SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O64948

- LONP2_ARATH

UniProt

O64948 - LONP2_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lon protease homolog 2, peroxisomal
Gene
LON2, At5g47040, MQD22.18
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix By similarity. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei783 – 7831 By similarity
Active sitei826 – 8261 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi408 – 4158ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: RefGenome
  2. ATP-dependent peptidase activity Source: RefGenome
  3. sequence-specific DNA binding Source: RefGenome
  4. serine-type endopeptidase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: RefGenome
  2. growth Source: TAIR
  3. lateral root development Source: TAIR
  4. misfolded or incompletely synthesized protein catabolic process Source: RefGenome
  5. protein import into peroxisome matrix, docking Source: TAIR
  6. protein processing Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G47040-MONOMER.

Protein family/group databases

MEROPSiS16.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 2, peroxisomal (EC:3.4.21.-)
Gene namesi
Name:LON2
Ordered Locus Names:At5g47040
ORF Names:MQD22.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G47040.

Subcellular locationi

Peroxisome matrix By similarity 1 Publication

GO - Cellular componenti

  1. nucleoid Source: RefGenome
  2. organelle lumen Source: TAIR
  3. peroxisomal matrix Source: RefGenome
  4. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 888888Lon protease homolog 2, peroxisomalUniRule annotation
PRO_0000026736Add
BLAST

Proteomic databases

PaxDbiO64948.
PRIDEiO64948.

Expressioni

Gene expression databases

GenevestigatoriO64948.

Interactioni

Protein-protein interaction databases

BioGridi19998. 1 interaction.
STRINGi3702.AT5G47040.1-P.

Structurei

3D structure databases

ProteinModelPortaliO64948.
SMRiO64948. Positions 93-296, 301-876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 253243Lon
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi886 – 8883Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Belongs to the peptidase S16 family.
Contains 1 Lon domain.

Phylogenomic databases

eggNOGiCOG0466.
HOGENOMiHOG000261408.
InParanoidiO64948.
KOiK01338.
OMAiSHIWEAI.
PhylomeDBiO64948.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03121. lonp2_euk.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027501. Lonp2_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 2 hits.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O64948-1 [UniParc]FASTAAdd to Basket

« Hide

MAETVELPSR LAILPFRNKV LLPGAIIRIR CTSHSSVTLV EQELWQKEEK    50
GLIGILPVRD DAEGSSIGTM INPGAGSDSG ERSLKFLVGT TDAQKSDAKD 100
QQDLQWHTRG VAARALHLSR GVEKPSGRVT YVVVLEGLSR FNVQELGKRG 150
PYSVARITSL EMTKAELEQV KQDPDFVALS RQFKTTAMEL VSVLEQKQKT 200
GGRTKVLLET VPIHKLADIF VASFEMSFEE QLSMLDSVDL KVRLSKATEL 250
VDRHLQSIRV AEKITQKVEG QLSKSQKEYL LRQQMRAIKE ELGDNDDDED 300
DVAALERKMQ AAGMPSNIWK HAQRELRRLK KMQPQQPGYN SSRVYLELLA 350
DLPWDKASEE HELDLKAAKE RLDSDHYGLA KVKQRIIEYL AVRKLKPDAR 400
GPVLCFVGPP GVGKTSLASS IAAALGRKFV RLSLGGVKDE ADIRGHRRTY 450
IGSMPGRLID GLKRVGVCNP VMLLDEIDKT GSDVRGDPAS ALLEVLDPEQ 500
NKSFNDHYLN VPYDLSKVVF VATANRVQPI PPPLLDRMEL IELPGYTQEE 550
KLKIAMRHLI PRVLDQHGLS SEFLKIPEAM VKNIIQRYTR EAGVRSLERN 600
LAALARAAAV MVAEHEQSLP LSKDVQKLTS PLLNGRMAEG GEVEMEVIPM 650
GVNDHEIGGT FQSPSALVVD ETMLEKILGP PRFDDSEAAD RVASAGVSVG 700
LVWTTFGGEV QFVEATSMVG KGEMHLTGQL GDVIKESAQL ALTWVRARAS 750
DFKLALAGDM NVLDGRDIHI HFPAGAVPKD GPSAGVTLVT ALVSLFSQKR 800
VRADTAMTGE MTLRGLVLPV GGIKDKILAA HRYGIKRVIL PQRNSKDLVE 850
VPAAVLSSLE VILAKRMEDV LENAFEGGCP WRNNYSKL 888
Length:888
Mass (Da):97,862
Last modified:August 1, 1998 - v1
Checksum:iD7BAE741926A6F2F
GO

