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O64362 (LYS_BPN15) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp54
Gene names
Name:54
OrganismEnterobacteria phage N15 (Bacteriophage N15) [Reference proteome]
Taxonomic identifier40631 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeN15likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Lysozyme
PRO_0000218097

Sites

Active site331Proton donor By similarity
Active site421Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
O64362 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D447BEAB4E0B2CDA

FASTA17819,597
        10         20         30         40         50         60 
MANRAKLSAA VLSLILAGAS APQILDQFLD EKEGNSLTAY KDGSGIWTIC RGATMVDGKP 

        70         80         90        100        110        120 
VMQGMKLTQA KCNQVNAIER NKALAWVDRN IKVPLTEPQK AGIASFCPYN IGPGKCFPST 

       130        140        150        160        170 
FYKRLNAGDR HGACEAIRWW IKDGGRDCRL TKGQKNGCYG QVERRDQESA LTCWEIDQ 

« Hide

References

[1]"Genomic sequence and analysis of the atypical temperate bacteriophage N15."
Ravin V., Ravin N., Casjens S., Ford M.E., Hatfull G.F., Hendrix R.W.
J. Mol. Biol. 299:53-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064539 Genomic DNA. Translation: AAC19069.1.
PIRT13141.
RefSeqNP_046950.1. NC_001901.1.

3D structure databases

ProteinModelPortalO64362.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1261692.

Phylogenomic databases

ProtClustDBCLSP2343233.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS_BPN15
AccessionPrimary (citable) accession number: O64362
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries