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O64240

- VG50_BPMD2

UniProt

O64240 - VG50_BPMD2

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Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage D29 (Mycobacteriophage D29)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei375 – 3751By similarity
Active sitei377 – 3771By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Alternative name(s):
Gp50
Gene namesi
Name:50
OrganismiMycobacterium phage D29 (Mycobacteriophage D29)
Taxonomic identifieri28369 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000002131: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 386Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO64240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

O64240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEGEIPWGP TGELVYNRTY SRVKPDGTRE TWPETVERVV SGNLALVDSR
60 70 80 90 100
YQLPGEREDL LRLMREFKIL PAGRHLWASG VKNAQHLFNC WVSGWTEKPS
110 120 130 140 150
DHFEFTFMRL MEGGGVGANY SNRFLADYPH VKQELEVHIV CDEDHDDYAD
160 170 180 190 200
LAEAGQLSSR YDSDWVDAFV IEDSREGWAA ALVDLIDTHY RDDVAHKERV
210 220 230 240 250
YDVSRVRAAG RKLKTFGGTA SGPVPLAKML TEVSEILSRC AREGEQYRFE
260 270 280 290 300
DGGALTGLDA MEIDHAIAQC VVAGGVRRSA RMAMMHWADW QVETFTNIKQ
310 320 330 340 350
DSGSHWTTNI SVEVDDAFWS LAKAPVDPLN PRSTKAHRVL KALSEGAVRN
360 370 380 390 400
GEPGMWDSSL SNVGEPNEVV CTNPCGEITL EPWEPCNLGH INLAAFVTDA
410 420 430 440 450
GKTDYIDLIR AHRLMTRFLI RATFSAVADP KSREVLDRNR RIGVGHLGVA
460 470 480 490 500
SYLALTGRRY SQAPGDKRFT AFLREMAAEV DRAAEEFSHE LRIPVPVKKR
510 520 530 540 550
TVAPTGTIAK MPGVSEGIHP IFSRYFIRRI RFSVLDNDQF LTASQYAADG
560 570 580 590 600
YHVEKDQYDK SGNTWVVEIP TKDTLVEAVA ARFGRDAEDI VESANELTLH
610 620 630 640 650
QLLAFQALYQ TCWADNAVSF TANVDPDAYE GVDVAADLQR FSGLIKGSTI
660 670 680 690
FPEESFPQAP YERITKQQYE AAAIKAVADG VDEECANGAC PIK
Length:693
Mass (Da):77,250
Last modified:August 1, 1998 - v1
Checksum:i148B752C15EC561F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022214 Genomic DNA. Translation: AAC18490.1.
PIRiG72805.
RefSeqiNP_046865.1. NC_001900.1.

Genome annotation databases

GeneIDi1261592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022214 Genomic DNA. Translation: AAC18490.1 .
PIRi G72805.
RefSeqi NP_046865.1. NC_001900.1.

3D structure databases

ProteinModelPortali O64240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261592.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome structure of mycobacteriophage D29: implications for phage evolution."
    Ford M.E., Sarkis G.J., Belanger A.E., Hendrix R.W., Hatfull G.F.
    J. Mol. Biol. 279:143-164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiVG50_BPMD2
AccessioniPrimary (citable) accession number: O64240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3