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O64806

- ACA7_ARATH

UniProt

O64806 - ACA7_ARATH

Protein

Putative calcium-transporting ATPase 7, plasma membrane-type

Gene

ACA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.By similarity

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Enzyme regulationi

    Activated by calmodulin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei455 – 45514-aspartylphosphate intermediateBy similarity
    Metal bindingi756 – 7561MagnesiumBy similarity
    Metal bindingi760 – 7601MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: TAIR
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. pollen development Source: TAIR

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G22950-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative calcium-transporting ATPase 7, plasma membrane-type (EC:3.6.3.8)
    Alternative name(s):
    Ca(2+)-ATPase isoform 7
    Gene namesi
    Name:ACA7
    Ordered Locus Names:At2g22950
    ORF Names:T20K9.16
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G22950.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10151015Putative calcium-transporting ATPase 7, plasma membrane-typePRO_0000046413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Phosphoserine; by CPKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO64806.
    PRIDEiO64806.

    Expressioni

    Gene expression databases

    GenevestigatoriO64806.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8066298.
    STRINGi3702.AT2G22950.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO64806.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 161161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20018LumenalSequence AnalysisAdd
    BLAST
    Topological domaini222 – 349128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini370 – 39930LumenalSequence AnalysisAdd
    BLAST
    Topological domaini418 – 811394CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini831 – 84111LumenalSequence AnalysisAdd
    BLAST
    Topological domaini863 – 88220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini906 – 91712LumenalSequence AnalysisAdd
    BLAST
    Topological domaini940 – 95718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini980 – 98910LumenalSequence Analysis
    Topological domaini1012 – 10154CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 36920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei400 – 41718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei812 – 83019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei842 – 86221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei883 – 90523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei918 – 93922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei958 – 97922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei990 – 101122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 3112Interaction with calmodulinBy similarityAdd
    BLAST

    Domaini

    The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265623.
    InParanoidiO64806.
    KOiK01537.
    OMAiQRTEDAD.
    PhylomeDBiO64806.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR024750. Ca_ATPase_N_dom.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF12515. CaATP_NAI. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O64806-1 [UniParc]FASTAAdd to Basket

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    MESYLNSNFD VKAKHSSEEV LEKWRNLCSV VKNPKRRFRF TANLSKRYEA     50
    AAMRRTNQEK LRIAVLVSKA AFQFISGVSP SDYKVPEEVK AAGFDICADE 100
    LGSIVEGHDV KKLKFHGGVD GLSGKLKACP NAGLSTGEPE QLSKRQELFG 150
    INKFAESELR SFWVFVWEAL QDMTLMILGV CAFVSLIVGI ATEGWPQGSH 200
    DGLGIVASIL LVVFVTATSD YRQSLQFRDL DKEKKKITVQ VTRNGFRQKM 250
    SIYDLLPGDV VHLAIGDQVP ADGLFLSGFS VVIDESSLTG ESEPVMVTAQ 300
    NPFLLSGTKV QDGSCKMLVT TVGMRTQWGK LMATLSEGGD DETPLQVKLN 350
    GVATIIGKIG LSFAIVTFAV LVQGMFMRKL SLGPHWWWSG DDALELLEYF 400
    AIAVTIVVVA VPEGLPLAVT LSLAFAMKKM MNDKALVRHL AACETMGSAT 450
    TICSDKTGTL TTNHMTVVKS CICMNVQDVA SKSSSLQSDI PEAALKLLLQ 500
    LIFNNTGGEV VVNERGKTEI LGTPTETAIL ELGLSLGGKF QEERQSNKVI 550
    KVEPFNSTKK RMGVVIELPE GGRIRAHTKG ASEIVLAACD KVINSSGEVV 600
    PLDDESIKFL NVTIDEFANE ALRTLCLAYM DIESGFSADE GIPEKGFTCI 650
    GIVGIKDPVR PGVRESVELC RRAGIMVRMV TGDNINTAKA IARECGILTD 700
    DGIAIEGPVF REKNQEEMLE LIPKIQVMAR SSPMDKHTLV KQLRTTFDEV 750
    VAVTGDGTND APALHEADIG LAMGIAGTEV AKEIADVIIL DDNFSTIVTV 800
    AKWGRSVYIN IQKFVQFQLT VNVVALIVNF SSACLTGSAP LTAVQLLWVN 850
    MIMDTLGALA LATEPPNNEL MKRMPVGRRG NFITNAMWRN ILGQAVYQFI 900
    IIWILQAKGK SMFGLVGSDS TLVLNTLIFN CFVFCQVFNE VSSREMEEID 950
    VFKGILDNYV FVVVIGATVF FQIIIIEFLG TFASTTPLTI VQWFFSIFVG 1000
    FLGMPIAAGL KKIPV 1015
    Length:1,015
    Mass (Da):110,773
    Last modified:May 1, 1999 - v2
    Checksum:i57DEE2028316CFC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004401 Genomic DNA. Translation: AAF18608.2.
    AC004786 Genomic DNA. Translation: AAM15005.1.
    CP002685 Genomic DNA. Translation: AEC07380.1.
    PIRiH84618.
    RefSeqiNP_179879.1. NM_127860.1.
    UniGeneiAt.52872.

    Genome annotation databases

    EnsemblPlantsiAT2G22950.1; AT2G22950.1; AT2G22950.
    GeneIDi816826.
    KEGGiath:AT2G22950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004401 Genomic DNA. Translation: AAF18608.2 .
    AC004786 Genomic DNA. Translation: AAM15005.1 .
    CP002685 Genomic DNA. Translation: AEC07380.1 .
    PIRi H84618.
    RefSeqi NP_179879.1. NM_127860.1.
    UniGenei At.52872.

    3D structure databases

    ProteinModelPortali O64806.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8066298.
    STRINGi 3702.AT2G22950.1-P.

    Proteomic databases

    PaxDbi O64806.
    PRIDEi O64806.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G22950.1 ; AT2G22950.1 ; AT2G22950 .
    GeneIDi 816826.
    KEGGi ath:AT2G22950.

    Organism-specific databases

    TAIRi AT2G22950.

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265623.
    InParanoidi O64806.
    KOi K01537.
    OMAi QRTEDAD.
    PhylomeDBi O64806.

    Enzyme and pathway databases

    BioCyci ARA:AT2G22950-MONOMER.

    Miscellaneous databases

    PROi O64806.

    Gene expression databases

    Genevestigatori O64806.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR024750. Ca_ATPase_N_dom.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF12515. CaATP_NAI. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiACA7_ARATH
    AccessioniPrimary (citable) accession number: O64806
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3