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O64645

- SOC1_ARATH

UniProt

O64645 - SOC1_ARATH

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Protein
MADS-box protein SOC1
Gene
SOC1, AGL20, At2g45660, F17K2.19
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development.4 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: TAIR
  4. transcription factor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. flower development Source: TAIR
  2. maintenance of inflorescence meristem identity Source: TAIR
  3. positive regulation of flower development Source: TAIR
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. protein import into nucleus, translocation Source: UniProtKB
  6. response to cold Source: TAIR
  7. response to gibberellin Source: UniProtKB
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Flowering, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box protein SOC1
Alternative name(s):
Agamous-like MADS-box protein AGL20
Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1
Gene namesi
Name:SOC1
Synonyms:AGL20
Ordered Locus Names:At2g45660
ORF Names:F17K2.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G45660.

Subcellular locationi

Nucleus. Cytoplasm
Note: Translocation from the cytoplasm to the nucleus in the presence of AGL24.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants are late-flowering.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi24 – 241R → K in sso36; suppression of early flowering time mediated by SOC1 over-expression. 1 Publication
Mutagenesisi34 – 341E → K in sso11; partial suppression of early flowering time mediated by SOC1 overexpression. 1 Publication
Mutagenesisi113 – 1131G → E in sso4; partial suppression of early flowering time mediated by SOC1 overexpression. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214MADS-box protein SOC1
PRO_0000199486Add
BLAST

Proteomic databases

PRIDEiO64645.

Expressioni

Tissue specificityi

Widely expressed. Not found in the apical meristem of short-day grown plants in vegetative stage.

Developmental stagei

Rapidly up-regulated in apical meristems during the transition to flowering. Transiently expressed in inflorescence meristem. Re-appears in stage 3 flowers, in the central dome that later will develop into stamens and carpels.1 Publication

Inductioni

Up-regulated by gibberellins, vernalization and under long-day conditions. Gradual increase during vegetative growth. Induced by AGL24 at the shoot apex at the floral transitional stage. Repressed by SVP during the early stages of flower development. Inhibited by AP1 in emerging floral meristems.3 Publications

Gene expression databases

GenevestigatoriO64645.

Interactioni

Subunit structurei

Forms a heterodimer with AGL24 through MADS-box domain. Interacts with AGL15, AGL16 and AGL19.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGL8Q388764EBI-592041,EBI-621912
AP1P356315EBI-592041,EBI-592003
CALQ390814EBI-592041,EBI-592136
PIN1Q9SL423EBI-592041,EBI-2618990

Protein-protein interaction databases

BioGridi4510. 33 interactions.
IntActiO64645. 35 interactions.
STRINGi3702.AT2G45660.1-P.

Structurei

3D structure databases

ProteinModelPortaliO64645.
SMRiO64645. Positions 3-69.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5755MADS-box
Add
BLAST
Domaini87 – 17791K-box
Add
BLAST

Sequence similaritiesi

Contains 1 K-box domain.
Contains 1 MADS-box domain.

Phylogenomic databases

eggNOGiCOG5068.
HOGENOMiHOG000155301.
InParanoidiO64645.
OMAiVKCIRAR.
PhylomeDBiO64645.

Family and domain databases

InterProiIPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O64645-1 [UniParc]FASTAAdd to Basket

« Hide

MVRGKTQMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVSLIIFSP    50
KGKLYEFASS NMQDTIDRYL RHTKDRVSTK PVSEENMQHL KYEAANMMKK 100
IEQLEASKRK LLGEGIGTCS IEELQQIEQQ LEKSVKCIRA RKTQVFKEQI 150
EQLKQKEKAL AAENEKLSEK WGSHESEVWS NKNQESTGRG DEESSPSSEV 200
ETQLFIGLPC SSRK 214
Length:214
Mass (Da):24,533
Last modified:August 1, 1998 - v1
Checksum:iB4D39151DE541F8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003680 Genomic DNA. Translation: AAC06175.1.
CP002685 Genomic DNA. Translation: AEC10583.1.
AY007726 mRNA. Translation: AAG16297.1.
AF385731 mRNA. Translation: AAK60321.1.
AY093967 mRNA. Translation: AAM16228.1.
PIRiT00879.
RefSeqiNP_182090.1. NM_130128.3.
UniGeneiAt.25546.