Sequence cautioni

The sequence AAO00734.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF033862 Genomic DNA. Translation: AAC05085.1.
AB013394 Genomic DNA. Translation: BAB10243.1.
CP002688 Genomic DNA. Translation: AED95460.1.
BT002374 mRNA. Translation: AAO00734.1. Different initiation.
BT010392 mRNA. Translation: AAQ56835.1.
RefSeqiNP_568675.1. NM_124075.3.
UniGeneiAt.8585.

Genome annotation databases

EnsemblPlantsiAT5G47040.1; AT5G47040.1; AT5G47040.
GeneIDi834750.
KEGGiath:AT5G47040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF033862 Genomic DNA. Translation: AAC05085.1 .
AB013394 Genomic DNA. Translation: BAB10243.1 .
CP002688 Genomic DNA. Translation: AED95460.1 .
BT002374 mRNA. Translation: AAO00734.1 . Different initiation.
BT010392 mRNA. Translation: AAQ56835.1 .
RefSeqi NP_568675.1. NM_124075.3.
UniGenei At.8585.

3D structure databases

ProteinModelPortali O64948.
SMRi O64948. Positions 93-296, 301-876.
ModBasei Search...

Protein-protein interaction databases

BioGridi 19998. 1 interaction.
STRINGi 3702.AT5G47040.1-P.

Protein family/group databases

MEROPSi S16.003.

Proteomic databases

PaxDbi O64948.
PRIDEi O64948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G47040.1 ; AT5G47040.1 ; AT5G47040 .
GeneIDi 834750.
KEGGi ath:AT5G47040.

Organism-specific databases

GeneFarmi 1773. 137.
TAIRi AT5G47040.

Phylogenomic databases

eggNOGi COG0466.
HOGENOMi HOG000261408.
InParanoidi O64948.
KOi K01338.
OMAi SHIWEAI.
PhylomeDBi O64948.

Enzyme and pathway databases

BioCyci ARA:AT5G47040-MONOMER.

Miscellaneous databases

PROi O64948.

Gene expression databases

Genevestigatori O64948.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_03121. lonp2_euk.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027501. Lonp2_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10046. PTHR10046. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001174. Lon_proteas. 1 hit.
SMARTi SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 2 hits.
TIGRFAMsi TIGR00763. lon. 1 hit.
PROSITEi PS01046. LON_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence analysis of a genomic clone of Arabidopsis thaliana encoding a LON protein."
    Murray C., Christeller J.T., Gatehouse L.N., Laing W.A.
    Plant Gene Register PGR98-023
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Landsberg erecta.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 317-888.
    Strain: cv. Columbia.
  5. "In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes."
    Reumann S., Quan S., Aung K., Yang P., Manandhar-Shrestha K., Holbrook D., Linka N., Switzenberg R., Wilkerson C.G., Weber A.P., Olsen L.J., Hu J.
    Plant Physiol. 150:125-143(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Arabidopsis LON2 is necessary for peroxisomal function and sustained matrix protein import."
    Lingard M.J., Bartel B.
    Plant Physiol. 151:1354-1365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLONP2_ARATH
AccessioniPrimary (citable) accession number: O64948
Secondary accession number(s): Q8GT60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi