Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Bodo saltans (Flagellated protozoan)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COX1Imported
Encoded oniMitochondrionImported
OrganismiBodo saltans (Flagellated protozoan)Imported
Taxonomic identifieri75058 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaBodonidaeBodo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalSequence analysisAdd BLAST19
Transmembranei59 – 85HelicalSequence analysisAdd BLAST27
Transmembranei105 – 132HelicalSequence analysisAdd BLAST28
Transmembranei144 – 162HelicalSequence analysisAdd BLAST19
Transmembranei182 – 214HelicalSequence analysisAdd BLAST33
Transmembranei247 – 266HelicalSequence analysisAdd BLAST20
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei305 – 323HelicalSequence analysisAdd BLAST19
Transmembranei335 – 361HelicalSequence analysisAdd BLAST27
Transmembranei381 – 400HelicalSequence analysisAdd BLAST20
Transmembranei407 – 431HelicalSequence analysisAdd BLAST25
Transmembranei451 – 477HelicalSequence analysisAdd BLAST27
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Transmembranei524 – 547HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO63543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 508COX1InterPro annotationAdd BLAST508

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O63543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFLSLLCLT VSHKMIGLSY LILAIMCGFV GYVYSLFIRL ELSLLGCGVL
60 70 80 90 100
FGDYQFYNVI ITSHGLIMIF AFIMPVMTGG FTNYYAPVMV GFPDMVFPRL
110 120 130 140 150
NNMSFWLFFL GFACVVSSIV TEEGVGTGWT LYPTLICIDF HSSLACDFMI
160 170 180 190 200
FAVHSLGVSS ILNSLNVVGT FFCCRRKYYS FLFWLLFVWG VLLTSILLIL
210 220 230 240 250
TLPVLAGAVT MLLVDRNFNT SFYDVVGGGD LVMFQHLFWF FGHPEVYIII
260 270 280 290 300
LPVFGLVSTL IDIIGLRCVF STVAMIYSML LICLLGFFVW AHHMFVVGLD
310 320 330 340 350
LDTRAYFGSI TLLIGLPTCI KLFNWFYSFL FVDMILVFEI YFVYTFIFMF
360 370 380 390 400
LFGGVTGLLL ANVGVDILLH DTYFVVAHFH YVLSLGAVIG FFGGFLHFCV
410 420 430 440 450
RWLPIEFYLF WMYYFLWTLW LGSNLLFLPI HSLGLYAFPR RISDYPISFL
460 470 480 490 500
FWSYVLLCGM LFLVCLVLFA ACLFSVLMFW DYCIFFVSIF IYCLFCFYSF
510 520 530 540
NSWLPFVMAL YLLLVDFAHI VLDYLFIIIS FCFIYYLFFF SNFVLLLL
Length:548
Mass (Da):63,324
Last modified:August 1, 1998 - v1
Checksum:i95AB726668B0CE2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041263 Genomic DNA. Translation: AAC38978.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041263 Genomic DNA. Translation: AAC38978.1.

3D structure databases

ProteinModelPortaliO63543.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO63543_BODSA
AccessioniPrimary (citable) accession number: O63543
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.