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Protein

Aminomethyltransferase, mitochondrial

Gene

GDCST

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine.By similarity

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei235SubstrateBy similarity1
Binding sitei266SubstrateBy similarity1
Binding sitei404SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • glycine catabolic process Source: InterPro
  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

ReactomeiR-ATH-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Aminomethyltransferase, mitochondrial (EC:2.1.2.10)
Alternative name(s):
Glycine cleavage system T protein
Short name:
GCVT
Gene namesi
Name:GDCST
Synonyms:GDT1
Ordered Locus Names:At1g11860
ORF Names:F12F1.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G11860
TAIRilocus:2008900 AT1G11860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000001075825 – 408Aminomethyltransferase, mitochondrialAdd BLAST384

Proteomic databases

PaxDbiO65396
PRIDEiO65396

2D gel databases

SWISS-2DPAGEiO65396

PTM databases

iPTMnetiO65396

Expressioni

Gene expression databases

ExpressionAtlasiO65396 baseline and differential
GenevisibleiO65396 AT

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.

Protein-protein interaction databases

BioGridi22973, 2 interactors
STRINGi3702.AT1G11860.1

Structurei

3D structure databases

ProteinModelPortaliO65396
SMRiO65396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2770 Eukaryota
COG0404 LUCA
HOGENOMiHOG000239380
InParanoidiO65396
KOiK00605
OMAiMPVQYPA
OrthoDBiEOG09360A95
PhylomeDBiO65396

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
InterProiView protein in InterPro
IPR006223 GCS_T
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O65396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGSLWQLG QSITRRLAQS DKKVVSRRYF ASEADLKKTA LYDFHVAHGG
60 70 80 90 100
KMVPFAGWSM PIQYKDSIMD STVNCRENGS LFDVAHMCGL SLKGKDCVPF
110 120 130 140 150
LETLVVADVA GLAPGTGSLT VFTNEKGGAI DDSVITKVTD EHIYLVVNAG
160 170 180 190 200
CRDKDLAHIE EHMKAFKSKG GDVSWHIHDE RSLLALQGPL AAPVLQHLTK
210 220 230 240 250
EDLSKLYFGN FQILDINGST CFLTRTGYTG EDGFEISVPD EHAVDLAKAI
260 270 280 290 300
LEKSEGKVRL TGLGARDSLR LEAGLCLYGN DMEQHISPVE AGLTWAIGKR
310 320 330 340 350
RRAEGGFLGA DVILQQLKDG PTIRRVGFFS SGPPARSHSE VHDESGNKIG
360 370 380 390 400
EITSGGFSPN LKKNIAMGYV KSGQHKTGTK VKILVRGKPY EGSITKMPFV

ATKYYKPT
Length:408
Mass (Da):44,445
Last modified:August 1, 1998 - v1
Checksum:i93B909768912736B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002131 Genomic DNA Translation: AAC17627.1
CP002684 Genomic DNA Translation: AEE28802.1
CP002684 Genomic DNA Translation: AEE28803.1
AY125509 mRNA Translation: AAM78101.1
BT006361 mRNA Translation: AAP21169.1
Z26545 mRNA Translation: CAA81316.1
PIRiH86252
RefSeqiNP_172650.1, NM_101057.5
NP_849646.1, NM_179315.1
UniGeneiAt.47506

Genome annotation databases

EnsemblPlantsiAT1G11860.1; AT1G11860.1; AT1G11860
AT1G11860.2; AT1G11860.2; AT1G11860
GeneIDi837733
GrameneiAT1G11860.1; AT1G11860.1; AT1G11860
AT1G11860.2; AT1G11860.2; AT1G11860
KEGGiath:AT1G11860

Similar proteinsi

Entry informationi

Entry nameiGCST_ARATH
AccessioniPrimary (citable) accession number: O65396
Secondary accession number(s): Q42123
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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