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O64362

- LYS_BPN15

UniProt

O64362 - LYS_BPN15

Protein

Lysozyme

Gene

54

Organism
Enterobacteria phage N15 (Bacteriophage N15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton donorBy similarity
    Active sitei42 – 421NucleophileBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Muramidase
    Protein gp54
    Gene namesi
    Name:54
    OrganismiEnterobacteria phage N15 (Bacteriophage N15)
    Taxonomic identifieri40631 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeN15likevirus
    Virus hostiEscherichia coli [TaxID: 562]
    ProteomesiUP000002132: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178LysozymePRO_0000218097Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO64362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O64362-1 [UniParc]FASTAAdd to Basket

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    MANRAKLSAA VLSLILAGAS APQILDQFLD EKEGNSLTAY KDGSGIWTIC    50
    RGATMVDGKP VMQGMKLTQA KCNQVNAIER NKALAWVDRN IKVPLTEPQK 100
    AGIASFCPYN IGPGKCFPST FYKRLNAGDR HGACEAIRWW IKDGGRDCRL 150
    TKGQKNGCYG QVERRDQESA LTCWEIDQ 178
    Length:178
    Mass (Da):19,597
    Last modified:August 1, 1998 - v1
    Checksum:iD447BEAB4E0B2CDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064539 Genomic DNA. Translation: AAC19069.1.
    PIRiT13141.
    RefSeqiNP_046950.1. NC_001901.1.

    Genome annotation databases

    GeneIDi1261692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064539 Genomic DNA. Translation: AAC19069.1 .
    PIRi T13141.
    RefSeqi NP_046950.1. NC_001901.1.

    3D structure databases

    ProteinModelPortali O64362.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1261692.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence and analysis of the atypical temperate bacteriophage N15."
      Ravin V., Ravin N., Casjens S., Ford M.E., Hatfull G.F., Hendrix R.W.
      J. Mol. Biol. 299:53-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BPN15
    AccessioniPrimary (citable) accession number: O64362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3