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Protein

DNA polymerase accessory protein 44

Gene

44

Organism
Enterobacteria phage RB69 (Bacteriophage RB69)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Sliding clamp (Gp45) loader. Required for elongation of primed templates by DNA polymerase. Possesses DNA-dependent ATPase activity on its own and within the heterodimer Gp44/Gp62.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase accessory protein 44
Alternative name(s):
Clamp loader large subunit
Protein Gp44
Gene namesi
Name:44
OrganismiEnterobacteria phage RB69 (Bacteriophage RB69)
Taxonomic identifieri12353 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeRb69virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000876 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649281 – 320DNA polymerase accessory protein 44Add BLAST320

Interactioni

Subunit structurei

Heterodimer of Gp44 and Gp62 that forms a complex with Gp45 in the presence of ATP.

Structurei

3D structure databases

ProteinModelPortaliO64301.
SMRiO64301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To E.coli DNA polymerase III subunits gamma/tau and to human activator 1, 37 and 40 kDa subunits.Curated

Phylogenomic databases

KOiK18944.
OrthoDBiVOG090000G0.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O64301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITINSKEHI LEQKYRPSSI DECILPAYDH ETFKSLVSKG KLPHIILHSP
60 70 80 90 100
SPGTGKTTVA KALCNDINAE MMFVNGSDCK IDFVRGPLTA FARSVSMEGK
110 120 130 140 150
PKVIVIDEFD RSGLAESQRH LRTFMEEFSS NCSIIITANN IDGIIEPLRS
160 170 180 190 200
RCRVIEFGRP TEEDKISMMK KMIHRMVEIC KNENIEIADM KVVAALVKKN
210 220 230 240 250
FPDFRRTIGQ LDQYSSKGVL DAGILSIVTN DRGTVSDVIE AMKNKDIKQL
260 270 280 290 300
RALAPKYAAD YSWFIDKLVS ECYDQVAPGK SIISLYEIAG ENNKFHGLAS
310 320
NIELHVMYML LQLTCELTWK
Length:320
Mass (Da):36,043
Last modified:August 1, 1998 - v1
Checksum:i3EB83BE9C4BDB609
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039565 Genomic DNA. Translation: AAC39311.1.
AY303349 Genomic DNA. Translation: AAP75961.1.
RefSeqiNP_861749.1. NC_004928.1.

Genome annotation databases

GeneIDi1494175.
KEGGivg:1494175.

Similar proteinsi

Entry informationi

Entry nameiDPA44_BPR69
AccessioniPrimary (citable) accession number: O64301
Secondary accession number(s): Q76XX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 12, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome