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O64645

- SOC1_ARATH

UniProt

O64645 - SOC1_ARATH

Protein

MADS-box protein SOC1

Gene

SOC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development.4 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: TAIR
    4. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. flower development Source: TAIR
    2. maintenance of inflorescence meristem identity Source: TAIR
    3. positive regulation of flower development Source: TAIR
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. protein import into nucleus, translocation Source: UniProtKB
    6. response to cold Source: TAIR
    7. response to gibberellin Source: UniProtKB
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Flowering, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MADS-box protein SOC1
    Alternative name(s):
    Agamous-like MADS-box protein AGL20
    Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1
    Gene namesi
    Name:SOC1
    Synonyms:AGL20
    Ordered Locus Names:At2g45660
    ORF Names:F17K2.19
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G45660.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication
    Note: Translocation from the cytoplasm to the nucleus in the presence of AGL24.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Plants are late-flowering.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi24 – 241R → K in sso36; suppression of early flowering time mediated by SOC1 over-expression. 1 Publication
    Mutagenesisi34 – 341E → K in sso11; partial suppression of early flowering time mediated by SOC1 overexpression. 1 Publication
    Mutagenesisi113 – 1131G → E in sso4; partial suppression of early flowering time mediated by SOC1 overexpression. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214MADS-box protein SOC1PRO_0000199486Add
    BLAST

    Proteomic databases

    PRIDEiO64645.

    Expressioni

    Tissue specificityi

    Widely expressed. Not found in the apical meristem of short-day grown plants in vegetative stage.

    Developmental stagei

    Rapidly up-regulated in apical meristems during the transition to flowering. Transiently expressed in inflorescence meristem. Re-appears in stage 3 flowers, in the central dome that later will develop into stamens and carpels.1 Publication

    Inductioni

    Up-regulated by gibberellins, vernalization and under long-day conditions. Gradual increase during vegetative growth. Induced by AGL24 at the shoot apex at the floral transitional stage. Repressed by SVP during the early stages of flower development. Inhibited by AP1 in emerging floral meristems.3 Publications

    Gene expression databases

    GenevestigatoriO64645.

    Interactioni

    Subunit structurei

    Forms a heterodimer with AGL24 through MADS-box domain. Interacts with AGL15, AGL16 and AGL19.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGL8Q388764EBI-592041,EBI-621912
    AP1P356315EBI-592041,EBI-592003
    CALQ390814EBI-592041,EBI-592136
    PIN1Q9SL423EBI-592041,EBI-2618990

    Protein-protein interaction databases

    BioGridi4510. 33 interactions.
    DIPiDIP-33799N.
    IntActiO64645. 35 interactions.
    STRINGi3702.AT2G45660.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO64645.
    SMRiO64645. Positions 3-69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 5755MADS-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 17791K-boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 K-box domain.PROSITE-ProRule annotation
    Contains 1 MADS-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5068.
    HOGENOMiHOG000155301.
    InParanoidiO64645.
    OMAiVKCIRAR.
    PhylomeDBiO64645.

    Family and domain databases

    InterProiIPR002487. TF_Kbox.
    IPR002100. TF_MADSbox.
    [Graphical view]
    PfamiPF01486. K-box. 1 hit.
    PF00319. SRF-TF. 1 hit.
    [Graphical view]
    PRINTSiPR00404. MADSDOMAIN.
    SMARTiSM00432. MADS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55455. SSF55455. 1 hit.
    PROSITEiPS51297. K_BOX. 1 hit.
    PS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O64645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRGKTQMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVSLIIFSP    50
    KGKLYEFASS NMQDTIDRYL RHTKDRVSTK PVSEENMQHL KYEAANMMKK 100
    IEQLEASKRK LLGEGIGTCS IEELQQIEQQ LEKSVKCIRA RKTQVFKEQI 150
    EQLKQKEKAL AAENEKLSEK WGSHESEVWS NKNQESTGRG DEESSPSSEV 200
    ETQLFIGLPC SSRK 214
    Length:214
    Mass (Da):24,533
    Last modified:August 1, 1998 - v1
    Checksum:iB4D39151DE541F8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC003680 Genomic DNA. Translation: AAC06175.1.
    CP002685 Genomic DNA. Translation: AEC10583.1.
    AY007726 mRNA. Translation: AAG16297.1.
    AF385731 mRNA. Translation: AAK60321.1.
    AY093967 mRNA. Translation: AAM16228.1.
    PIRiT00879.
    RefSeqiNP_182090.1. NM_130128.3.
    UniGeneiAt.25546.

