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O64882

- BGL17_ARATH

UniProt

O64882 - BGL17_ARATH

Protein

Beta-glucosidase 17

Gene

BGLU17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541SubstrateBy similarity
    Binding sitei158 – 1581SubstrateBy similarity
    Binding sitei203 – 2031SubstrateBy similarity
    Active sitei204 – 2041Proton donorBy similarity
    Binding sitei346 – 3461SubstrateBy similarity
    Active sitei417 – 4171NucleophileBy similarity
    Binding sitei466 – 4661SubstrateBy similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciARA:AT2G44480-MONOMER.
    ARA:GQT-532-MONOMER.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase 17 (EC:3.2.1.21)
    Short name:
    AtBGLU17
    Gene namesi
    Name:BGLU17
    Ordered Locus Names:At2g44480
    ORF Names:F4I1.29
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G44480.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 517494Beta-glucosidase 17PRO_0000389580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi223 ↔ 230By similarity
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO64882.
    PRIDEiO64882.

    Expressioni

    Gene expression databases

    GenevestigatoriO64882.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G44480.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO64882.
    SMRiO64882. Positions 35-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni473 – 4742Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088630.
    InParanoidiO64882.
    KOiK01188.
    OMAiKEWITIN.
    PhylomeDBiO64882.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O64882-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIKSIFIII IISIITSISE LYALDPSFLR LSTSLQRSSF PQDFRFGAAS    50
    SAYQSEGAAN VDGREPSIWD TFTKQYPEKI SDGSNGDVAD EFYYRFKEDV 100
    AHMKEIGLDS FRFSISWSRI LPRGTVAGGV NQAGINFYNH LINELISNGI 150
    RPLVTLFHWD TPQALEDEYG GFLNPQIVKD FVEYVDICFK EFGDRVKEWI 200
    TINEPNMFAV LGYNVGNIAP GRCSSYVQNC TVGNSATEPY LVAHYLILSH 250
    AATVQLYREK YQSFHGGTIG MTIQTYWMIP KYNTPACREA AKRALDFFFG 300
    WFADPITYGD YPKTMRELVG NRLPKFTKKQ SKMVRGSFDF FGLNYYTSRY 350
    VEDVMFYANT NLSYTTDSRV NQTTEKNGVP VGEPTSADWL FICPEGFQDV 400
    LLYIKSKFQN PVILVTENGM PSENDKSLSV NIALNDEAKI KYHQLHLTAL 450
    LEAVSQGADV RGYYIWSLMD DFEWEFGYKY RYGLVYVDFQ DGLKRHLKSS 500
    ALWYHHFLSN SSSYQMD 517
    Length:517
    Mass (Da):59,121
    Last modified:August 1, 1998 - v1
    Checksum:i1A9E4DD65EE1A760
    GO
    Isoform 2 (identifier: O64882-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:415
    Mass (Da):47,698
    Checksum:iDD5945D9BAF200B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti259 – 2591E → V in BAC42451. (PubMed:11910074)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 102102Missing in isoform 2. CuratedVSP_038456Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004521 Genomic DNA. Translation: AAC16094.1.
    CP002685 Genomic DNA. Translation: AEC10426.1.
    CP002685 Genomic DNA. Translation: AEC10427.1.
    AK117809 mRNA. Translation: BAC42451.1.
    AY074629 mRNA. Translation: AAL69445.1.
    PIRiT02403.
    RefSeqiNP_001118525.1. NM_001125053.1. [O64882-2]
    NP_181976.1. NM_130011.2. [O64882-1]
    UniGeneiAt.28778.

    Genome annotation databases

    EnsemblPlantsiAT2G44480.1; AT2G44480.1; AT2G44480. [O64882-1]
    GeneIDi819055.
    KEGGiath:AT2G44480.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004521 Genomic DNA. Translation: AAC16094.1 .
    CP002685 Genomic DNA. Translation: AEC10426.1 .
    CP002685 Genomic DNA. Translation: AEC10427.1 .
    AK117809 mRNA. Translation: BAC42451.1 .
    AY074629 mRNA. Translation: AAL69445.1 .
    PIRi T02403.
    RefSeqi NP_001118525.1. NM_001125053.1. [O64882-2 ]
    NP_181976.1. NM_130011.2. [O64882-1 ]
    UniGenei At.28778.

    3D structure databases

    ProteinModelPortali O64882.
    SMRi O64882. Positions 35-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G44480.1-P.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Proteomic databases

    PaxDbi O64882.
    PRIDEi O64882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G44480.1 ; AT2G44480.1 ; AT2G44480 . [O64882-1 ]
    GeneIDi 819055.
    KEGGi ath:AT2G44480.

    Organism-specific databases

    TAIRi AT2G44480.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088630.
    InParanoidi O64882.
    KOi K01188.
    OMAi KEWITIN.
    PhylomeDBi O64882.

    Enzyme and pathway databases

    BioCyci ARA:AT2G44480-MONOMER.
    ARA:GQT-532-MONOMER.

    Gene expression databases

    Genevestigatori O64882.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiBGL17_ARATH
    AccessioniPrimary (citable) accession number: O64882
    Secondary accession number(s): B3H6D8, Q8GY78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3