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O64362

- LYS_BPN15

UniProt

O64362 - LYS_BPN15

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Protein
Lysozyme
Gene
54
Organism
Enterobacteria phage N15 (Bacteriophage N15)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton donor By similarity
Active sitei42 – 421Nucleophile By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp54
Gene namesi
Name:54
OrganismiEnterobacteria phage N15 (Bacteriophage N15)
Taxonomic identifieri40631 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeN15likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000002132: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Lysozyme
PRO_0000218097Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO64362.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

O64362-1 [UniParc]FASTAAdd to Basket

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MANRAKLSAA VLSLILAGAS APQILDQFLD EKEGNSLTAY KDGSGIWTIC    50
RGATMVDGKP VMQGMKLTQA KCNQVNAIER NKALAWVDRN IKVPLTEPQK 100
AGIASFCPYN IGPGKCFPST FYKRLNAGDR HGACEAIRWW IKDGGRDCRL 150
TKGQKNGCYG QVERRDQESA LTCWEIDQ 178
Length:178
Mass (Da):19,597
Last modified:August 1, 1998 - v1
Checksum:iD447BEAB4E0B2CDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064539 Genomic DNA. Translation: AAC19069.1.
PIRiT13141.
RefSeqiNP_046950.1. NC_001901.1.

Genome annotation databases

GeneIDi1261692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064539 Genomic DNA. Translation: AAC19069.1 .
PIRi T13141.
RefSeqi NP_046950.1. NC_001901.1.

3D structure databases

ProteinModelPortali O64362.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261692.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence and analysis of the atypical temperate bacteriophage N15."
    Ravin V., Ravin N., Casjens S., Ford M.E., Hatfull G.F., Hendrix R.W.
    J. Mol. Biol. 299:53-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPN15
AccessioniPrimary (citable) accession number: O64362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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