    Genome annotation databases

    EnsemblPlantsiAT2G45660.1; AT2G45660.1; AT2G45660.
    GeneIDi819174.
    KEGGiath:AT2G45660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC003680 Genomic DNA. Translation: AAC06175.1 .
    CP002685 Genomic DNA. Translation: AEC10583.1 .
    AY007726 mRNA. Translation: AAG16297.1 .
    AF385731 mRNA. Translation: AAK60321.1 .
    AY093967 mRNA. Translation: AAM16228.1 .
    PIRi T00879.
    RefSeqi NP_182090.1. NM_130128.3.
    UniGenei At.25546.

    3D structure databases

    ProteinModelPortali O64645.
    SMRi O64645. Positions 3-69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 4510. 33 interactions.
    DIPi DIP-33799N.
    IntActi O64645. 35 interactions.
    STRINGi 3702.AT2G45660.1-P.

    Proteomic databases

    PRIDEi O64645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G45660.1 ; AT2G45660.1 ; AT2G45660 .
    GeneIDi 819174.
    KEGGi ath:AT2G45660.

    Organism-specific databases

    GeneFarmi 3500. 353.
    TAIRi AT2G45660.

    Phylogenomic databases

    eggNOGi COG5068.
    HOGENOMi HOG000155301.
    InParanoidi O64645.
    OMAi VKCIRAR.
    PhylomeDBi O64645.

    Gene expression databases

    Genevestigatori O64645.

    Family and domain databases

    InterProi IPR002487. TF_Kbox.
    IPR002100. TF_MADSbox.
    [Graphical view ]
    Pfami PF01486. K-box. 1 hit.
    PF00319. SRF-TF. 1 hit.
    [Graphical view ]
    PRINTSi PR00404. MADSDOMAIN.
    SMARTi SM00432. MADS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55455. SSF55455. 1 hit.
    PROSITEi PS51297. K_BOX. 1 hit.
    PS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A MADS domain gene involved in the transition to flowering in Arabidopsis."
      Borner R., Kampmann G., Chandler J., Gleissner R., Wisman E., Apel K., Melzer S.
      Plant J. 24:591-599(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis."
      Lee H., Suh S.S., Park E., Cho E., Ahn J.H., Kim S.G., Lee J.S., Kwon Y.M., Lee I.
      Genes Dev. 14:2366-2376(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: cv. Landsberg erecta.
    6. Cited for: INTERACTION WITH AGL15; AGL16 AND AGL19.
    7. "Specification of Arabidopsis floral meristem identity by repression of flowering time genes."
      Liu C., Zhou J., Bracha-Drori K., Yalovsky S., Ito T., Yu H.
      Development 134:1901-1910(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY AP1.
    8. "Direct interaction of AGL24 and SOC1 integrates flowering signals in Arabidopsis."
      Liu C., Chen H., Er H.L., Soo H.M., Kumar P.P., Han J.-H., Liou Y.C., Yu H.
      Development 135:1481-1491(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY AGL24.
    9. "FLC or not FLC: the other side of vernalization."
      Alexandre C.M., Hennig L.
      J. Exp. Bot. 59:1127-1135(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "SOC1 translocated to the nucleus by interaction with AGL24 directly regulates leafy."
      Lee J., Oh M., Park H., Lee I.
      Plant J. 55:832-843(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ARG-24; GLU-34 AND GLY-113, INTERACTION WITH AGL24, SUBCELLULAR LOCATION.
    11. "The Arabidopsis floral meristem identity genes AP1, AGL24 and SVP directly repress class B and C floral homeotic genes."
      Gregis V., Sessa A., Dorca-Fornell C., Kater M.M.
      Plant J. 60:626-637(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiSOC1_ARATH
    AccessioniPrimary (citable) accession number: O64645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3