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Protein

Polcalcin Jun o 2

Gene
N/A
Organism
Juniperus oxycedrus (Prickly juniper)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi35 – 46121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi71 – 82122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi104 – 115123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi140 – 151124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polcalcin Jun o 2
Alternative name(s):
Calcium-binding pollen allergen Jun o 2
Allergen: Jun o 2
OrganismiJuniperus oxycedrus (Prickly juniper)
Taxonomic identifieri69008 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaeCupressalesCupressaceaeJuniperus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3341. Jun o 4.0101.
430. Jun o 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Polcalcin Jun o 2PRO_0000073673Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO64943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini58 – 9134EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini91 – 12636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O64943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEVPSSDGS KSACSGEVVM EQSVHELEEV FKKFDANGDG KISGSELADI
60 70 80 90 100
LRSLGSDVGE AEVKAMMEEA DADGDGYVSL QEFVDLNNKG ASVKDLKNAF
110 120 130 140 150
KVFDRDCNGS ISAAELCHTL ESVGEPCTIE ESKNIIHNVD KNGDGLISVE
160
EFQTMMTSEM TDKSK
Length:165
Mass (Da):17,753
Last modified:November 1, 1999 - v2
Checksum:i69639729E99E8D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031471 mRNA. Translation: AAC15474.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031471 mRNA. Translation: AAC15474.2.

3D structure databases

ProteinModelPortaliO64943.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3341. Jun o 4.0101.
430. Jun o 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of a cross-reactive Juniperus oxycedrus pollen allergen, Jun o 2: a novel calcium-binding allergen."
    Tinghino R., Barletta B., Palumbo S., Afferni C., Iacovacci P., Mari A., Di Felice G., Pini C.
    J. Allergy Clin. Immunol. 101:772-777(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.

Entry informationi

Entry nameiPOLC2_JUNOX
AccessioniPrimary (citable) accession number: O64943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: December 9, 2015
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.