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Protein

Syntaxin-41

Gene

SYP41

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the secretory pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-6811438. Intra-Golgi traffic.
R-ATH-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-41
Short name:
AtSYP41
Short name:
AtTLG2a
Gene namesi
Name:SYP41
Ordered Locus Names:At5g26980
ORF Names:F2P16.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G26980.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 301301CytoplasmicSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • SNARE complex Source: GO_Central
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Syntaxin-41PRO_0000210258Add
BLAST

Proteomic databases

PaxDbiO65359.
PRIDEiO65359.

Expressioni

Gene expression databases

GenevisibleiO65359. AT.

Interactioni

Subunit structurei

Interacts with VTI12 and SYP61 to form a t-SNARE complex and with VPS45.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS45O490486EBI-1750331,EBI-1750377

GO - Molecular functioni

Protein-protein interaction databases

BioGridi18031. 29 interactions.
IntActiO65359. 25 interactions.
STRINGi3702.AT5G26980.1.

Structurei

3D structure databases

ProteinModelPortaliO65359.
SMRiO65359. Positions 217-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini226 – 28863t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 14631Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000190358.
InParanoidiO65359.
KOiK08489.
OMAiKPRYIGP.
PhylomeDBiO65359.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O65359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRNRTLLF RKYRNSLRSV RAPLSSSSLT GTRSGGVGPV IEMASTSLLN
60 70 80 90 100
PNRSYAPIST EDPGTSSKGA ITVGLPPAWV DVSEEISVNI QRARTKMAEL
110 120 130 140 150
GKAHAKALMP SFGDGKEDQH NIESLTQEIT FLLKKSEKQL QRLSASGPSE
160 170 180 190 200
DSNVRKNVQR SLATDLQLLS MELRKKQSTY LKRLRQQKED GMDLEMNLSR
210 220 230 240 250
NRYRPEEDDF GDMLNEHQMS KIKKSEEVSV EREKEIQQVV ESVNDLAQIM
260 270 280 290 300
KDLSALVIDQ GTIVDRIDYN IENVATTVED GLKQLQKAER TQRHGGMVKC
310 320
ASVLVILCFI MLLLLILKEI FL
Length:322
Mass (Da):36,134
Last modified:August 1, 1998 - v1
Checksum:iC7314E34BA0DD8E9
GO

Sequence cautioni

The sequence AAB61065.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067789 mRNA. Translation: AAC27707.1.
AF007270 Genomic DNA. Translation: AAB61065.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93636.1.
CP002688 Genomic DNA. Translation: AED93637.1.
RefSeqiNP_001031950.1. NM_001036873.1.
NP_198050.1. NM_122580.3.
UniGeneiAt.24148.

Genome annotation databases

EnsemblPlantsiAT5G26980.1; AT5G26980.1; AT5G26980.
AT5G26980.2; AT5G26980.2; AT5G26980.
GeneIDi832756.
GrameneiAT5G26980.1; AT5G26980.1; AT5G26980.
AT5G26980.2; AT5G26980.2; AT5G26980.
KEGGiath:AT5G26980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067789 mRNA. Translation: AAC27707.1.
AF007270 Genomic DNA. Translation: AAB61065.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93636.1.
CP002688 Genomic DNA. Translation: AED93637.1.
RefSeqiNP_001031950.1. NM_001036873.1.
NP_198050.1. NM_122580.3.
UniGeneiAt.24148.

3D structure databases

ProteinModelPortaliO65359.
SMRiO65359. Positions 217-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi18031. 29 interactions.
IntActiO65359. 25 interactions.
STRINGi3702.AT5G26980.1.

Proteomic databases

PaxDbiO65359.
PRIDEiO65359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G26980.1; AT5G26980.1; AT5G26980.
AT5G26980.2; AT5G26980.2; AT5G26980.
GeneIDi832756.
GrameneiAT5G26980.1; AT5G26980.1; AT5G26980.
AT5G26980.2; AT5G26980.2; AT5G26980.
KEGGiath:AT5G26980.

Organism-specific databases

TAIRiAT5G26980.

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000190358.
InParanoidiO65359.
KOiK08489.
OMAiKPRYIGP.
PhylomeDBiO65359.

Enzyme and pathway databases

ReactomeiR-ATH-6811438. Intra-Golgi traffic.
R-ATH-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiO65359.

Gene expression databases

GenevisibleiO65359. AT.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE, INTERACTION WITH VPS45 AND VTI12.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Interactions between syntaxins identify at least five SNARE complexes within the Golgi/prevacuolar system of the Arabidopsis cell."
    Sanderfoot A.A., Kovaleva V., Bassham D.C., Raikhel N.V.
    Mol. Biol. Cell 12:3733-3743(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VTI12 AND SYP61.

Entry informationi

Entry nameiSYP41_ARATH
AccessioniPrimary (citable) accession number: O65359
Secondary accession number(s): O04639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.