Reviewed, UniProtKB/Swiss-Prot O64905 (FPPS_HELAN)

Names and origin

Protein names

Recommended name:
    Farnesyl pyrophosphate synthetase
      Short name=FPP synthetase
      Short name=FPS
Alternative name(s):
    Farnesyl diphosphate synthetase
Including the following 2 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10

Gene names

Name:	FPS1
Synonyms:	FRP

Organism

Helianthus annuus (Common sunflower)

Taxonomic identifier

4232 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Helianthus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Farnesyl pyrophosphate synthetase		PRO_0000123955

Sequences

	Sequence		Length	Mass (Da)
	O64905-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D2EE3FB9B5912468	FASTA	341	39,061
	10 20 30 40 50 60 MASDLKSKFL HVYQTLKSEL LNDPAFEFHH DSRQWIDKML DYNVPGGKLN RGLSVVDSYQ 70 80 90 100 110 120 LLKGAELTDD EIFLASALGW CIEWLQAYFL VLDDIMDGSH TRRGQPCWFR LPKVGMIAAN 130 140 150 160 170 180 DGLILRNHVP RILKKHFRGK PYYVDLVDLF NEVEFQTASG QMIDLITTLV GEKDLSKYSL 190 200 210 220 230 240 SIHRRIVQYK TAYYSFYLPV ACALLMFGED LDNHVEVKNV LVEMGTYFQV QDDYLDCFGA 250 260 270 280 290 300 PEVIGKIGTD IEDFSSWLVV KALELANEEQ KKVLHENYGK KDPSSVAKVK ELYNTLNLQG 310 320 330 340 VFEDYESTSY KKLITSIEGH PSKAVQAVLK SFLGKIYKRQ K

References

[1]	Park S.C., Kim Y.S., Oh S.K., Shin D.H., Chung C.H., Han K.H., Kang H.S., Cho J.W. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF019892 mRNA. Translation: AAC78557.1.
3D structure databases
HSSP	HSSP built from PDB template 1UBY based on UniProtKB P08836.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.1. 1739. 2.5.1.10. 1739.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FPPS_HELAN

Accession

Primary (citable) accession number: O64905

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)