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Protein

Ribose-phosphate pyrophosphokinase 5, chloroplastic

Gene

PRS5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi202MagnesiumSequence analysis1
Metal bindingi204MagnesiumSequence analysis1
Metal bindingi213MagnesiumSequence analysis1
Metal bindingi217MagnesiumSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G44530-MONOMER.
ReactomeiR-ATH-73843. 5-Phosphoribose 1-diphosphate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinase 5, chloroplastic (EC:2.7.6.1)
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 5
Gene namesi
Name:PRS5
Ordered Locus Names:At2g44530
ORF Names:F16B22.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G44530.
TAIRilocus:2042351. AT2G44530.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: UniProtKB-SubCell
  • plastid Source: TAIR

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33ChloroplastSequence analysisAdd BLAST33
ChainiPRO_000014109634 – 394Ribose-phosphate pyrophosphokinase 5, chloroplasticAdd BLAST361

Proteomic databases

PaxDbiO64888.
PRIDEiO64888.

PTM databases

iPTMnetiO64888.

Expressioni

Gene expression databases

ExpressionAtlasiO64888. baseline and differential.
GenevisibleiO64888. AT.

Interactioni

Protein-protein interaction databases

BioGridi4397. 1 interactor.
IntActiO64888. 1 interactor.
STRINGi3702.AT2G44530.1.

Structurei

3D structure databases

ProteinModelPortaliO64888.
SMRiO64888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni288 – 303Binding of phosphoribosylpyrophosphateSequence analysisAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1448. Eukaryota.
COG0462. LUCA.
HOGENOMiHOG000210449.
InParanoidiO64888.
KOiK00948.
OMAiTTHDYEN.
OrthoDBiEOG09360FWX.
PhylomeDBiO64888.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_00583_B. RibP_PPkinase_B. 1 hit.
InterProiView protein in InterPro
IPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
PfamiView protein in Pfam
PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiView protein in PROSITE
PS00114. PRPP_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O64888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASIVQPSPT FPALNLRRSS LIRPPSSVRF PLKCNAADPY KFDGGNSAGF
60 70 80 90 100
HLLTGDTVPA SFSRTRLEDS IYQNTTRLRI FSGTANPILA QEISCYLGLD
110 120 130 140 150
LGKIKIKRFA DGEIYVQLQE SVRGCDVFLV QPTCPPANEN LMELLVMIDA
160 170 180 190 200
CRRASAKTIT AVIPYFGYAR ADRKTQGRES IAAKLVANLI TQSGADRVLA
210 220 230 240 250
CDLHSGQSMG YFDIPVDHVY GQPVILDYLA SKAISSEDLV VVSPDVGGVA
260 270 280 290 300
RARAFAKKLS DAPLAIVDKR RHGHNVAEVM NLIGDVKGKV AIMVDDMIDT
310 320 330 340 350
AGTISKGAAL LHQEGAREVY ACTTHAVFSP PAISRLSSGL FQEVIITNTI
360 370 380 390
PLSEKNYFPQ LTVLSVANLL GETIWRVHDD CSGAIEPFST LGID
Length:394
Mass (Da):42,625
Last modified:March 29, 2005 - v2
Checksum:i022EFEF64AF12D60
GO

Sequence cautioni

The sequence AAC27455 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM14963 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003672 Genomic DNA. Translation: AAC27455.1. Sequence problems.
AC004521 Genomic DNA. Translation: AAM14963.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC10434.1.
AY127024 mRNA. Translation: AAM83248.1.
BT001041 mRNA. Translation: AAN46795.1.
PIRiT02409.
RefSeqiNP_181981.2. NM_130017.5. [O64888-1]
UniGeneiAt.27497.
At.43497.
At.73198.

Genome annotation databases

EnsemblPlantsiAT2G44530.1; AT2G44530.1; AT2G44530. [O64888-1]
GeneIDi819061.
GrameneiAT2G44530.1; AT2G44530.1; AT2G44530.
KEGGiath:AT2G44530.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKPRS5_ARATH
AccessioniPrimary (citable) accession number: O64888
Secondary accession number(s): Q8L7T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 29, 2005
Last modified: August 30, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families