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Protein

Thioredoxin O1, mitochondrial

Gene

At2g35010

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity. Reduced by thioredoxin reductases NTRA and NTRB.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei118NucleophileBy similarity1
Sitei119Contributes to redox potential valueBy similarity1
Sitei120Contributes to redox potential valueBy similarity1
Active sitei121NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin O1, mitochondrial
Short name:
AtTrxo1
Gene namesi
Ordered Locus Names:At2g35010
ORF Names:F19I3.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G35010.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
ChainiPRO_000039453743 – 194Thioredoxin O1, mitochondrialAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineBy similarity1
Disulfide bondi118 ↔ 121Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO64764.
PRIDEiO64764.

PTM databases

SwissPalmiO64764.

Expressioni

Gene expression databases

GenevisibleiO64764. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G35010.1.

Structurei

3D structure databases

ProteinModelPortaliO64764.
SMRiO64764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 194ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiO64764.
KOiK03671.
OMAiGNWSIVR.
OrthoDBiEOG09360UVJ.
PhylomeDBiO64764.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O64764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNWSIVRK VLHRQFSTLR SSTPSSRLST SIRPLVLAPN SISSLIARNS
60 70 80 90 100
LFTASNIGPS IDFNFSNTSL PHRRSLCSEA GGENGVVLVK SEEEFINAMS
110 120 130 140 150
KAQDGSLPSV FYFTAAWCGP CRFISPVIVE LSKQYPDVTT YKVDIDEGGI
160 170 180 190
SNTISKLNIT AVPTLHFFKG GSKKGEVVGA DVTKLKNLME QLYK
Length:194
Mass (Da):21,191
Last modified:August 1, 1998 - v1
Checksum:i1DA980E60614606D
GO

Sequence cautioni

The sequence BAC43652 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110V → A in BAC43652 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004238 Genomic DNA. Translation: AAC12840.1.
CP002685 Genomic DNA. Translation: AEC09048.1.
CP002685 Genomic DNA. Translation: AEC09049.1.
BT025773 mRNA. Translation: ABF83663.1.
AK119076 mRNA. Translation: BAC43652.1. Different initiation.
PIRiT00482.
RefSeqiNP_001078006.1. NM_001084537.1.
NP_181046.1. NM_129053.6.
UniGeneiAt.37724.

Genome annotation databases

EnsemblPlantsiAT2G35010.1; AT2G35010.1; AT2G35010.
AT2G35010.2; AT2G35010.2; AT2G35010.
GeneIDi818065.
GrameneiAT2G35010.1; AT2G35010.1; AT2G35010.
AT2G35010.2; AT2G35010.2; AT2G35010.
KEGGiath:AT2G35010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004238 Genomic DNA. Translation: AAC12840.1.
CP002685 Genomic DNA. Translation: AEC09048.1.
CP002685 Genomic DNA. Translation: AEC09049.1.
BT025773 mRNA. Translation: ABF83663.1.
AK119076 mRNA. Translation: BAC43652.1. Different initiation.
PIRiT00482.
RefSeqiNP_001078006.1. NM_001084537.1.
NP_181046.1. NM_129053.6.
UniGeneiAt.37724.

3D structure databases

ProteinModelPortaliO64764.
SMRiO64764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G35010.1.

PTM databases

SwissPalmiO64764.

Proteomic databases

PaxDbiO64764.
PRIDEiO64764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G35010.1; AT2G35010.1; AT2G35010.
AT2G35010.2; AT2G35010.2; AT2G35010.
GeneIDi818065.
GrameneiAT2G35010.1; AT2G35010.1; AT2G35010.
AT2G35010.2; AT2G35010.2; AT2G35010.
KEGGiath:AT2G35010.

Organism-specific databases

TAIRiAT2G35010.

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiO64764.
KOiK03671.
OMAiGNWSIVR.
OrthoDBiEOG09360UVJ.
PhylomeDBiO64764.

Miscellaneous databases

PROiO64764.

Gene expression databases

GenevisibleiO64764. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXO1_ARATH
AccessioniPrimary (citable) accession number: O64764
Secondary accession number(s): Q8GW51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.