Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O64806 (ACA7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative calcium-transporting ATPase 7, plasma membrane-type

EC=3.6.3.8
Alternative name(s):
Ca(2+)-ATPase isoform 7
Gene names
Name:ACA7
Ordered Locus Names:At2g22950
ORF Names:T20K9.16
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length1015 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles By similarity.

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulation

Activated by calmodulin By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10151015Putative calcium-transporting ATPase 7, plasma membrane-type
PRO_0000046413

Regions

Topological domain1 – 161161Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 20018Lumenal Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 349128Cytoplasmic Potential
Transmembrane350 – 36920Helical; Potential
Topological domain370 – 39930Lumenal Potential
Transmembrane400 – 41718Helical; Potential
Topological domain418 – 811394Cytoplasmic Potential
Transmembrane812 – 83019Helical; Potential
Topological domain831 – 84111Lumenal Potential
Transmembrane842 – 86221Helical; Potential
Topological domain863 – 88220Cytoplasmic Potential
Transmembrane883 – 90523Helical; Potential
Topological domain906 – 91712Lumenal Potential
Transmembrane918 – 93922Helical; Potential
Topological domain940 – 95718Cytoplasmic Potential
Transmembrane958 – 97922Helical; Potential
Topological domain980 – 98910Lumenal Potential
Transmembrane990 – 101122Helical; Potential
Topological domain1012 – 10154Cytoplasmic Potential
Region20 – 3112Interaction with calmodulin By similarity

Sites

Active site45514-aspartylphosphate intermediate By similarity
Metal binding7561Magnesium By similarity
Metal binding7601Magnesium By similarity

Amino acid modifications

Modified residue451Phosphoserine; by CPK By similarity

Sequences

Sequence LengthMass (Da)Tools
O64806 [UniParc].

Last modified May 1, 1999. Version 2.
Checksum: 57DEE2028316CFC0

FASTA1,015110,773
        10         20         30         40         50         60 
MESYLNSNFD VKAKHSSEEV LEKWRNLCSV VKNPKRRFRF TANLSKRYEA AAMRRTNQEK 

        70         80         90        100        110        120 
LRIAVLVSKA AFQFISGVSP SDYKVPEEVK AAGFDICADE LGSIVEGHDV KKLKFHGGVD 

       130        140        150        160        170        180 
GLSGKLKACP NAGLSTGEPE QLSKRQELFG INKFAESELR SFWVFVWEAL QDMTLMILGV 

       190        200        210        220        230        240 
CAFVSLIVGI ATEGWPQGSH DGLGIVASIL LVVFVTATSD YRQSLQFRDL DKEKKKITVQ 

       250        260        270        280        290        300 
VTRNGFRQKM SIYDLLPGDV VHLAIGDQVP ADGLFLSGFS VVIDESSLTG ESEPVMVTAQ 

       310        320        330        340        350        360 
NPFLLSGTKV QDGSCKMLVT TVGMRTQWGK LMATLSEGGD DETPLQVKLN GVATIIGKIG 

       370        380        390        400        410        420 
LSFAIVTFAV LVQGMFMRKL SLGPHWWWSG DDALELLEYF AIAVTIVVVA VPEGLPLAVT 

       430        440        450        460        470        480 
LSLAFAMKKM MNDKALVRHL AACETMGSAT TICSDKTGTL TTNHMTVVKS CICMNVQDVA 

       490        500        510        520        530        540 
SKSSSLQSDI PEAALKLLLQ LIFNNTGGEV VVNERGKTEI LGTPTETAIL ELGLSLGGKF 

       550        560        570        580        590        600 
QEERQSNKVI KVEPFNSTKK RMGVVIELPE GGRIRAHTKG ASEIVLAACD KVINSSGEVV 

       610        620        630        640        650        660 
PLDDESIKFL NVTIDEFANE ALRTLCLAYM DIESGFSADE GIPEKGFTCI GIVGIKDPVR 

       670        680        690        700        710        720 
PGVRESVELC RRAGIMVRMV TGDNINTAKA IARECGILTD DGIAIEGPVF REKNQEEMLE 

       730        740        750        760        770        780 
LIPKIQVMAR SSPMDKHTLV KQLRTTFDEV VAVTGDGTND APALHEADIG LAMGIAGTEV 

       790        800        810        820        830        840 
AKEIADVIIL DDNFSTIVTV AKWGRSVYIN IQKFVQFQLT VNVVALIVNF SSACLTGSAP 

       850        860        870        880        890        900 
LTAVQLLWVN MIMDTLGALA LATEPPNNEL MKRMPVGRRG NFITNAMWRN ILGQAVYQFI 

       910        920        930        940        950        960 
IIWILQAKGK SMFGLVGSDS TLVLNTLIFN CFVFCQVFNE VSSREMEEID VFKGILDNYV 

       970        980        990       1000       1010 
FVVVIGATVF FQIIIIEFLG TFASTTPLTI VQWFFSIFVG FLGMPIAAGL KKIPV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004401 Genomic DNA. Translation: AAF18608.2.
AC004786 Genomic DNA. Translation: AAM15005.1.
CP002685 Genomic DNA. Translation: AEC07380.1.
PIRH84618.
RefSeqNP_179879.1. NM_127860.1.
UniGeneAt.52872.

3D structure databases

ProteinModelPortalO64806.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8066298.
STRING3702.AT2G22950.1-P.

Proteomic databases

PaxDbO64806.
PRIDEO64806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G22950.1; AT2G22950.1; AT2G22950.
GeneID816826.
KEGGath:AT2G22950.

Organism-specific databases

TAIRAT2G22950.

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000265623.
InParanoidO64806.
KOK01537.
OMAQRTEDAD.
PhylomeDBO64806.

Enzyme and pathway databases

BioCycARA:AT2G22950-MONOMER.

Gene expression databases

GenevestigatorO64806.

Family and domain databases

Gene3D1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO64806.

Entry information

Entry nameACA7_ARATH
AccessionPrimary (citable) accession number: O64806
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names