Putative calcium-transporting ATPase 7, plasma membrane-type - Arabidopsis thaliana (Mouse-ear cress)

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Reviewed, UniProtKB/Swiss-Prot O64806 (ACA7_ARATH)

Last modified November 3, 2009. Version 91. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Putative calcium-transporting ATPase 7, plasma membrane-type
    EC=3.6.3.8
Alternative name(s):
    Ca(2+)-ATPase isoform 7

Gene names

Name:	ACA7
Ordered Locus Names:	At2g22950
ORF Names:	T20K9.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	1015 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Enzyme regulation	Activated by calmodulin By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1015

1015

Putative calcium-transporting ATPase 7, plasma membrane-type

PRO_0000046413

Regions

Topological domain

1 – 161

161

Cytoplasmic Potential

Transmembrane

162 – 182

Potential

Topological domain

183 – 200

Lumenal Potential

Transmembrane

201 – 221

Potential

Topological domain

222 – 349

128

Cytoplasmic Potential

Transmembrane

350 – 369

Potential

Topological domain

370 – 399

Lumenal Potential

Transmembrane

400 – 417

Potential

Topological domain

418 – 811

394

Cytoplasmic Potential

Transmembrane

812 – 830

Potential

Topological domain

831 – 841

Lumenal Potential

Transmembrane

842 – 862

Potential

Topological domain

863 – 882

Cytoplasmic Potential

Transmembrane

883 – 905

Potential

Topological domain

906 – 917

Lumenal Potential

Transmembrane

918 – 939

Potential

Topological domain

940 – 957

Cytoplasmic Potential

Transmembrane

958 – 979

Potential

Topological domain

980 – 989

Lumenal Potential

Transmembrane

990 – 1011

Potential

Topological domain

1012 – 1015

Cytoplasmic Potential

Region

20 – 31

Interaction with calmodulin By similarity

Sites

Active site

455

4-aspartylphosphate intermediate By similarity

Metal binding

756

Magnesium By similarity

Metal binding

760

Magnesium By similarity

Amino acid modifications

Modified residue

Phosphoserine; by CPK By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

O64806-1 [UniParc].

Last modified May 1, 1999. Version 2.
Checksum: 57DEE2028316CFC0
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FASTA

1,015

110,773

        10         20         30         40         50         60 
MESYLNSNFD VKAKHSSEEV LEKWRNLCSV VKNPKRRFRF TANLSKRYEA AAMRRTNQEK 

        70         80         90        100        110        120 
LRIAVLVSKA AFQFISGVSP SDYKVPEEVK AAGFDICADE LGSIVEGHDV KKLKFHGGVD 

       130        140        150        160        170        180 
GLSGKLKACP NAGLSTGEPE QLSKRQELFG INKFAESELR SFWVFVWEAL QDMTLMILGV 

       190        200        210        220        230        240 
CAFVSLIVGI ATEGWPQGSH DGLGIVASIL LVVFVTATSD YRQSLQFRDL DKEKKKITVQ 

       250        260        270        280        290        300 
VTRNGFRQKM SIYDLLPGDV VHLAIGDQVP ADGLFLSGFS VVIDESSLTG ESEPVMVTAQ 

       310        320        330        340        350        360 
NPFLLSGTKV QDGSCKMLVT TVGMRTQWGK LMATLSEGGD DETPLQVKLN GVATIIGKIG 

       370        380        390        400        410        420 
LSFAIVTFAV LVQGMFMRKL SLGPHWWWSG DDALELLEYF AIAVTIVVVA VPEGLPLAVT 

       430        440        450        460        470        480 
LSLAFAMKKM MNDKALVRHL AACETMGSAT TICSDKTGTL TTNHMTVVKS CICMNVQDVA 

       490        500        510        520        530        540 
SKSSSLQSDI PEAALKLLLQ LIFNNTGGEV VVNERGKTEI LGTPTETAIL ELGLSLGGKF 

       550        560        570        580        590        600 
QEERQSNKVI KVEPFNSTKK RMGVVIELPE GGRIRAHTKG ASEIVLAACD KVINSSGEVV 

       610        620        630        640        650        660 
PLDDESIKFL NVTIDEFANE ALRTLCLAYM DIESGFSADE GIPEKGFTCI GIVGIKDPVR 

       670        680        690        700        710        720 
PGVRESVELC RRAGIMVRMV TGDNINTAKA IARECGILTD DGIAIEGPVF REKNQEEMLE 

       730        740        750        760        770        780 
LIPKIQVMAR SSPMDKHTLV KQLRTTFDEV VAVTGDGTND APALHEADIG LAMGIAGTEV 

       790        800        810        820        830        840 
AKEIADVIIL DDNFSTIVTV AKWGRSVYIN IQKFVQFQLT VNVVALIVNF SSACLTGSAP 

       850        860        870        880        890        900 
LTAVQLLWVN MIMDTLGALA LATEPPNNEL MKRMPVGRRG NFITNAMWRN ILGQAVYQFI 

       910        920        930        940        950        960 
IIWILQAKGK SMFGLVGSDS TLVLNTLIFN CFVFCQVFNE VSSREMEEID VFKGILDNYV 

       970        980        990       1000       1010 
FVVVIGATVF FQIIIIEFLG TFASTTPLTI VQWFFSIFVG FLGMPIAAGL KKIPV

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Cross-references

Sequence databases
	AC004786 Genomic DNA. Translation: AAM15005.1. AC004401 Genomic DNA. Translation: AAF18608.2.
IPI	IPI00527536.
PIR	H84618.
RefSeq	NP_179879.1.
UniGene	At.52872
3D structure databases
HSSP	HSSP built from PDB template 1EUL based on UniProtKB P04191.
ModBase	Search...
Proteomic databases
PRIDE	O64806.
Genome annotation databases
GeneID	816826.
GenomeReviews	Gene locus AT2G22950 in contig CT485783_GR.
KEGG	ath:AT2G22950.
NMPDR	fig\|3702.1.peg.9314.
Organism-specific databases
TAIR	At2g22950.
Phylogenomic databases
OMA	DCISINS.
Enzyme and pathway databases
BRENDA	3.6.3.8. 302.
Gene expression databases
ArrayExpress	O64806.
Genevestigator	O64806.
GermOnline	AT2G22950. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ACA7_ARATH

Accession

Primary (citable) accession number: O64806

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents