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O64645 (SOC1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MADS-box protein SOC1
Alternative name(s):
Agamous-like MADS-box protein AGL20
Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1
Gene names
Name:SOC1
Synonyms:AGL20
Ordered Locus Names:At2g45660
ORF Names:F17K2.19
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. Ref.5 Ref.8 Ref.10 Ref.11

Subunit structure

Forms a heterodimer with AGL24 through MADS-box domain. Interacts with AGL15, AGL16 and AGL19. Ref.6 Ref.10

Subcellular location

Nucleus. Cytoplasm. Note: Translocation from the cytoplasm to the nucleus in the presence of AGL24. Ref.10

Tissue specificity

Widely expressed. Not found in the apical meristem of short-day grown plants in vegetative stage.

Developmental stage

Rapidly up-regulated in apical meristems during the transition to flowering. Transiently expressed in inflorescence meristem. Re-appears in stage 3 flowers, in the central dome that later will develop into stamens and carpels. Ref.11

Induction

Up-regulated by gibberellins, vernalization and under long-day conditions. Gradual increase during vegetative growth. Induced by AGL24 at the shoot apex at the floral transitional stage. Repressed by SVP during the early stages of flower development. Inhibited by AP1 in emerging floral meristems. Ref.7 Ref.8 Ref.11

Disruption phenotype

Plants are late-flowering. Ref.1

Sequence similarities

Contains 1 K-box domain.

Contains 1 MADS-box domain.

Ontologies

Keywords
   Biological processDifferentiation
Flowering
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processflower development

Traceable author statement Ref.5. Source: TAIR

maintenance of inflorescence meristem identity

Inferred from genetic interaction PubMed 20626659. Source: TAIR

positive regulation of flower development

Inferred from mutant phenotype PubMed 10834834Ref.1. Source: TAIR

positive regulation of transcription, DNA-templated

Inferred from expression pattern Ref.8. Source: UniProtKB

protein import into nucleus, translocation

Inferred from direct assay Ref.10. Source: UniProtKB

response to cold

Inferred from expression pattern PubMed 16507079. Source: TAIR

response to gibberellin

Inferred from expression pattern Ref.10. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay Ref.10. Source: UniProtKB

nucleus

Inferred from direct assay Ref.10. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.6Ref.10. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity PubMed 11118137Ref.1PubMed 12837945. Source: TAIR

transcription factor binding

Inferred from physical interaction Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214MADS-box protein SOC1
PRO_0000199486

Regions

Domain3 – 5755MADS-box
Domain87 – 17791K-box

Experimental info

Mutagenesis241R → K in sso36; suppression of early flowering time mediated by SOC1 over-expression. Ref.10
Mutagenesis341E → K in sso11; partial suppression of early flowering time mediated by SOC1 overexpression. Ref.10
Mutagenesis1131G → E in sso4; partial suppression of early flowering time mediated by SOC1 overexpression. Ref.10

Sequences

Sequence LengthMass (Da)Tools
O64645 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: B4D39151DE541F8D

FASTA21424,533
        10         20         30         40         50         60 
MVRGKTQMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVSLIIFSP KGKLYEFASS 

        70         80         90        100        110        120 
NMQDTIDRYL RHTKDRVSTK PVSEENMQHL KYEAANMMKK IEQLEASKRK LLGEGIGTCS 

       130        140        150        160        170        180 
IEELQQIEQQ LEKSVKCIRA RKTQVFKEQI EQLKQKEKAL AAENEKLSEK WGSHESEVWS 

       190        200        210 
NKNQESTGRG DEESSPSSEV ETQLFIGLPC SSRK 

« Hide

References

« Hide 'large scale' references
[1]"A MADS domain gene involved in the transition to flowering in Arabidopsis."
Borner R., Kampmann G., Chandler J., Gleissner R., Wisman E., Apel K., Melzer S.
Plant J. 24:591-599(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis."
Lee H., Suh S.S., Park E., Cho E., Ahn J.H., Kim S.G., Lee J.S., Kwon Y.M., Lee I.
Genes Dev. 14:2366-2376(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: cv. Landsberg erecta.
[6]"Comprehensive interaction map of the Arabidopsis MADS Box transcription factors."
de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R., Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B., Angenent G.C.
Plant Cell 17:1424-1433(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AGL15; AGL16 AND AGL19.
[7]"Specification of Arabidopsis floral meristem identity by repression of flowering time genes."
Liu C., Zhou J., Bracha-Drori K., Yalovsky S., Ito T., Yu H.
Development 134:1901-1910(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY AP1.
[8]"Direct interaction of AGL24 and SOC1 integrates flowering signals in Arabidopsis."
Liu C., Chen H., Er H.L., Soo H.M., Kumar P.P., Han J.-H., Liou Y.C., Yu H.
Development 135:1481-1491(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION BY AGL24.
[9]"FLC or not FLC: the other side of vernalization."
Alexandre C.M., Hennig L.
J. Exp. Bot. 59:1127-1135(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[10]"SOC1 translocated to the nucleus by interaction with AGL24 directly regulates leafy."
Lee J., Oh M., Park H., Lee I.
Plant J. 55:832-843(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF ARG-24; GLU-34 AND GLY-113, INTERACTION WITH AGL24, SUBCELLULAR LOCATION.
[11]"The Arabidopsis floral meristem identity genes AP1, AGL24 and SVP directly repress class B and C floral homeotic genes."
Gregis V., Sessa A., Dorca-Fornell C., Kater M.M.
Plant J. 60:626-637(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC003680 Genomic DNA. Translation: AAC06175.1.
CP002685 Genomic DNA. Translation: AEC10583.1.
AY007726 mRNA. Translation: AAG16297.1.
AF385731 mRNA. Translation: AAK60321.1.
AY093967 mRNA. Translation: AAM16228.1.
PIRT00879.
RefSeqNP_182090.1. NM_130128.3.
UniGeneAt.25546.

3D structure databases

ProteinModelPortalO64645.
SMRO64645. Positions 3-69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid4510. 33 interactions.
IntActO64645. 35 interactions.
STRING3702.AT2G45660.1-P.

Proteomic databases

PRIDEO64645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G45660.1; AT2G45660.1; AT2G45660.
GeneID819174.
KEGGath:AT2G45660.

Organism-specific databases

GeneFarm3500. 353.
TAIRAT2G45660.

Phylogenomic databases

eggNOGCOG5068.
HOGENOMHOG000155301.
InParanoidO64645.
OMAVKCIRAR.
PhylomeDBO64645.

Gene expression databases

GenevestigatorO64645.

Family and domain databases

InterProIPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSPR00404. MADSDOMAIN.
SMARTSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMSSF55455. SSF55455. 1 hit.
PROSITEPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSOC1_ARATH
AccessionPrimary (citable) accession number: O64645
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names