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O64806

- ACA7_ARATH

UniProt

O64806 - ACA7_ARATH

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Protein
Putative calcium-transporting ATPase 7, plasma membrane-type
Gene
ACA7, At2g22950, T20K9.16
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles By similarity.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulationi

Activated by calmodulin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei455 – 45514-aspartylphosphate intermediate By similarity
Metal bindingi756 – 7561Magnesium By similarity
Metal bindingi760 – 7601Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: TAIR
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. pollen development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G22950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative calcium-transporting ATPase 7, plasma membrane-type (EC:3.6.3.8)
Alternative name(s):
Ca(2+)-ATPase isoform 7
Gene namesi
Name:ACA7
Ordered Locus Names:At2g22950
ORF Names:T20K9.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G22950.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 161161Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei162 – 18221Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 20018Lumenal Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 349128Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei350 – 36920Helical; Reviewed prediction
Add
BLAST
Topological domaini370 – 39930Lumenal Reviewed prediction
Add
BLAST
Transmembranei400 – 41718Helical; Reviewed prediction
Add
BLAST
Topological domaini418 – 811394Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei812 – 83019Helical; Reviewed prediction
Add
BLAST
Topological domaini831 – 84111Lumenal Reviewed prediction
Add
BLAST
Transmembranei842 – 86221Helical; Reviewed prediction
Add
BLAST
Topological domaini863 – 88220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei883 – 90523Helical; Reviewed prediction
Add
BLAST
Topological domaini906 – 91712Lumenal Reviewed prediction
Add
BLAST
Transmembranei918 – 93922Helical; Reviewed prediction
Add
BLAST
Topological domaini940 – 95718Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei958 – 97922Helical; Reviewed prediction
Add
BLAST
Topological domaini980 – 98910Lumenal Reviewed prediction
Transmembranei990 – 101122Helical; Reviewed prediction
Add
BLAST
Topological domaini1012 – 10154Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10151015Putative calcium-transporting ATPase 7, plasma membrane-type
PRO_0000046413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine; by CPK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO64806.
PRIDEiO64806.

Expressioni

Gene expression databases

GenevestigatoriO64806.

Interactioni

Protein-protein interaction databases

MINTiMINT-8066298.
STRINGi3702.AT2G22950.1-P.

Structurei

3D structure databases

ProteinModelPortaliO64806.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 3112Interaction with calmodulin By similarity
Add
BLAST

Domaini

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000265623.
InParanoidiO64806.
KOiK01537.
OMAiQRTEDAD.
PhylomeDBiO64806.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O64806-1 [UniParc]FASTAAdd to Basket

« Hide

MESYLNSNFD VKAKHSSEEV LEKWRNLCSV VKNPKRRFRF TANLSKRYEA     50
AAMRRTNQEK LRIAVLVSKA AFQFISGVSP SDYKVPEEVK AAGFDICADE 100
LGSIVEGHDV KKLKFHGGVD GLSGKLKACP NAGLSTGEPE QLSKRQELFG 150
INKFAESELR SFWVFVWEAL QDMTLMILGV CAFVSLIVGI ATEGWPQGSH 200
DGLGIVASIL LVVFVTATSD YRQSLQFRDL DKEKKKITVQ VTRNGFRQKM 250
SIYDLLPGDV VHLAIGDQVP ADGLFLSGFS VVIDESSLTG ESEPVMVTAQ 300
NPFLLSGTKV QDGSCKMLVT TVGMRTQWGK LMATLSEGGD DETPLQVKLN 350
GVATIIGKIG LSFAIVTFAV LVQGMFMRKL SLGPHWWWSG DDALELLEYF 400
AIAVTIVVVA VPEGLPLAVT LSLAFAMKKM MNDKALVRHL AACETMGSAT 450
TICSDKTGTL TTNHMTVVKS CICMNVQDVA SKSSSLQSDI PEAALKLLLQ 500
LIFNNTGGEV VVNERGKTEI LGTPTETAIL ELGLSLGGKF QEERQSNKVI 550
KVEPFNSTKK RMGVVIELPE GGRIRAHTKG ASEIVLAACD KVINSSGEVV 600
PLDDESIKFL NVTIDEFANE ALRTLCLAYM DIESGFSADE GIPEKGFTCI 650
GIVGIKDPVR PGVRESVELC RRAGIMVRMV TGDNINTAKA IARECGILTD 700
DGIAIEGPVF REKNQEEMLE LIPKIQVMAR SSPMDKHTLV KQLRTTFDEV 750
VAVTGDGTND APALHEADIG LAMGIAGTEV AKEIADVIIL DDNFSTIVTV 800
AKWGRSVYIN IQKFVQFQLT VNVVALIVNF SSACLTGSAP LTAVQLLWVN 850
MIMDTLGALA LATEPPNNEL MKRMPVGRRG NFITNAMWRN ILGQAVYQFI 900
IIWILQAKGK SMFGLVGSDS TLVLNTLIFN CFVFCQVFNE VSSREMEEID 950
VFKGILDNYV FVVVIGATVF FQIIIIEFLG TFASTTPLTI VQWFFSIFVG 1000
FLGMPIAAGL KKIPV 1015
Length:1,015
Mass (Da):110,773
Last modified:May 1, 1999 - v2
Checksum:i57DEE2028316CFC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004401 Genomic DNA. Translation: AAF18608.2.
AC004786 Genomic DNA. Translation: AAM15005.1.
CP002685 Genomic DNA. Translation: AEC07380.1.
PIRiH84618.
RefSeqiNP_179879.1. NM_127860.1.
UniGeneiAt.52872.

Genome annotation databases

EnsemblPlantsiAT2G22950.1; AT2G22950.1; AT2G22950.
GeneIDi816826.
KEGGiath:AT2G22950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004401 Genomic DNA. Translation: AAF18608.2 .
AC004786 Genomic DNA. Translation: AAM15005.1 .
CP002685 Genomic DNA. Translation: AEC07380.1 .
PIRi H84618.
RefSeqi NP_179879.1. NM_127860.1.
UniGenei At.52872.

3D structure databases

ProteinModelPortali O64806.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8066298.
STRINGi 3702.AT2G22950.1-P.

Proteomic databases

PaxDbi O64806.
PRIDEi O64806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G22950.1 ; AT2G22950.1 ; AT2G22950 .
GeneIDi 816826.
KEGGi ath:AT2G22950.

Organism-specific databases

TAIRi AT2G22950.

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000265623.
InParanoidi O64806.
KOi K01537.
OMAi QRTEDAD.
PhylomeDBi O64806.

Enzyme and pathway databases

BioCyci ARA:AT2G22950-MONOMER.

Miscellaneous databases

PROi O64806.

Gene expression databases

Genevestigatori O64806.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
PR00120. HATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiACA7_ARATH
AccessioniPrimary (citable) accession number: O64806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi