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O64240

- VG50_BPMD2

UniProt

O64240 - VG50_BPMD2

Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage D29 (Mycobacteriophage D29)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei375 – 3751By similarity
    Active sitei377 – 3771By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Alternative name(s):
    Gp50
    Gene namesi
    Name:50
    OrganismiMycobacterium phage D29 (Mycobacteriophage D29)
    Taxonomic identifieri28369 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
    Virus hostiMycobacterium [TaxID: 1763]
    ProteomesiUP000002131: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 386Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliO64240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O64240-1 [UniParc]FASTAAdd to Basket

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    MTEGEIPWGP TGELVYNRTY SRVKPDGTRE TWPETVERVV SGNLALVDSR    50
    YQLPGEREDL LRLMREFKIL PAGRHLWASG VKNAQHLFNC WVSGWTEKPS 100
    DHFEFTFMRL MEGGGVGANY SNRFLADYPH VKQELEVHIV CDEDHDDYAD 150
    LAEAGQLSSR YDSDWVDAFV IEDSREGWAA ALVDLIDTHY RDDVAHKERV 200
    YDVSRVRAAG RKLKTFGGTA SGPVPLAKML TEVSEILSRC AREGEQYRFE 250
    DGGALTGLDA MEIDHAIAQC VVAGGVRRSA RMAMMHWADW QVETFTNIKQ 300
    DSGSHWTTNI SVEVDDAFWS LAKAPVDPLN PRSTKAHRVL KALSEGAVRN 350
    GEPGMWDSSL SNVGEPNEVV CTNPCGEITL EPWEPCNLGH INLAAFVTDA 400
    GKTDYIDLIR AHRLMTRFLI RATFSAVADP KSREVLDRNR RIGVGHLGVA 450
    SYLALTGRRY SQAPGDKRFT AFLREMAAEV DRAAEEFSHE LRIPVPVKKR 500
    TVAPTGTIAK MPGVSEGIHP IFSRYFIRRI RFSVLDNDQF LTASQYAADG 550
    YHVEKDQYDK SGNTWVVEIP TKDTLVEAVA ARFGRDAEDI VESANELTLH 600
    QLLAFQALYQ TCWADNAVSF TANVDPDAYE GVDVAADLQR FSGLIKGSTI 650
    FPEESFPQAP YERITKQQYE AAAIKAVADG VDEECANGAC PIK 693
    Length:693
    Mass (Da):77,250
    Last modified:August 1, 1998 - v1
    Checksum:i148B752C15EC561F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022214 Genomic DNA. Translation: AAC18490.1.
    PIRiG72805.
    RefSeqiNP_046865.1. NC_001900.1.

    Genome annotation databases

    GeneIDi1261592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022214 Genomic DNA. Translation: AAC18490.1 .
    PIRi G72805.
    RefSeqi NP_046865.1. NC_001900.1.

    3D structure databases

    ProteinModelPortali O64240.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1261592.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of mycobacteriophage D29: implications for phage evolution."
      Ford M.E., Sarkis G.J., Belanger A.E., Hendrix R.W., Hatfull G.F.
      J. Mol. Biol. 279:143-164(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiVG50_BPMD2
    AccessioniPrimary (citable) accession number: O64240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3