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O64889

- GUN12_ARATH

UniProt

O64889 - GUN12_ARATH

Protein

Endoglucanase 12

Gene

At2g44540

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131PROSITE-ProRule annotation
    Active sitei465 – 4651PROSITE-ProRule annotation
    Active sitei474 – 4741PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciARA:AT2G44540-MONOMER.

    Protein family/group databases

    CAZyiGH9. Glycoside Hydrolase Family 9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase 12 (EC:3.2.1.4)
    Alternative name(s):
    Endo-1,4-beta glucanase 12
    Gene namesi
    Ordered Locus Names:At2g44540
    ORF Names:F4I1.52
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G44540.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 491460Endoglucanase 12PRO_0000249264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO64889.
    PRIDEiO64889.

    Expressioni

    Gene expression databases

    GenevestigatoriO64889.

    Interactioni

    Protein-protein interaction databases

    IntActiO64889. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO64889.
    SMRiO64889. Positions 33-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG05134.
    HOGENOMiHOG000021033.
    InParanoidiO64889.
    OMAiSNIAYIC.
    PhylomeDBiO64889.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR001701. Glyco_hydro_9.
    IPR018221. Glyco_hydro_9_AS.
    [Graphical view]
    PfamiPF00759. Glyco_hydro_9. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 1 hit.
    PROSITEiPS00592. GLYCOSYL_HYDROL_F9_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O64889-1 [UniParc]FASTAAdd to Basket

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    MSQSKNGSSQ CLWTSICIVV LVMSMARGAV STNYAEALQK SLLYFEAQRS    50
    GKLPPNQKVT WRGDSALKDG SDAHIDLTGG YYDAGDNMKF GFPLAFTTTM 100
    LAWSNIEMGS ELRAHHEQGN SLRALKWATD YLIKAHPQPN VLYGQVGEGN 150
    SDHKCWMRPE DMTTPRTSYR IDAQHPGSDL AGETAAAMAA ASIAFAPFDK 200
    AYANILIGHA KDLFAFAKAH PGLYQNSITN AGGFYASSGY EDELLWAAAW 250
    LHRATNDQIY LNYLTQASGT GGPRSVFAWD DKFVGAQVLM AKLALERKVG 300
    SNGKIAEYKS MAEQFICNCA QKGSNNVKKT PGGLLYFLPW NNLQYTTTAS 350
    FVLSAYSKYL TKAKASIQCP KGALQASDLL QIARSQVDYI LGSNPQKMSY 400
    MVGVGTNYPK KPHHRAASIV SIRKDKTPVT CSGGYDKWYN NPAPNPNVLM 450
    GALVGGPNEN DVYGDERSNF QQAEPATVTV APFVGVLAAV F 491
    Length:491
    Mass (Da):53,421
    Last modified:August 1, 1998 - v1
    Checksum:iE8C02220EA89635B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC003672 Genomic DNA. Translation: AAC27456.1.
    AC004521 Genomic DNA. Translation: AAM14965.1.
    CP002685 Genomic DNA. Translation: AEC10436.1.
    PIRiT02410.
    RefSeqiNP_181982.1. NM_130018.2.
    UniGeneiAt.12528.

    Genome annotation databases

    EnsemblPlantsiAT2G44540.1; AT2G44540.1; AT2G44540.
    GeneIDi819062.
    KEGGiath:AT2G44540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC003672 Genomic DNA. Translation: AAC27456.1 .
    AC004521 Genomic DNA. Translation: AAM14965.1 .
    CP002685 Genomic DNA. Translation: AEC10436.1 .
    PIRi T02410.
    RefSeqi NP_181982.1. NM_130018.2.
    UniGenei At.12528.

    3D structure databases

    ProteinModelPortali O64889.
    SMRi O64889. Positions 33-488.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O64889. 1 interaction.

    Protein family/group databases

    CAZyi GH9. Glycoside Hydrolase Family 9.

    Proteomic databases

    PaxDbi O64889.
    PRIDEi O64889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G44540.1 ; AT2G44540.1 ; AT2G44540 .
    GeneIDi 819062.
    KEGGi ath:AT2G44540.

    Organism-specific databases

    TAIRi AT2G44540.

    Phylogenomic databases

    eggNOGi NOG05134.
    HOGENOMi HOG000021033.
    InParanoidi O64889.
    OMAi SNIAYIC.
    PhylomeDBi O64889.

    Enzyme and pathway databases

    BioCyci ARA:AT2G44540-MONOMER.

    Gene expression databases

    Genevestigatori O64889.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR001701. Glyco_hydro_9.
    IPR018221. Glyco_hydro_9_AS.
    [Graphical view ]
    Pfami PF00759. Glyco_hydro_9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 1 hit.
    PROSITEi PS00592. GLYCOSYL_HYDROL_F9_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Phylogenetic analysis of the plant endo-beta-1,4-glucanase gene family."
      Libertini E., Li Y., McQueen-Mason S.J.
      J. Mol. Evol. 58:506-515(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiGUN12_ARATH
    AccessioniPrimary (citable) accession number: O64889
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3