: CAB79508.1.
PIRiT05051.
RefSeqiNP_001031721.1. NM_001036644.2.
NP_194383.1. NM_118786.3.
UniGeneiAt.57980.

3D structure databases

SMRiO65581. Positions 9-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO65581. 2 interactions.
STRINGi3702.AT4G26530.1.

Proteomic databases

ProMEXiO65581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G26530.1; AT4G26530.1; AT4G26530.
AT4G26530.2; AT4G26530.2; AT4G26530.
GeneIDi828759.
GrameneiAT4G26530.1; AT4G26530.1; AT4G26530.
AT4G26530.2; AT4G26530.2; AT4G26530.
KEGGiath:AT4G26530.

Organism-specific databases

TAIRiAT4G26530.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
HOGENOMiHOG000220876.
KOiK01623.
OMAiPNMVIDG.
PhylomeDBiO65581.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BioCyciARA:AT4G26530-MONOMER.
ARA:GQT-1888-MONOMER.
ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-70171. Glycolysis.
R-ATH-70263. Gluconeogenesis.
R-ATH-70350. Fructose catabolism.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Bevan M., Vandenbol M., Jallet C., Portetelle D., Hoheisel J., Mewes H.W., Mayer K.F.X., Lemcke K., Schueller C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    EU, CSHL and WU Arabidopsis Sequencing Project
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. ColumbiaImported.
  3. EU Arabidopsis sequencing project
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Zimmermann W., Grueneisen A., Wambutt R., Kalicki J., Wohldmann P., Smith A., Mewes H.W., Lemcke K., Mayer K.F.X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. EU Arabidopsis sequencing project
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Vandenbol M., Jallet C., Portetelle D., Mewes H.W., Lemcke K., Mayer K.F.X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Full-length messenger RNA sequences greatly improve genome annotation."
    Haas B.J., Volfovsky N., Town C.D., Troukhan M., Alexandrov N., Feldmann K.A., Flavell R.B., White O., Salzberg S.L.
    Genome Biol. 3:RESEARCH0029-RESEARCH0029(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Brover V., Troukhan M., Alexandrov N., Lu Y.-P., Flavell R., Feldmann K.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Cited for: NUCLEOTIDE SEQUENCE.
  10. Cited for: NUCLEOTIDE SEQUENCE.
  11. "Features of Arabidopsis genes and genome discovered using full-length cDNAs."
    Alexandrov N.A., Troukhan M.E., Brover V.V., Flavell R.B., Feldmann K.A.
    Plant Mol. Biol. 60:71-87(2006)
    Cited for: NUCLEOTIDE SEQUENCE.
  12. TAIR10
    Swarbreck D., Lamesch P., Wilks C., Huala E.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. ColumbiaImported.

Entry informationi

Entry nameiO65581_ARATH
AccessioniPrimary (citable) accession number: O65581
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.