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Protein

Beta-glucosidase 17

Gene

BGLU17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541SubstrateBy similarity
Binding sitei158 – 1581SubstrateBy similarity
Binding sitei203 – 2031SubstrateBy similarity
Active sitei204 – 2041Proton donorBy similarity
Binding sitei346 – 3461SubstrateBy similarity
Active sitei417 – 4171NucleophileBy similarity
Binding sitei466 – 4661SubstrateBy similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciARA:AT2G44480-MONOMER.
ARA:GQT-532-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase 17 (EC:3.2.1.21)
Short name:
AtBGLU17
Gene namesi
Name:BGLU17
Ordered Locus Names:At2g44480
ORF Names:F4I1.29
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G44480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 517494Beta-glucosidase 17PRO_0000389580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi223 ↔ 230By similarity
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO64882.
PRIDEiO64882.

Expressioni

Gene expression databases

GenevestigatoriO64882.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G44480.1-P.

Structurei

3D structure databases

ProteinModelPortaliO64882.
SMRiO64882. Positions 34-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni473 – 4742Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088630.
InParanoidiO64882.
KOiK01188.
OMAiKYKNPPI.
PhylomeDBiO64882.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O64882-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIKSIFIII IISIITSISE LYALDPSFLR LSTSLQRSSF PQDFRFGAAS
60 70 80 90 100
SAYQSEGAAN VDGREPSIWD TFTKQYPEKI SDGSNGDVAD EFYYRFKEDV
110 120 130 140 150
AHMKEIGLDS FRFSISWSRI LPRGTVAGGV NQAGINFYNH LINELISNGI
160 170 180 190 200
RPLVTLFHWD TPQALEDEYG GFLNPQIVKD FVEYVDICFK EFGDRVKEWI
210 220 230 240 250
TINEPNMFAV LGYNVGNIAP GRCSSYVQNC TVGNSATEPY LVAHYLILSH
260 270 280 290 300
AATVQLYREK YQSFHGGTIG MTIQTYWMIP KYNTPACREA AKRALDFFFG
310 320 330 340 350
WFADPITYGD YPKTMRELVG NRLPKFTKKQ SKMVRGSFDF FGLNYYTSRY
360 370 380 390 400
VEDVMFYANT NLSYTTDSRV NQTTEKNGVP VGEPTSADWL FICPEGFQDV
410 420 430 440 450
LLYIKSKFQN PVILVTENGM PSENDKSLSV NIALNDEAKI KYHQLHLTAL
460 470 480 490 500
LEAVSQGADV RGYYIWSLMD DFEWEFGYKY RYGLVYVDFQ DGLKRHLKSS
510
ALWYHHFLSN SSSYQMD
Length:517
Mass (Da):59,121
Last modified:July 31, 1998 - v1
Checksum:i1A9E4DD65EE1A760
GO
Isoform 2 (identifier: O64882-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:415
Mass (Da):47,698
Checksum:iDD5945D9BAF200B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591E → V in BAC42451 (PubMed:11910074).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 2. CuratedVSP_038456Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004521 Genomic DNA. Translation: AAC16094.1.
CP002685 Genomic DNA. Translation: AEC10426.1.
CP002685 Genomic DNA. Translation: AEC10427.1.
AK117809 mRNA. Translation: BAC42451.1.
AY074629 mRNA. Translation: AAL69445.1.
PIRiT02403.
RefSeqiNP_001118525.1. NM_001125053.1. [O64882-2]
NP_181976.1. NM_130011.2. [O64882-1]
UniGeneiAt.28778.

Genome annotation databases

EnsemblPlantsiAT2G44480.1; AT2G44480.1; AT2G44480. [O64882-1]
GeneIDi819055.
KEGGiath:AT2G44480.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004521 Genomic DNA. Translation: AAC16094.1.
CP002685 Genomic DNA. Translation: AEC10426.1.
CP002685 Genomic DNA. Translation: AEC10427.1.
AK117809 mRNA. Translation: BAC42451.1.
AY074629 mRNA. Translation: AAL69445.1.
PIRiT02403.
RefSeqiNP_001118525.1. NM_001125053.1. [O64882-2]
NP_181976.1. NM_130011.2. [O64882-1]
UniGeneiAt.28778.

3D structure databases

ProteinModelPortaliO64882.
SMRiO64882. Positions 34-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G44480.1-P.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Proteomic databases

PaxDbiO64882.
PRIDEiO64882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G44480.1; AT2G44480.1; AT2G44480. [O64882-1]
GeneIDi819055.
KEGGiath:AT2G44480.

Organism-specific databases

TAIRiAT2G44480.

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088630.
InParanoidiO64882.
KOiK01188.
OMAiKYKNPPI.
PhylomeDBiO64882.

Enzyme and pathway databases

BioCyciARA:AT2G44480-MONOMER.
ARA:GQT-532-MONOMER.

Gene expression databases

GenevestigatoriO64882.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiBGL17_ARATH
AccessioniPrimary (citable) accession number: O64882
Secondary accession number(s): B3H6D8, Q8GY78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2009
Last sequence update: July 31, 1998
Last modified: January 6, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.