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Protein

Protein AimP

Gene

aimP

Organism
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Protein AimP: Part of the latency-replication switch system which decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable.By similarity
Arbitrium peptide: Peptide which is released by the infected host bacteria and acts as a communication agent that affects the latency versus replication (lysogeny-lysis) decision for any new infecting virus from the same specie. High concentration of arbitrium peptide results in increased lysogeny in the upcoming viruses. The arbitrium peptide is secreted by infected bacteria and, after several cycles of infection, accumulates in the extracellular medium. When a virus from the same specie subsequently infects an uninfected bacterium which has internalized the peptide via its OPP transporter, the peptide will binds to the viral AimR transcriptional regulator and prevents AimR transcriptional activation of the aimX locus. Inhibition of aimX transcription promotes lysogeny.By similarity

Keywordsi

Biological processLatency-replication decision, Viral latency

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AimPBy similarity
Alternative name(s):
YopL protein
Cleaved into the following chain:
Arbitrium peptideBy similarity
Gene namesi
Name:aimPBy similarity
Synonyms:yopL
OrganismiBacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Taxonomic identifieri66797 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeSpbetavirus
Virus hostiBacillus pumilus (Bacillus mesentericus) [TaxID: 1408]
Bacillus subtilis [TaxID: 1423]
Proteomesi
  • UP000009091 Componenti: Genome

Subcellular locationi

Peptide Arbitrium peptide :
  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000043925422 – 41Protein AimPSequence analysisAdd BLAST20
PeptideiPRO_000043925536 – 41Arbitrium peptideSequence analysis6

Post-translational modificationi

Protein AimP: Cleaved by host extracellular proteases, thereby releasing the mature arbitrium peptide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei35 – 36Cleavage; by hostBy similarity2

Interactioni

Subunit structurei

Arbitrium peptide: Interacts with the viral AimR transcriptional regulator; this interaction changes the oligomeric state of AimR from an active dimer to an inactive monomer leading to lysogeny.By similarity

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O64095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MKKLIMALVI LGALGTSYIS ADSSIQQASG DYEVAGMPRG A
Length:41
Mass (Da):4,215
Last modified:August 1, 1998 - v1
Checksum:i3A9A6DCC528F9A60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020713 Genomic DNA. Translation: AAC13055.1.
PIRiT12846.
RefSeqiNP_046634.1. NC_001884.1.

Genome annotation databases

GeneIDi1261412.
KEGGivg:1261412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020713 Genomic DNA. Translation: AAC13055.1.
PIRiT12846.
RefSeqiNP_046634.1. NC_001884.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261412.
KEGGivg:1261412.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiAIMP_BPSPB
AccessioniPrimary (citable) accession number: O64095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: August 1, 1998
Last modified: April 12, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.