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Protein

Proteasome subunit beta type-1

Gene

PBF1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit F
20S proteasome subunit beta-6
Gene namesi
Name:PBF1
Ordered Locus Names:Os09g0505600, LOC_Os09g32800
ORF Names:OsJ_29931Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 9

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480391 – 221Proteasome subunit beta type-1Add BLAST221

Proteomic databases

PaxDbiO64464.
PRIDEiO64464.

Expressioni

Gene expression databases

GenevisibleiO64464. OS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os09g32800.1.

Structurei

3D structure databases

ProteinModelPortaliO64464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0179. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091081.
InParanoidiO64464.
KOiK02732.
OMAiQNPLMNG.
OrthoDBiEOG09360LMI.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O64464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRGDWVYE NNGGTCVAIA GADYCVVAAD TRLSVGYNIL TRDHSKICEL
60 70 80 90 100
ADKCALASSG FQGDIKALHK NLAARELLYQ HQHNKRMSCP AMAQLLSNTL
110 120 130 140 150
YYKRFFPYYA FNVLGGLDSE GKGCVFTYDA VGSYERTGYS AQGTGSALIM
160 170 180 190 200
PVLDNQLKSP SPLLLPARDA VTPLSETEAV DLVKDVFASA TERDIYTGDK
210 220
LEIVVINKAG TKREYIDLRK D
Length:221
Mass (Da):24,282
Last modified:August 1, 1998 - v1
Checksum:iF040EE0C2CEA5C64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014058 mRNA. Translation: BAA28276.1.
AC108753 Genomic DNA. No translation available.
AP008215 Genomic DNA. Translation: BAF25517.1.
AP014965 Genomic DNA. Translation: BAT08852.1.
CM000146 Genomic DNA. Translation: EAZ45289.1.
AK060884 mRNA. Translation: BAG87594.1.
AK103136 mRNA. Translation: BAG95912.1.
RefSeqiXP_015611664.1. XM_015756178.1.
UniGeneiOs.3736.

Genome annotation databases

EnsemblPlantsiOS09T0505600-01; OS09T0505600-01; OS09G0505600.
GeneIDi4347507.
GrameneiOS09T0505600-01; OS09T0505600-01; OS09G0505600.
KEGGiosa:4347507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014058 mRNA. Translation: BAA28276.1.
AC108753 Genomic DNA. No translation available.
AP008215 Genomic DNA. Translation: BAF25517.1.
AP014965 Genomic DNA. Translation: BAT08852.1.
CM000146 Genomic DNA. Translation: EAZ45289.1.
AK060884 mRNA. Translation: BAG87594.1.
AK103136 mRNA. Translation: BAG95912.1.
RefSeqiXP_015611664.1. XM_015756178.1.
UniGeneiOs.3736.

3D structure databases

ProteinModelPortaliO64464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os09g32800.1.

Proteomic databases

PaxDbiO64464.
PRIDEiO64464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS09T0505600-01; OS09T0505600-01; OS09G0505600.
GeneIDi4347507.
GrameneiOS09T0505600-01; OS09T0505600-01; OS09G0505600.
KEGGiosa:4347507.

Phylogenomic databases

eggNOGiKOG0179. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091081.
InParanoidiO64464.
KOiK02732.
OMAiQNPLMNG.
OrthoDBiEOG09360LMI.

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

GenevisibleiO64464. OS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB1_ORYSJ
AccessioniPrimary (citable) accession number: O64464
Secondary accession number(s): Q0J0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.