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O63915

- COX3_MYXGL

UniProt

O63915 - COX3_MYXGL

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Protein

Cytochrome c oxidase subunit 3

Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Myxine glutinosa (Atlantic hagfish)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiMyxine glutinosa (Atlantic hagfish)
Taxonomic identifieri7769 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeMyxininaeMyxine

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei159 – 17921Helical; Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183811Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO63915.
SMRiO63915. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016686.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O63915-1 [UniParc]FASTAAdd to Basket

« Hide

MTKQMHAFHM VNPSPWPLTG AASAFMLTSG LAMWFHKHSN TLIFLSMILM    50
LLTMYQWWRD ITREGTFQGH HTSLVQKSLR YGMILFIVSE VCFFFGFFWT 100
FYHSSLSPSP DLGMMWPPKG VIPLDPFEIP LLNTAILLGS GVSVTWAHHS 150
LMEKTHKDMV ISLSITIILG IYFTLLQGME YFNSTFNISD NAYGSTFFVA 200
TGFHGGHVII GTLFLTVCLL RQLMFHFTSS HHFGFEAAAW YWHFVDVVWL 250
FLFISIYWWG S 261
Length:261
Mass (Da):30,052
Last modified:August 1, 1998 - v1
Checksum:i97A9448357E6BD82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15184 Genomic DNA. Translation: CAA75483.1.
AJ404477 Genomic DNA. Translation: CAC20655.1.
RefSeqiNP_073279.1. NC_002639.1.

Genome annotation databases

GeneIDi802345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15184 Genomic DNA. Translation: CAA75483.1 .
AJ404477 Genomic DNA. Translation: CAC20655.1 .
RefSeqi NP_073279.1. NC_002639.1.

3D structure databases

ProteinModelPortali O63915.
SMRi O63915. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802345.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

HOVERGENi HBG016686.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and vertebrate phylogeny."
    Rasmussen A.S., Janke A., Arnason U.
    J. Mol. Evol. 46:382-388(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique features of the control region."
    Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.
    J. Mol. Evol. 53:634-641(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_MYXGL
AccessioniPrimary (citable) accession number: O63915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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