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O64905 (FPPS_HELAN) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Farnesyl pyrophosphate synthase
Short name=FPP synthase
Short name=FPS
EC=2.5.1.10
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene names
Name:FPS1
Synonyms:FRP
OrganismHelianthus annuus (Common sunflower)
Taxonomic identifier4232 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Helianthus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Farnesyl pyrophosphate synthase
PRO_0000123955

Sites

Metal binding931Magnesium 1 By similarity
Metal binding931Magnesium 2 By similarity
Metal binding971Magnesium 1 By similarity
Metal binding971Magnesium 2 By similarity
Metal binding2321Magnesium 3 By similarity
Binding site481Isopentenyl diphosphate By similarity
Binding site511Isopentenyl diphosphate By similarity
Binding site861Isopentenyl diphosphate By similarity
Binding site1021Dimethylallyl diphosphate By similarity
Binding site1031Isopentenyl diphosphate By similarity
Binding site1901Dimethylallyl diphosphate By similarity
Binding site1911Dimethylallyl diphosphate By similarity
Binding site2291Dimethylallyl diphosphate By similarity
Binding site2461Dimethylallyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
O64905 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D2EE3FB9B5912468

FASTA34139,061
        10         20         30         40         50         60 
MASDLKSKFL HVYQTLKSEL LNDPAFEFHH DSRQWIDKML DYNVPGGKLN RGLSVVDSYQ 

        70         80         90        100        110        120 
LLKGAELTDD EIFLASALGW CIEWLQAYFL VLDDIMDGSH TRRGQPCWFR LPKVGMIAAN 

       130        140        150        160        170        180 
DGLILRNHVP RILKKHFRGK PYYVDLVDLF NEVEFQTASG QMIDLITTLV GEKDLSKYSL 

       190        200        210        220        230        240 
SIHRRIVQYK TAYYSFYLPV ACALLMFGED LDNHVEVKNV LVEMGTYFQV QDDYLDCFGA 

       250        260        270        280        290        300 
PEVIGKIGTD IEDFSSWLVV KALELANEEQ KKVLHENYGK KDPSSVAKVK ELYNTLNLQG 

       310        320        330        340 
VFEDYESTSY KKLITSIEGH PSKAVQAVLK SFLGKIYKRQ K

« Hide

References

[1]Park S.C., Kim Y.S., Oh S.K., Shin D.H., Chung C.H., Han K.H., Kang H.S., Cho J.W.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF019892 mRNA. Translation: AAC78557.1.

3D structure databases

ProteinModelPortalO64905.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFPPS_HELAN
AccessionPrimary (citable) accession number: O64905
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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