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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Glis glis (Fat dormouse) (Myoxus glis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiGlis glis (Fat dormouse) (Myoxus glis)
Taxonomic identifieri41261 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiGliridaeGlirinaeGlis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei325 – 347HelicalSequence analysisAdd BLAST23
Transmembranei360 – 382HelicalSequence analysisAdd BLAST23
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001181151 – 603NADH-ubiquinone oxidoreductase chain 5Add BLAST603

Proteomic databases

PRIDEiO63908.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

O63908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFSSFTLM TFSILLYPIL LSFTDQYNNN LFPNHVKTSI ICAFLFSLIP
60 70 80 90 100
TLMFINSGYD MIISNWHWMT IQTLNLTMSF KMDMFSMMFV PVALFVTWSI
110 120 130 140 150
MEFSLWYMHS DPYINRFFKY LLLFLITMII LVTANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RPDANTAALQ AVLYNRIGDI GFVLSMAWFL MHSSSWEFQQ
210 220 230 240 250
RFSSQNSSNI LPLLGLILAA AGKSAQFGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGVFLL IRFYPFIKNN QLVQSIIMCL GAITTLFTAI CALTQNDIKK
310 320 330 340 350
IIAFSTSSQL GLMMVTIGIN QPYLAFFHIC THAFFKAMLF MCSGSIIHNL
360 370 380 390 400
NDEQDIRKMG GLFKTLPFTS SELTVGSLTL TGTPYLTGFY SKDLIIESAN
410 420 430 440 450
TSYTNAWALS ITLIATSLTA IYSTRIIFLL IRSKPRFVPL SPINENNPLL
460 470 480 490 500
NNAIKRLLIG SIFAGFLITN NMTPMSIQQM TMPWYLKLTA LIVTILGFMM
510 520 530 540 550
AMELNNLSLY FKYKTTSQHV KFSNLLGFFP STMHRLFPNT NLLISHNSAS
560 570 580 590 600
TLLDLIWLEK STPKLLSSTQ LMDSTLSSNQ TGLIKLYFLS FLLSMLMVTM

LII
Length:603
Mass (Da):68,238
Last modified:August 1, 1998 - v1
Checksum:i9AC8D41FCFB9E575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001562 Genomic DNA. Translation: CAA04840.1.
PIRiT11399.
RefSeqiNP_007520.1. NC_001892.1.

Genome annotation databases

GeneIDi808180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001562 Genomic DNA. Translation: CAA04840.1.
PIRiT11399.
RefSeqiNP_007520.1. NC_001892.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO63908.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808180.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_GLIGL
AccessioniPrimary (citable) accession number: O63908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.