Genome annotation databases

EnsemblPlantsiAT2G45660.1; AT2G45660.1; AT2G45660.
GeneIDi819174.
KEGGiath:AT2G45660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003680 Genomic DNA. Translation: AAC06175.1 .
CP002685 Genomic DNA. Translation: AEC10583.1 .
AY007726 mRNA. Translation: AAG16297.1 .
AF385731 mRNA. Translation: AAK60321.1 .
AY093967 mRNA. Translation: AAM16228.1 .
PIRi T00879.
RefSeqi NP_182090.1. NM_130128.3.
UniGenei At.25546.

3D structure databases

ProteinModelPortali O64645.
SMRi O64645. Positions 3-69.
ModBasei Search...

Protein-protein interaction databases

BioGridi 4510. 33 interactions.
IntActi O64645. 35 interactions.
STRINGi 3702.AT2G45660.1-P.

Proteomic databases

PRIDEi O64645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G45660.1 ; AT2G45660.1 ; AT2G45660 .
GeneIDi 819174.
KEGGi ath:AT2G45660.

Organism-specific databases

GeneFarmi 3500. 353.
TAIRi AT2G45660.

Phylogenomic databases

eggNOGi COG5068.
HOGENOMi HOG000155301.
InParanoidi O64645.
OMAi VKCIRAR.
PhylomeDBi O64645.

Gene expression databases

Genevestigatori O64645.

Family and domain databases

InterProi IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view ]
Pfami PF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view ]
PRINTSi PR00404. MADSDOMAIN.
SMARTi SM00432. MADS. 1 hit.
[Graphical view ]
SUPFAMi SSF55455. SSF55455. 1 hit.
PROSITEi PS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A MADS domain gene involved in the transition to flowering in Arabidopsis."
    Borner R., Kampmann G., Chandler J., Gleissner R., Wisman E., Apel K., Melzer S.
    Plant J. 24:591-599(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis."
    Lee H., Suh S.S., Park E., Cho E., Ahn J.H., Kim S.G., Lee J.S., Kwon Y.M., Lee I.
    Genes Dev. 14:2366-2376(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: cv. Landsberg erecta.
  6. Cited for: INTERACTION WITH AGL15; AGL16 AND AGL19.
  7. "Specification of Arabidopsis floral meristem identity by repression of flowering time genes."
    Liu C., Zhou J., Bracha-Drori K., Yalovsky S., Ito T., Yu H.
    Development 134:1901-1910(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY AP1.
  8. "Direct interaction of AGL24 and SOC1 integrates flowering signals in Arabidopsis."
    Liu C., Chen H., Er H.L., Soo H.M., Kumar P.P., Han J.-H., Liou Y.C., Yu H.
    Development 135:1481-1491(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY AGL24.
  9. "FLC or not FLC: the other side of vernalization."
    Alexandre C.M., Hennig L.
    J. Exp. Bot. 59:1127-1135(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "SOC1 translocated to the nucleus by interaction with AGL24 directly regulates leafy."
    Lee J., Oh M., Park H., Lee I.
    Plant J. 55:832-843(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ARG-24; GLU-34 AND GLY-113, INTERACTION WITH AGL24, SUBCELLULAR LOCATION.
  11. "The Arabidopsis floral meristem identity genes AP1, AGL24 and SVP directly repress class B and C floral homeotic genes."
    Gregis V., Sessa A., Dorca-Fornell C., Kater M.M.
    Plant J. 60:626-637(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSOC1_ARATH
AccessioniPrimary (citable) accession number: O64645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi